Reviewed, UniProtKB/Swiss-Prot Q2L1K6 (SYD_BORA1)

Names and origin

Protein names

Recommended name:
    Aspartyl-tRNA synthetase
    EC=6.1.1.12
Alternative name(s):
    Aspartate--tRNA ligase
      Short name=AspRS

Gene names

Name:	aspS
Ordered Locus Names:	BAV0115

Organism

Bordetella avium (strain 197N) [Complete proteome] [HAMAP]

Taxonomic identifier

360910 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	596 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp). HAMAP MF_00044
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm. HAMAP MF_00044
Sequence similarities	Belongs to the class-II aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aspartyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP aspartate-tRNA ligase activity Inferred from electronic annotation. Source: HAMAP nucleic acid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 596	596	Aspartyl-tRNA synthetase HAMAP MF_00044		PRO_0000235510

Sequences

	Sequence		Length	Mass (Da)
	Q2L1K6-1 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 62CD2B48A18794CB	FASTA	596	67,155
	10 20 30 40 50 60 MRTCYTGQVC RDHLGQTVTL YGWVNRRRDH GGVIFIDLRD RTGLAQIVFD PDNAGAFGTA 70 80 90 100 110 120 ERLRNEFCVR VTGLVRERPQ GTTNAELASG EVEVLCRDVE ILNPSVTPPF QLDDDNLSET 130 140 150 160 170 180 TRLTHRVLDL RRPQMQRNLM LRYRVSIEVR KFLDQLGFID IETPMLTKST PEGARDYLVP 190 200 210 220 230 240 SRVNAGHFFA LPQSPQLFKQ MLMVSGFDRY YQITKCFRDE DLRADRQPEF TQIDCETSFL 250 260 270 280 290 300 TETEIRAVFE SMIRHVFKVV QNVDLPDPFP IMTWTEAMAR FGSDKPDMRV NLEFTDVADI 310 320 330 340 350 360 MRDVDFKVFA SAATTQGSRV VALRVPGGGE LSRSEIDAYT QFVGIYGAKG LAYIKVNDVA 370 380 390 400 410 420 KGREGLQSPI VKNLHDAALA ELVKRTGAQD GDIIFFGADR AKVVNDALGA LRVKIGHSEF 430 440 450 460 470 480 GKKTGLFSGG WRPLWVVDFP MFEYDEEEGR YTAAHHPFTS PKDGHEDFLE TDPSQAFAKA 490 500 510 520 530 540 YDMVLNGWEI GGGSVRIHRE EVQSKVFRAL KIGPDEAREK FGFLLDALQY GAPPHGGIAF 550 560 570 580 590 GLDRIVTMMT GADSIRDVIA FPKTQRAQDL LTQAPSSVDD KQLRELHIRL RNTEVK

References

[1]

"Comparison of the genome sequence of the poultry pathogen Bordetella avium with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals extensive diversity in surface structures associated with host interaction." Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D., King N.D., Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D., Goble A., Lord A., Murphy L., Quail M.A., Rutter S., Squares R., Squares S., Woodward J., Parkhill J., Temple L.M. J. Bacteriol. 188:6002-6015(2006) [PubMed: 16885469] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM167904 Genomic DNA. Translation: CAJ47721.1.
RefSeq	YP_784653.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6264502.
GenomeReviews	Gene locus BAV0115 in contig AM167904_GR.
KEGG	bav:BAV0115.
NMPDR	fig|521.1.peg.1263.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2L1K6.
OMA	Q2L1K6. VDRRRDH.
Family and domain databases
HAMAP	MF_00044. [Tree]
InterPro	IPR004364. aa-tRNA-synt_II. IPR018150. aa-tRNA-synt_II-like. IPR006195. aa-tRNA-synth_II_cons-reg. IPR002312. Asp-tRNA-synth_IIb. IPR004524. Asp-tRNA-synth_IIb_bac/mt. IPR018153. Asp-tRNA-synth_IIb_C_bac/mt. IPR004115. GAD. IPR012340. NA-bd_OB-fold. IPR004365. NA_bd_OB_tRNA-helicase. [Graphical view]
Gene3D	G3DSA:2.40.50.140. OB_NA_bd_sub. 1 hit.
PANTHER	PTHR22594. aa-tRNA-synt_II. 1 hit. PTHR22594:SF5. AspS_bac. 1 hit.
Pfam	PF02938. GAD. 1 hit. PF00152. tRNA-synt_2. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
PRINTS	PR01042. TRNASYNTHASP.
TIGRFAMs	TIGR00459. aspS_bact. 1 hit.
PROSITE	PS50862. AA_TRNA_LIGASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYD_BORA1

Accession

Primary (citable) accession number: Q2L1K6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	March 7, 2006
Last modified:	June 16, 2009
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)