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Q2L147

- LPXB_BORA1

UniProt

Q2L147 - LPXB_BORA1

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Bordetella avium (strain 197N)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciBAVI360910:GCKI-1774-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:BAV1747
OrganismiBordetella avium (strain 197N)
Taxonomic identifieri360910 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
ProteomesiUP000001977: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 395395Lipid-A-disaccharide synthasePRO_0000255162Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi360910.BAV1747.

Structurei

3D structure databases

ProteinModelPortaliQ2L147.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiIARMLVN.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2L147-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLSIGMVAG EPSGDLLAGR IIGGLRAGAP DVHCAGIGGP QMQAQGFEAW
60 70 80 90 100
HPMHALTVFG YIDALKRIPS LLSIYGQTKQ RMLAERPAAF VGIDAPDFNL
110 120 130 140 150
RLELQLRQAG IPTVHFVGPS IWAWRYERIH KIRAAVSHML VLFPFEEEIY
160 170 180 190 200
QKEGIPVTYV GHPLAGVIPM RPDRAAARLR LNLDVGERVL AILPGSRSSE
210 220 230 240 250
IRTLAPRFLQ AAQLLQARDP ALCCVVPMVN PQRRAEFEQI LAQYPVQGLR
260 270 280 290 300
CITAEDVQGN GATPVAWSVM EAADAVLVAS GTATLETALY KRPMVISYVL
310 320 330 340 350
TPWMRRIMAW KSGQQRPYLP WVGLPNVLLK DFAVPELLQD DATPEKLAEA
360 370 380 390
AWTALTDKDN AARIEARFTA MHEELLRDTP ALAAKAILEV AHGAG
Length:395
Mass (Da):43,263
Last modified:March 7, 2006 - v1
Checksum:iF33ADA25AC4537C4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM167904 Genomic DNA. Translation: CAJ49355.1.
RefSeqiYP_786265.1. NC_010645.1.

Genome annotation databases

EnsemblBacteriaiCAJ49355; CAJ49355; BAV1747.
GeneIDi6267311.
KEGGibav:BAV1747.
PATRICi21129680. VBIBorAvi43433_1761.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM167904 Genomic DNA. Translation: CAJ49355.1 .
RefSeqi YP_786265.1. NC_010645.1.

3D structure databases

ProteinModelPortali Q2L147.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360910.BAV1747.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAJ49355 ; CAJ49355 ; BAV1747 .
GeneIDi 6267311.
KEGGi bav:BAV1747.
PATRICi 21129680. VBIBorAvi43433_1761.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi IARMLVN.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci BAVI360910:GCKI-1774-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparison of the genome sequence of the poultry pathogen Bordetella avium with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals extensive diversity in surface structures associated with host interaction."
    Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D., King N.D., Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D., Goble A., Lord A., Murphy L., Quail M.A., Rutter S., Squares R., Squares S., Woodward J., Parkhill J., Temple L.M.
    J. Bacteriol. 188:6002-6015(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 197N.

Entry informationi

Entry nameiLPXB_BORA1
AccessioniPrimary (citable) accession number: Q2L147
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 7, 2006
Last modified: October 29, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3