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Protein

Glutamate 5-kinase

Gene

proB

Organism
Bordetella avium (strain 197N)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.UniRule annotation

Catalytic activityi

ATP + L-glutamate = ADP + L-glutamate 5-phosphate.UniRule annotation

Pathwayi: L-proline biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-glutamate 5-semialdehyde from L-glutamate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamate 5-kinase (proB)
  2. Gamma-glutamyl phosphate reductase (proA)
This subpathway is part of the pathway L-proline biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-glutamate 5-semialdehyde from L-glutamate, the pathway L-proline biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei18ATPUniRule annotation1
Binding sitei58SubstrateUniRule annotation1
Binding sitei145SubstrateUniRule annotation1
Binding sitei157Substrate; via amide nitrogenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi177 – 178ATPUniRule annotation2
Nucleotide bindingi219 – 225ATPUniRule annotation7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processAmino-acid biosynthesis, Proline biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBAVI360910:G1GJZ-262-MONOMER
UniPathwayiUPA00098; UER00359

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate 5-kinaseUniRule annotation (EC:2.7.2.11UniRule annotation)
Alternative name(s):
Gamma-glutamyl kinaseUniRule annotation
Short name:
GKUniRule annotation
Gene namesi
Name:proBUniRule annotation
Ordered Locus Names:BAV0256
OrganismiBordetella avium (strain 197N)
Taxonomic identifieri360910 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
Proteomesi
  • UP000001977 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002529711 – 377Glutamate 5-kinaseAdd BLAST377

Interactioni

Protein-protein interaction databases

STRINGi360910.BAV0256

Structurei

3D structure databases

ProteinModelPortaliQ2L067
SMRiQ2L067
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini284 – 362PUAUniRule annotationAdd BLAST79

Sequence similaritiesi

Belongs to the glutamate 5-kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CGT Bacteria
COG0263 LUCA
HOGENOMiHOG000246368
KOiK00931
OMAiTHEIRFG

Family and domain databases

Gene3Di2.30.130.101 hit
3.40.1160.101 hit
HAMAPiMF_00456 ProB, 1 hit
InterProiView protein in InterPro
IPR036393 AceGlu_kinase-like_sf
IPR001048 Asp/Glu/Uridylate_kinase
IPR001057 Glu/AcGlu_kinase
IPR011529 Glu_5kinase
IPR005715 Glu_5kinase/COase_Synthase
IPR019797 Glutamate_5-kinase_CS
IPR002478 PUA
IPR015947 PUA-like_sf
IPR036974 PUA_sf
PfamiView protein in Pfam
PF00696 AA_kinase, 1 hit
PF01472 PUA, 1 hit
PIRSFiPIRSF000729 GK, 1 hit
PRINTSiPR00474 GLU5KINASE
SMARTiView protein in SMART
SM00359 PUA, 1 hit
SUPFAMiSSF53633 SSF53633, 1 hit
SSF88697 SSF88697, 1 hit
TIGRFAMsiTIGR01027 proB, 1 hit
PROSITEiView protein in PROSITE
PS00902 GLUTAMATE_5_KINASE, 1 hit
PS50890 PUA, 1 hit

Sequencei

Sequence statusi: Complete.

Q2L067-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTASPISVIA SANRLVAKVG SSLVTNEGRG LDRAAVAHWA AQIAALHKQG
60 70 80 90 100
RQVVLVSSGA IAEGMARLGW RKRPSVMHEL QAAAAVGQMG LCQAYEAAFA
110 120 130 140 150
EHGLRTAQIL LTHEDLADRH RYLNARSTLF ALLRMGVVPI VNENDTVVTD
160 170 180 190 200
EIRLGDNDTL GALVTNLIEA DSLIILTDQR GLYEADPRKN PDARFISHAQ
210 220 230 240 250
AGDTALEAMA GGAGSGVGTG GMLTKILAAK RAAHSGAHTV IASGRERNVL
260 270 280 290 300
TRLAQGECIG TELQATLPVW SARKQWMADH LRLRGRLVLD EGAVQALLNE
310 320 330 340 350
GKSLLPIGVT EVQGDFERGD VVACVDASGR ECARGLVNYA SADARRIMRH
360 370
PSSEITQILG SMTAPELMHR DNLVITE
Length:377
Mass (Da):40,201
Last modified:March 7, 2006 - v1
Checksum:i972C180FEED79088
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM167904 Genomic DNA Translation: CAJ47861.1
RefSeqiWP_012415959.1, NC_010645.1

Genome annotation databases

EnsemblBacteriaiCAJ47861; CAJ47861; BAV0256
KEGGibav:BAV0256

Similar proteinsi

Entry informationi

Entry nameiPROB_BORA1
AccessioniPrimary (citable) accession number: Q2L067
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: March 7, 2006
Last modified: February 28, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome