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Q2KZ16 (GCH4_BORA1) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase FolE2

EC=3.5.4.16
Gene names
Name:folE2
Ordered Locus Names:BAV2176
OrganismBordetella avium (strain 197N) [Complete proteome] [HAMAP]
Taxonomic identifier360910 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella

Protein attributes

Sequence length265 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process7,8-dihydroneopterin 3'-triphosphate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionGTP cyclohydrolase I activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 265265GTP cyclohydrolase FolE2 HAMAP-Rule MF_01527
PRO_0000289474

Sites

Site1561May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2KZ16 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: 8FBD29CFDCAB729C

FASTA26529,187
        10         20         30         40         50         60 
MNSPIDPAIV MPDVQSSADT RHIQIQRVGI RGVRHPMLVV AGDGSAQATV ANWTLTVALP 

        70         80         90        100        110        120 
AEEKGTHMSR FVALLEKYRA TPMTPALFSQ MAREMLPLLH AERGDLTAAF PYFINKSAPV 

       130        140        150        160        170        180 
SGVQSLLDYE VIWTARAAGD EVEFELRVQV PVTSLCPCSK AISEYGAHNQ RSHVTVSAVM 

       190        200        210        220        230        240 
EGDVAMDAII RLVEDEGSCE LWGLLKRPDE KYVTERAYDN PKFVEDLVRD VAARLKAHPS 

       250        260 
VARFCVEAEN FESIHNHSAY AVVEG 

« Hide

References

[1]"Comparison of the genome sequence of the poultry pathogen Bordetella avium with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals extensive diversity in surface structures associated with host interaction."
Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D., King N.D., Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D., Goble A., Lord A., Murphy L., Quail M.A., Rutter S., Squares R., Squares S., Woodward J., Parkhill J., Temple L.M.
J. Bacteriol. 188:6002-6015(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 197N.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM167904 Genomic DNA. Translation: CAJ49785.1.
RefSeqYP_786690.1. NC_010645.1.

3D structure databases

ProteinModelPortalQ2KZ16.
SMRQ2KZ16. Positions 22-264.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING360910.BAV2176.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6267714.
KEGGbav:BAV2176.
PATRIC21130561. VBIBorAvi43433_2196.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1469.
HOGENOMHOG000280679.
KOK09007.
OMAINMYVDL.
OrthoDBEOG6X6RBH.
ProtClustDBPRK13674.

Enzyme and pathway databases

BioCycBAVI360910:GCKI-2211-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_01527_B. GTP_cyclohydrol_B.
InterProIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH4_BORA1
AccessionPrimary (citable) accession number: Q2KZ16
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 7, 2006
Last modified: February 19, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways