Q2L1H6 (UBIC_BORA1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable chorismate--pyruvate lyase
Short name=CL
Short name=CPL
EC=4.1.3.40

Gene names

Name:	ubiC
Ordered Locus Names:	BAV1650

Organism

Bordetella avium (strain 197N) [Complete proteome] [HAMAP]

Taxonomic identifier

360910 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	198 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway By similarity. HAMAP MF_01632
Catalytic activity	Chorismate = 4-hydroxybenzoate + pyruvate. HAMAP MF_01632
Pathway	Cofactor biosynthesis; ubiquinone biosynthesis. HAMAP MF_01632
Subcellular location	Cytoplasm By similarity HAMAP MF_01632.
Sequence similarities	Belongs to the ubiC family.

Ontologies

Keywords
Biological process	Ubiquinone biosynthesis
Cellular component	Cytoplasm
Ligand	Pyruvate
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ubiquinone biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	chorismate lyase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 198	198	Probable chorismate--pyruvate lyase HAMAP MF_01632		PRO_0000240536
Sites
	Binding site	76	1	Substrate By similarity
	Binding site	114	1	Substrate; via amide nitrogen By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2L1H6 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 5FF2943BEB5D1272	FASTA	198	22,167
	10 20 30 40 50 60 MTTKYQAPLA AGWLIRAPSL LSPTQRHWLF RPGALTAGLR QLGKVQLRVV SEHAEGASLD 70 80 90 100 110 120 EARAMLIAPG SPVWVREVLM SVDGIDSVPA RSLTPLAASH GSWQGMRRLL TRPLADMLYH 130 140 150 160 170 180 DRGVTRSPFV CRRLSSPLPF YRMALPPNHD GSAIWARRSV FWRHGQPLLV AECFLPDFWR 190 KVTLGRAIPP LKAHDRRA

References

[1]

"Comparison of the genome sequence of the poultry pathogen Bordetella avium with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals extensive diversity in surface structures associated with host interaction." Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D., King N.D., Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D., Goble A., Lord A., Murphy L., Quail M.A., Rutter S., Squares R., Squares S., Woodward J., Parkhill J., Temple L.M. J. Bacteriol. 188:6002-6015(2006) [PubMed: 16885469] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 197N.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM167904 Genomic DNA. Translation: CAJ49258.1.
RefSeq	YP_786168.1. NC_010645.1.
3D structure databases
ProteinModelPortal	Q2L1H6.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2L1H6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6265545.
GenomeReviews	Gene locus BAV1650 in contig AM167904_GR.
KEGG	bav:BAV1650.
NMPDR	fig|521.1.peg.1761.
PATRIC	21129480. VBIBorAvi43433_1661.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG644467.
OMA	SAIWARR.
ProtClustDB	CLSK2305639.
Enzyme and pathway databases
BioCyc	ABAU360910:BAV1650-MONOMER.
Family and domain databases
HAMAP	MF_01632. UbiC. [Tree]
InterPro	IPR007440. Chorismate--pyruvate_lyase. [Graphical view]
KO	K03181.
Pfam	PF04345. Chor_lyase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UBIC_BORA1

Accession

Primary (citable) accession number: Q2L1H6

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	March 7, 2006
Last modified:	January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program