Q2L048 (ADC_BORA1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable acetoacetate decarboxylase
Short name=AAD
Short name=ADC
EC=4.1.1.4

Gene names

Name:	adc
Ordered Locus Names:	BAV0264

Organism

Bordetella avium (strain 197N) [Complete proteome] [HAMAP]

Taxonomic identifier

360910 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	246 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of acetoacetate to acetone and carbon dioxide By similarity. HAMAP MF_00597
Catalytic activity	Acetoacetate = acetone + CO2. HAMAP MF_00597
Sequence similarities	Belongs to the ADC family.

Ontologies

Keywords
Ligand	Schiff base
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	acetoacetate decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 246	246	Probable acetoacetate decarboxylase HAMAP MF_00597		PRO_1000025630
Sites
	Active site	116	1	Schiff-base intermediate with acetoacetate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2L048 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 89E44F015E68CCDC	FASTA	246	27,282
	10 20 30 40 50 60 MNIDTVRANA FAMPLTSPAF PMGPYRFVKR EFFVITYRTD PEALRSVVPE PLAVTQPLVH 70 80 90 100 110 120 YEFIRMPDST GFGDYTESGQ VIPVEYEGVA GSYTHAMYLN DHPPIAGGRE LWGFPKKLAL 130 140 150 160 170 180 PTLKVHTDTL VGTLDYGPIR VATGTMGYKH EEVDIVEQAR HLSAPNFLLK IIPHVDCSPR 190 200 210 220 230 240 ICELVRYYLE DIRVYGAWSG PAALELAPHA LAPVADLPVL EVVGARHFIA DLTLGLGEVV YDYLAK

References

[1]

"Comparison of the genome sequence of the poultry pathogen Bordetella avium with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals extensive diversity in surface structures associated with host interaction." Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D., King N.D., Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D., Goble A., Lord A., Murphy L., Quail M.A., Rutter S., Squares R., Squares S., Woodward J., Parkhill J., Temple L.M. J. Bacteriol. 188:6002-6015(2006) [PubMed: 16885469] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 197N.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM167904 Genomic DNA. Translation: CAJ47869.1.
RefSeq	YP_784802.1. NC_010645.1.
3D structure databases
ProteinModelPortal	Q2L048.
SMR	Q2L048. Positions 2-245.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2L048.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6266695.
GenomeReviews	Gene locus BAV0264 in contig AM167904_GR.
KEGG	bav:BAV0264.
NMPDR	fig|521.1.peg.2632.
PATRIC	21126674. VBIBorAvi43433_0277.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG294597.
OMA	PGPYRFV.
ProtClustDB	PRK02265.
Enzyme and pathway databases
BioCyc	ABAU360910:BAV0264-MONOMER.
Family and domain databases
HAMAP	MF_00597. ADC. [Tree]
InterPro	IPR010451. Acetoacetate_decarboxylase. IPR023653. Acetoacetate_decarboxylase_bac. IPR023375. Acetoacetate_decarboxylase_dom. [Graphical view]
Gene3D	G3DSA:2.40.400.10. G3DSA:2.40.400.10. 1 hit.
KO	K01574.
Pfam	PF06314. ADC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADC_BORA1

Accession

Primary (citable) accession number: Q2L048

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	March 7, 2006
Last modified:	January 25, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program