Q2KZ46 (F16PA_BORA1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fructose-1,6-bisphosphatase class 1
Short name=FBPase class 1
EC=3.1.3.11

Alternative name(s):
D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1

Gene names

Name:	fbp
Ordered Locus Names:	BAV2158

Organism

Bordetella avium (strain 197N) [Complete proteome] [HAMAP]

Taxonomic identifier

360910 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	338 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate. HAMAP MF_01855
Cofactor	Binds 2 magnesium ions per subunit By similarity. HAMAP MF_01855
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_01855
Subunit structure	Homotetramer By similarity. HAMAP MF_01855
Subcellular location	Cytoplasm Potential HAMAP MF_01855.
Sequence similarities	Belongs to the FBPase class 1 family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	fructose 1,6-bisphosphate 1-phosphatase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 338	338	Fructose-1,6-bisphosphatase class 1 HAMAP MF_01855		PRO_0000364467
Regions
	Region	116 – 119	4	Substrate binding By similarity
Sites
	Metal binding	91	1	Magnesium 1 By similarity
	Metal binding	113	1	Magnesium 1 By similarity
	Metal binding	113	1	Magnesium 2 By similarity
	Metal binding	115	1	Magnesium 1; via carbonyl oxygen By similarity
	Metal binding	116	1	Magnesium 2 By similarity
	Metal binding	282	1	Magnesium 2 By similarity
	Binding site	210	1	Substrate By similarity
	Binding site	276	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2KZ46 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 73D5E19EF1112861	FASTA	338	37,262
	10 20 30 40 50 60 MKRKTLTQYL VEQQRSAQAL APEVRLLIEV VARACKAISH AVGKGALGGV LGSLESENVQ 70 80 90 100 110 120 GEVQKKLDVL SNEILLEANE WGGHLAAMAS EEMETIHRIP NRYPKGEYLL LFDPLDGSSN 130 140 150 160 170 180 IDVNVSIGTI FSVLRAPHHV SGAEVSEADF LQPGRDQVAA GYAVYGPQTM LVLTIGQGVV 190 200 210 220 230 240 GFTLDREMGS WVLTHEKISI PADTKEFAIN MSNMRHWDAP VKRYIDECLA GKTGPLGKDY 250 260 270 280 290 300 NMRWIASMVA DVHRILTRGG IFMYPWDARE PGKAGKLRLM YEANPMSFIV EQAGGASING 310 320 330 TQRILDIQPE QLHQRVSVIL GSKNEVERVG RYHSESLT

References

[1]

"Comparison of the genome sequence of the poultry pathogen Bordetella avium with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals extensive diversity in surface structures associated with host interaction." Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D., King N.D., Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D., Goble A., Lord A., Murphy L., Quail M.A., Rutter S., Squares R., Squares S., Woodward J., Parkhill J., Temple L.M. J. Bacteriol. 188:6002-6015(2006) [PubMed: 16885469] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 197N.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM167904 Genomic DNA. Translation: CAJ49768.1.
RefSeq	YP_786674.1. NC_010645.1.
3D structure databases
HSSP	HSSP built from PDB template 2GQ1 based on UniProtKB P0A993.
ProteinModelPortal	Q2KZ46.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2KZ46.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6267501.
GenomeReviews	Gene locus BAV2158 in contig AM167904_GR.
KEGG	bav:BAV2158.
NMPDR	fig|521.1.peg.1401.
PATRIC	21130521. VBIBorAvi43433_2176.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG731261.
OMA	HWEAPVQ.
ProtClustDB	PRK09293.
Enzyme and pathway databases
BioCyc	ABAU360910:BAV2158-MONOMER.
Family and domain databases
HAMAP	MF_01855. FBPase_class1. [Tree]
InterPro	IPR000146. FBPase_class-1/SBPase. [Graphical view]
KO	K03841.
PANTHER	PTHR11556. In_FB_phphtase. 1 hit.
Pfam	PF00316. FBPase. 1 hit. [Graphical view]
PIRSF	PIRSF000904. FBPtase_SBPase. 1 hit.
PRINTS	PR00115. F16BPHPHTASE.
PROSITE	PS00124. FBPASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

F16PA_BORA1

Accession

Primary (citable) accession number: Q2KZ46

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 3, 2009
Last sequence update:	March 7, 2006
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program