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Protein

Chemotaxis response regulator protein-glutamate methylesterase 2

Gene

cheB2

Organism
Bordetella avium (strain 197N)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR.UniRule annotation

Catalytic activityi

Protein L-glutamate O5-methyl ester + H2O = protein L-glutamate + methanol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei166UniRule annotation1
Active sitei192UniRule annotation1
Active sitei289UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processChemotaxis

Enzyme and pathway databases

BioCyciBAVI360910:GCKI-1688-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis response regulator protein-glutamate methylesterase 2UniRule annotation (EC:3.1.1.61UniRule annotation)
Gene namesi
Name:cheB2UniRule annotation
Ordered Locus Names:BAV1679
OrganismiBordetella avium (strain 197N)
Taxonomic identifieri360910 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
Proteomesi
  • UP000001977 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002642631 – 351Chemotaxis response regulator protein-glutamate methylesterase 2Add BLAST351

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei564-aspartylphosphateUniRule annotation1

Post-translational modificationi

Phosphorylated by CheA. Phosphorylation suppresses the inhibitory activity of the N-terminal domain.UniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi360910.BAV1679.

Structurei

3D structure databases

ProteinModelPortaliQ2L1D1.
SMRiQ2L1D1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 122Response regulatoryPROSITE-ProRule annotationAdd BLAST118
Domaini154 – 347CheB-type methylesteraseUniRule annotationAdd BLAST194

Domaini

The N-terminal regulatory domain inhibits the activity of the C-terminal effector domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CMP. Bacteria.
COG2201. LUCA.
HOGENOMiHOG000151424.
KOiK03412.
OMAiMLEMHRA.

Family and domain databases

CDDicd16432. CheB_Rec. 1 hit.
cd00156. REC. 1 hit.
Gene3Di3.40.50.180. 1 hit.
HAMAPiMF_00099. CheB_methylest. 1 hit.
InterProiView protein in InterPro
IPR035909. CheB_C.
IPR011006. CheY-like_superfamily.
IPR008248. Sig_transdc_resp-reg_CheB.
IPR000673. Sig_transdc_resp-reg_Me-estase.
IPR001789. Sig_transdc_resp-reg_receiver.
PfamiView protein in Pfam
PF01339. CheB_methylest. 1 hit.
PF00072. Response_reg. 1 hit.
PIRSFiPIRSF000876. RR_chemtxs_CheB. 1 hit.
SMARTiView protein in SMART
SM00448. REC. 1 hit.
SUPFAMiSSF52172. SSF52172. 1 hit.
SSF52738. SSF52738. 1 hit.
PROSITEiView protein in PROSITE
PS50122. CHEB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2L1D1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKIRVICVD DSALVRGLMT EIINSHPDME VVATAPDPLV ARELIKQHNP
60 70 80 90 100
DVLTLDVEMP RMDGLDFLEK LMRLRPMPVV MVSSLTERGG EITMRALELG
110 120 130 140 150
AIDFVTKPRL GIRDGLLDYS ELIADKIRAA SRARLRGPAP VAAAALPARL
160 170 180 190 200
RSPLNSSEKL VILGASTGGT EAIREVLLPL PPDSPAILIT QHMPAGFTRS
210 220 230 240 250
FAQRLDTLCA VTVREATHGE RVLPGHVYLA PGGEQHMKLG RSGANYVIEL
260 270 280 290 300
EAGEPVNRHR PSVDVLFHSA AQAAGRNAIG VLLTGMGKDG AAGLLAMKRA
310 320 330 340 350
GAYTLAQDEA SCVVFGMPRE AILLGAADEV VPLPAMSERI LMRAGDRGHR

V
Length:351
Mass (Da):37,674
Last modified:March 7, 2006 - v1
Checksum:iB2C5668E200C4937
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM167904 Genomic DNA. Translation: CAJ49287.1.
RefSeqiWP_012417348.1. NC_010645.1.

Genome annotation databases

EnsemblBacteriaiCAJ49287; CAJ49287; BAV1679.
KEGGibav:BAV1679.

Similar proteinsi

Entry informationi

Entry nameiCHEB2_BORA1
AccessioniPrimary (citable) accession number: Q2L1D1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: March 7, 2006
Last modified: November 22, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome