Q2L1J6 (ARLY_BORA1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1

Alternative name(s):
Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	BAV1635

Organism

Bordetella avium (strain 197N) [Complete proteome] [HAMAP]

Taxonomic identifier

360910 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	470 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm By similarity HAMAP MF_00006.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 470	470	Argininosuccinate lyase HAMAP MF_00006		PRO_0000240715

Sequences

	Sequence		Length	Mass (Da)
	Q2L1J6 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 5DC0E12724EB3626	FASTA	470	51,763
	10 20 30 40 50 60 MANTPSQQDQ FANKAQAWSA RFSEPVSDLV KRYTASVDFD KRLARHDIRG SLAHADMLAA 70 80 90 100 110 120 QGIISAQDLA DIERGMQQIL SEIDAGSFQW LLDLEDVHLN IEKRLVELVG DAGKRLHTGR 130 140 150 160 170 180 SRNDQVATDI RLWLRDEIDL LIDLLRQLRH ALATVALDNA GTIMPGFTHL QVAQPVTFGH 190 200 210 220 230 240 HLLAYAEMFG RDAERLADCR KRVNRLPLGA AALAGTSYPI DRERVASTLG FDGVCRNSLD 250 260 270 280 290 300 AVSDRDFAIE FCAAASLIMT HVSRLSEELV LWMSPRVGFI DLADRFCTGS SIMPQKKNPD 310 320 330 340 350 360 VPELARGKTG RVNGHLVALL TLMKGQPLAY NKDNQEDKEG LFDTADTLRD TLTIFADMAG 370 380 390 400 410 420 GIKVKADNMR AAALQGFATA TDLADYLVKR GLPFRDAHEV VAHAVRDCEQ RGCDLADLSL 430 440 450 460 470 AELQAYHPSI EADIHQVLTL EGSVAARKHT GGTAPERVRE EAQRVIQETA

References

[1]

"Comparison of the genome sequence of the poultry pathogen Bordetella avium with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals extensive diversity in surface structures associated with host interaction." Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D., King N.D., Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D., Goble A., Lord A., Murphy L., Quail M.A., Rutter S., Squares R., Squares S., Woodward J., Parkhill J., Temple L.M. J. Bacteriol. 188:6002-6015(2006) [PubMed: 16885469] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 197N.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM167904 Genomic DNA. Translation: CAJ49244.1.
RefSeq	YP_786155.1. NC_010645.1.
3D structure databases
ProteinModelPortal	Q2L1J6.
SMR	Q2L1J6. Positions 28-465.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2L1J6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6265535.
GenomeReviews	Gene locus BAV1635 in contig AM167904_GR.
KEGG	bav:BAV1635.
NMPDR	fig|521.1.peg.1773.
PATRIC	21129450. VBIBorAvi43433_1646.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG539632.
OMA	MAEDLIF.
ProtClustDB	PRK00855.
Enzyme and pathway databases
BioCyc	ABAU360910:BAV1635-MONOMER.
Family and domain databases
HAMAP	MF_00006. Arg_succ_lyase. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. IPR008948. L-Aspartase-like. IPR022761. Lyase1_N. [Graphical view]
KO	K01755.
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
SUPFAM	SSF48557. L-Aspartase-like. 1 hit.
TIGRFAMs	TIGR00838. ArgH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_BORA1

Accession

Primary (citable) accession number: Q2L1J6

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	March 7, 2006
Last modified:	January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program