Q2L151 (LPXD_BORA1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UDP-3-O-acylglucosamine N-acyltransferase
EC=2.3.1.-

Gene names

Name:	lpxD
Ordered Locus Names:	BAV1744

Organism

Bordetella avium (strain 197N) [Complete proteome] [HAMAP]

Taxonomic identifier

360910 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	361 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP MF_00523
Catalytic activity	(3R)-3-hydroxyacyl-[acyl-carrier-protein] + UDP-3-O-acyl-alpha-D-glucosamine = UDP-2,3-diacyl-alpha-D-glucosamine + [acyl-carrier-protein]. HAMAP MF_00523
Pathway	Bacterial outer membrane biogenesis; LPS lipid A biosynthesis. HAMAP MF_00523
Subunit structure	Homotrimer By similarity. HAMAP MF_00523
Sequence similarities	Belongs to the transferase hexapeptide repeat family. LpxD subfamily.

Ontologies

Keywords
Biological process	Lipid A biosynthesis Lipid synthesis
Domain	Repeat
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	transferase activity, transferring acyl groups other than amino-acyl groups Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 361	361	UDP-3-O-acylglucosamine N-acyltransferase HAMAP MF_00523		PRO_0000264349
Sites
	Active site	264	1	Proton acceptor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2L151 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 98B55EBBD1A84CDE	FASTA	361	37,027
	10 20 30 40 50 60 MPVLLDSSRA PRLDALLSKG NTQGLECQID SPTGDLPLIA GIGTLASAGA QEIAFLSNPR 70 80 90 100 110 120 YQSQVASTAA AAVIVTLDVA QALRAQGSTL VFVVCRHPYL LYARLAQWFD AERRGLPPAG 130 140 150 160 170 180 VHPSAVVAPD AVIEEGASVG PQCVVDSGAR IGRGASLGPG CIVGQGSTVG ANSRLHARVT 190 200 210 220 230 240 LYDGVHVGAR AIIHSGAVLG ADGFGFAPDP TLGKGAWGKI PQLGGVTVGN DVEIGANTTI 250 260 270 280 290 300 DRGAIENTII GDGVKLDNLI MIAHNVRIGA HTAVAACVGI AGSTVIGERC IVGGAAMFSG 310 320 330 340 350 360 HLSICDDVTI SGGTPVTSSI TKPGRYTGVY PYSEHGEWQR NAAVIQQLAL LRRRVRALEK A

References

[1]

"Comparison of the genome sequence of the poultry pathogen Bordetella avium with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals extensive diversity in surface structures associated with host interaction." Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D., King N.D., Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D., Goble A., Lord A., Murphy L., Quail M.A., Rutter S., Squares R., Squares S., Woodward J., Parkhill J., Temple L.M. J. Bacteriol. 188:6002-6015(2006) [PubMed: 16885469] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 197N.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM167904 Genomic DNA. Translation: CAJ49352.1.
RefSeq	YP_786262.1. NC_010645.1.
3D structure databases
ProteinModelPortal	Q2L151.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2L151.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6267460.
GenomeReviews	Gene locus BAV1744 in contig AM167904_GR.
KEGG	bav:BAV1744.
NMPDR	fig|521.1.peg.1677.
PATRIC	21129674. VBIBorAvi43433_1758.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG469615.
OMA	CFVGKNT.
ProtClustDB	PRK00892.
Enzyme and pathway databases
BioCyc	ABAU360910:BAV1744-MONOMER.
Family and domain databases
HAMAP	MF_00523. LpxD. [Tree]
InterPro	IPR001451. Hexapep_transf. IPR018357. Hexapep_transf_CS. IPR011004. Trimer_LpxA-like. IPR007691. UDP-3-O_GlcNAc_AcTrfase. IPR020573. UDP_GlcNAc_AcTrfase_non-rep. [Graphical view]
KO	K02536.
Pfam	PF00132. Hexapep. 4 hits. PF04613. LpxD. 1 hit. [Graphical view]
SUPFAM	SSF51161. Trimer_LpxA_like. 1 hit.
TIGRFAMs	TIGR01853. Lipid_A_lpxD. 1 hit.
PROSITE	PS00101. HEXAPEP_TRANSFERASES. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LPXD_BORA1

Accession

Primary (citable) accession number: Q2L151

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
Last sequence update:	March 7, 2006
Last modified:	January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program