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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Bordetella avium (strain 197N)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase (folE)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei156May be catalytically importantUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyciBAVI360910:G1GJZ-2213-MONOMER
UniPathwayiUPA00848; UER00151

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:BAV2176
OrganismiBordetella avium (strain 197N)
Taxonomic identifieri360910 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
Proteomesi
  • UP000001977 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002894741 – 265GTP cyclohydrolase FolE2Add BLAST265

Interactioni

Protein-protein interaction databases

STRINGi360910.BAV2176

Structurei

3D structure databases

ProteinModelPortaliQ2KZ16
SMRiQ2KZ16
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DZA Bacteria
COG1469 LUCA
HOGENOMiHOG000280679
KOiK09007
OMAiHNQRGRG

Family and domain databases

HAMAPiMF_01527_B GTP_cyclohydrol_B, 1 hit
InterProiView protein in InterPro
IPR022838 GTP_cyclohydrolase_FolE2
IPR003801 GTP_cyclohydrolase_FolE2/MptA
PANTHERiPTHR36445 PTHR36445, 1 hit
PfamiView protein in Pfam
PF02649 GCHY-1, 1 hit

Sequencei

Sequence statusi: Complete.

Q2KZ16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSPIDPAIV MPDVQSSADT RHIQIQRVGI RGVRHPMLVV AGDGSAQATV
60 70 80 90 100
ANWTLTVALP AEEKGTHMSR FVALLEKYRA TPMTPALFSQ MAREMLPLLH
110 120 130 140 150
AERGDLTAAF PYFINKSAPV SGVQSLLDYE VIWTARAAGD EVEFELRVQV
160 170 180 190 200
PVTSLCPCSK AISEYGAHNQ RSHVTVSAVM EGDVAMDAII RLVEDEGSCE
210 220 230 240 250
LWGLLKRPDE KYVTERAYDN PKFVEDLVRD VAARLKAHPS VARFCVEAEN
260
FESIHNHSAY AVVEG
Length:265
Mass (Da):29,187
Last modified:March 7, 2006 - v1
Checksum:i8FBD29CFDCAB729C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM167904 Genomic DNA Translation: CAJ49785.1
RefSeqiWP_012417837.1, NC_010645.1

Genome annotation databases

EnsemblBacteriaiCAJ49785; CAJ49785; BAV2176
KEGGibav:BAV2176

Similar proteinsi

Entry informationi

Entry nameiGCH4_BORA1
AccessioniPrimary (citable) accession number: Q2KZ16
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 7, 2006
Last modified: March 28, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health