Reviewed, UniProtKB/Swiss-Prot Q2KZ15 (DXS_BORA1)

Names and origin

Protein names

Recommended name:
    1-deoxy-D-xylulose-5-phosphate synthase
    EC=2.2.1.7
Alternative name(s):
    1-deoxyxylulose-5-phosphate synthase
      Short name=DXP synthase
      Short name=DXPS

Gene names

Name:	dxs
Ordered Locus Names:	BAV2177

Organism

Bordetella avium (strain 197N) [Complete proteome] [HAMAP]

Taxonomic identifier

360910 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	620 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315
Catalytic activity	Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315
Cofactor	Binds 1 thiamine pyrophosphate per subunit By similarity. HAMAP MF_00315
Pathway	Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315
Subunit structure	Homodimer By similarity. HAMAP MF_00315
Sequence similarities	Belongs to the transketolase family. DXPS subfamily.

Ontologies

Keywords
Biological process	Isoprene biosynthesis Thiamine biosynthesis
Ligand	Thiamine pyrophosphate
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	terpenoid biosynthetic process Inferred from electronic annotation. Source: HAMAP thiamin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	1-deoxy-D-xylulose-5-phosphate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 620	620	1-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315		PRO_0000256384

Sequences

	Sequence		Length	Mass (Da)
	Q2KZ15-1 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 9D9952F633784B43	FASTA	620	66,373
	10 20 30 40 50 60 MTTEHLDRIH SPADLRKLDR RDLKPIADEL RAFVLESVSK TGGHLSSNLG TVELTLALHY 70 80 90 100 110 120 VFDTPHDRIV WDVGHQTYPH KILTGRRDRM ATLRQEGGIS GFPKRSESEY DDFGTAHSST 130 140 150 160 170 180 SISAALGMAV ASRNAGVARQ HIAVIGDGAM SAGMAFEAMN NAGVTSDINL LVILNDNDMS 190 200 210 220 230 240 ISPPVGALNR YLARLMSGRF YAAAKNMGKA VLQHVPPVLE LARRFEEHAK GMITSATMFE 250 260 270 280 290 300 EFGFNYVGPI DGHDLDALIP TLQNLKTLQG LQFLHVVTRK GRGYKLAEVD PVLYHGPGKF 310 320 330 340 350 360 DPAVGIQAAK TPAKRTFTQV FGAWLCDQAE ADPRLVGITP AMREGSGLVE FEQRFPKRYF 370 380 390 400 410 420 DVGIAEQHAV TFAAGLACEG QKPVVAIYST FLQRGYDQVV HDVALQNLDV TFALDRAGLV 430 440 450 460 470 480 GADGATHAGN YDIAFLRCVP NMVIATPSDE NETRLLLSTC YAYPGPASVR YPRGAGCGAA 490 500 510 520 530 540 VSAGLDTVPL GKGVVRRRGA RIAIMGFGTL VPAALAAAEK LDATVADMRF VKPLDVELLR 550 560 570 580 590 600 ELAATHEALV TLEDAAVMGG AGSAVTEALN MAGLTLPVLQ LGLPDVFIDH GDQAALLAGV 610 620 GLDAAGIERS VRERFASLLG

References

[1]

"Comparison of the genome sequence of the poultry pathogen Bordetella avium with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals extensive diversity in surface structures associated with host interaction." Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D., King N.D., Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D., Goble A., Lord A., Murphy L., Quail M.A., Rutter S., Squares R., Squares S., Woodward J., Parkhill J., Temple L.M. J. Bacteriol. 188:6002-6015(2006) [PubMed: 16885469] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM167904 Genomic DNA. Translation: CAJ49786.1.
RefSeq	YP_786691.1.
3D structure databases
SMR	Q2KZ15. Positions 5-615.
ModBase	Search...
Genome annotation databases
GeneID	6265833.
GenomeReviews	Gene locus BAV2177 in contig AM167904_GR.
KEGG	bav:BAV2177.
NMPDR	fig|521.1.peg.1383.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG571647.
OMA	QRFPDRY.
Family and domain databases
HAMAP	MF_00315. DXP_synth. [Tree]
InterPro	IPR005477. Dxylulose-5-P_synthase. IPR009014. Transketo_C/Pyr-ferredox_oxred. IPR015941. Transketolase-like_C. IPR005475. Transketolase-like_Pyr-bd. IPR020826. Transketolase_BS. IPR005476. Transketolase_C. IPR005474. Transketolase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.920. Transketo_C_like. 1 hit.
Pfam	PF02779. Transket_pyr. 1 hit. PF02780. Transketolase_C. 1 hit. PF00456. Transketolase_N. 1 hit. [Graphical view]
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
TIGRFAMs	TIGR00204. dxs. 1 hit.
PROSITE	PS00801. TRANSKETOLASE_1. 1 hit. PS00802. TRANSKETOLASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DXS_BORA1

Accession

Primary (citable) accession number: Q2KZ15

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	March 7, 2006
Last modified:	February 9, 2010
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)