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Q2L1L0

- PCKG_BORA1

UniProt

Q2L1L0 - PCKG_BORA1

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Protein
Phosphoenolpyruvate carboxykinase [GTP]
Gene
pckG, BAV1626
Organism
Bordetella avium (strain 197N)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle By similarity.UniRule annotation

Catalytic activityi

GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2.UniRule annotation

Cofactori

Binds 1 manganese ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei85 – 851Substrate By similarity
Binding sitei226 – 2261Substrate; via amide nitrogen By similarity
Metal bindingi233 – 2331Manganese By similarity
Binding sitei233 – 2331Substrate By similarity
Metal bindingi253 – 2531Manganese; via tele nitrogen By similarity
Binding sitei275 – 2751Substrate By similarity
Active sitei277 – 2771 By similarity
Metal bindingi302 – 3021Manganese By similarity
Binding sitei398 – 3981GTP By similarity
Binding sitei429 – 4291GTP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi276 – 2816GTP By similarity
Nucleotide bindingi526 – 5294GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-HAMAP
  2. manganese ion binding Source: UniProtKB-HAMAP
  3. phosphoenolpyruvate carboxykinase (GTP) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Gluconeogenesis

Keywords - Ligandi

GTP-binding, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBAVI360910:GCKI-1652-MONOMER.
UniPathwayiUPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxykinase [GTP] (EC:4.1.1.32)
Short name:
PEP carboxykinase
Short name:
PEPCK
Gene namesi
Name:pckG
Ordered Locus Names:BAV1626
OrganismiBordetella avium (strain 197N)
Taxonomic identifieri360910 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
ProteomesiUP000001977: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 621621Phosphoenolpyruvate carboxykinase [GTP]UniRule annotation
PRO_1000060287Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi360910.BAV1626.

Structurei

3D structure databases

ProteinModelPortaliQ2L1L0.
SMRiQ2L1L0. Positions 17-617.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni396 – 3983Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1274.
HOGENOMiHOG000191700.
KOiK01596.
OMAiWDNPAGV.
OrthoDBiEOG6MPWQS.

Family and domain databases

Gene3Di3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPiMF_00452. PEPCK_GTP.
InterProiIPR018091. PEP_carboxykin_GTP_CS.
IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view]
PANTHERiPTHR11561. PTHR11561. 1 hit.
PfamiPF00821. PEPCK. 1 hit.
[Graphical view]
PIRSFiPIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMiSSF68923. SSF68923. 1 hit.
PROSITEiPS00505. PEPCK_GTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2L1L0-1 [UniParc]FASTAAdd to Basket

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MTQAAEATLP PLNVPSYVKH ARLIDWVQGV VALTKPARVV WCDGSQEEAD    50
RLCEQMVQAG TMRRLNPAKR PNSYLAWSDP SDVARVEDRT FICSQREEDA 100
GPTNNWAAPA EMRNTLQGLF DGAMRGRTLY VVPFSMGPLG SPIAHIGVEL 150
SDSPYVAVNM RIMTRMGRAV WDVLGADGEF VPCVHSVGMP LAEGQADVAW 200
PCNPVKYIVH YPETREIWSF GSGYGGNALL GKKCFALRIA STMGRDEGWL 250
AEHMLILGVT TPKGRKFHVA AAFPSACGKT NFAMLIPPSG MDGWKVSTIG 300
DDIAWIKPGQ DGRLRAINPE AGYFGVAPGT SEKTNPNAMA TLKANVIFTN 350
VALTDDGDVW WEGMTDTPPA HLIDWQGKDW TPEIARETGR KAAHPNARFT 400
APASQCPSID PEWENPQGVA IDAFIFGGRR STTIPLVTEA RDWVQGVYMA 450
ATMGSETTAA AVGQQGVVRR DPFAMLPFCG YNMADYFNHW LAVGQRLADA 500
GATLPRIYCV NWFRKGPNGK FVWPGFGENM RVLKWMLGRL SGEAGGQEQV 550
FGISPSYGDV DWTGLEFTPD QFQQVISVEA PAWREELALH GELFEQLAQG 600
LPPALSRAKA DIEHRLAAVQ A 621
Length:621
Mass (Da):67,910
Last modified:March 7, 2006 - v1
Checksum:i70C191E3B587F43F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM167904 Genomic DNA. Translation: CAJ49235.1.
RefSeqiYP_786146.1. NC_010645.1.

Genome annotation databases

GeneIDi6265530.
KEGGibav:BAV1626.
PATRICi21129428. VBIBorAvi43433_1636.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM167904 Genomic DNA. Translation: CAJ49235.1 .
RefSeqi YP_786146.1. NC_010645.1.

3D structure databases

ProteinModelPortali Q2L1L0.
SMRi Q2L1L0. Positions 17-617.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360910.BAV1626.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 6265530.
KEGGi bav:BAV1626.
PATRICi 21129428. VBIBorAvi43433_1636.

Phylogenomic databases

eggNOGi COG1274.
HOGENOMi HOG000191700.
KOi K01596.
OMAi WDNPAGV.
OrthoDBi EOG6MPWQS.

Enzyme and pathway databases

UniPathwayi UPA00138 .
BioCyci BAVI360910:GCKI-1652-MONOMER.

Family and domain databases

Gene3Di 3.40.449.10. 1 hit.
3.90.228.20. 2 hits.
HAMAPi MF_00452. PEPCK_GTP.
InterProi IPR018091. PEP_carboxykin_GTP_CS.
IPR013035. PEP_carboxykinase_C.
IPR008209. PEP_carboxykinase_GTP.
IPR008210. PEP_carboxykinase_N.
[Graphical view ]
PANTHERi PTHR11561. PTHR11561. 1 hit.
Pfami PF00821. PEPCK. 1 hit.
[Graphical view ]
PIRSFi PIRSF001348. PEP_carboxykinase_GTP. 1 hit.
SUPFAMi SSF68923. SSF68923. 1 hit.
PROSITEi PS00505. PEPCK_GTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparison of the genome sequence of the poultry pathogen Bordetella avium with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals extensive diversity in surface structures associated with host interaction."
    Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D., King N.D., Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D., Goble A., Lord A., Murphy L., Quail M.A., Rutter S., Squares R., Squares S., Woodward J., Parkhill J., Temple L.M.
    J. Bacteriol. 188:6002-6015(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 197N.

Entry informationi

Entry nameiPCKG_BORA1
AccessioniPrimary (citable) accession number: Q2L1L0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 7, 2006
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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