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Protein

Type III pantothenate kinase

Gene

coaX

Organism
Bordetella avium (strain 197N)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.UniRule annotation

Catalytic activityi

ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate.UniRule annotation

Cofactori

NH4(+)UniRule annotation, K+UniRule annotationNote: A monovalent cation. Ammonium or potassium.UniRule annotation

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Type III pantothenate kinase (coaX)
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei92SubstrateUniRule annotation1
Active sitei101Proton acceptorUniRule annotation1
Binding sitei127ATPUniRule annotation1
Binding sitei177SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi6 – 13ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Coenzyme A biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding, Potassium

Enzyme and pathway databases

BioCyciBAVI360910:GCKI-132-MONOMER.
UniPathwayiUPA00241; UER00352.

Names & Taxonomyi

Protein namesi
Recommended name:
Type III pantothenate kinaseUniRule annotation (EC:2.7.1.33UniRule annotation)
Alternative name(s):
PanK-IIIUniRule annotation
Pantothenic acid kinaseUniRule annotation
Gene namesi
Name:coaXUniRule annotation
Ordered Locus Names:BAV0128
OrganismiBordetella avium (strain 197N)
Taxonomic identifieri360910 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
Proteomesi
  • UP000001977 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002708641 – 259Type III pantothenate kinaseAdd BLAST259

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi360910.BAV0128.

Structurei

3D structure databases

ProteinModelPortaliQ2L1G9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni99 – 102Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the type III pantothenate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108194. Bacteria.
COG1521. LUCA.
HOGENOMiHOG000066026.
KOiK03525.
OMAiPWQHAGA.

Family and domain databases

HAMAPiMF_01274. Pantothen_kinase_3. 1 hit.
InterProiIPR004619. Type_III_PanK.
[Graphical view]
PfamiPF03309. Pan_kinase. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2L1G9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLLIDSGNS RLKLGWLRSG AREPEPAAFD NLDLQALASW LQTLRPRPTR
60 70 80 90 100
AIGVNVAGQA RGEAIAAILA QCGCSIEWMR PRREVLGMTN AYRNQAQLGA
110 120 130 140 150
DRWAAMLGLR MRLPEGHPPA LLASFGTATT LDTLGPDNEF AGGLILPGPT
160 170 180 190 200
MMRGALVHGT ANLPLAEGPV TLYPTETHEA IATGIAAAQA GALARQWLAG
210 220 230 240 250
QERYGQPPEV YVAGGGWTEV RPEIERLLQL VGAPFGVAPV PVILQTPVLD

GLAALASAL
Length:259
Mass (Da):27,376
Last modified:March 7, 2006 - v1
Checksum:i237A4EB393E5B148
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM167904 Genomic DNA. Translation: CAJ47734.1.
RefSeqiWP_012415832.1. NC_010645.1.

Genome annotation databases

EnsemblBacteriaiCAJ47734; CAJ47734; BAV0128.
KEGGibav:BAV0128.
PATRICi21126386. VBIBorAvi43433_0134.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM167904 Genomic DNA. Translation: CAJ47734.1.
RefSeqiWP_012415832.1. NC_010645.1.

3D structure databases

ProteinModelPortaliQ2L1G9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi360910.BAV0128.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ47734; CAJ47734; BAV0128.
KEGGibav:BAV0128.
PATRICi21126386. VBIBorAvi43433_0134.

Phylogenomic databases

eggNOGiENOG4108194. Bacteria.
COG1521. LUCA.
HOGENOMiHOG000066026.
KOiK03525.
OMAiPWQHAGA.

Enzyme and pathway databases

UniPathwayiUPA00241; UER00352.
BioCyciBAVI360910:GCKI-132-MONOMER.

Family and domain databases

HAMAPiMF_01274. Pantothen_kinase_3. 1 hit.
InterProiIPR004619. Type_III_PanK.
[Graphical view]
PfamiPF03309. Pan_kinase. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOAX_BORA1
AccessioniPrimary (citable) accession number: Q2L1G9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: March 7, 2006
Last modified: September 7, 2016
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.