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Reviewed, UniProtKB/Swiss-Prot Q2KYW5 (TRMB_BORA1)

Last modified June 16, 2009. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    tRNA (guanine-N(7)-)-methyltransferase
    EC=2.1.1.33
Alternative name(s):
    tRNA(m7G46)-methyltransferase
Gene names
Name: trmB
Ordered Locus Names: BAV0455
OrganismBordetella avium (strain 197N) [Complete proteome] [HAMAP]
Taxonomic identifier360910 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

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Protein attributes

Sequence length256 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.

Catalytic activity

S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N(7)-methylguanine. HAMAP MF_01057

Pathway

tRNA modification; N(7)-methylguanine-tRNA biosynthesis. HAMAP MF_01057

Sequence similarities

Belongs to the methyltransferase superfamily. TrmB family.

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Ontologies

Keywords
   Biological processtRNA processing
   LigandS-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processtRNA modification

Inferred from electronic annotation. Source: HAMAP

   Molecular functiontRNA (guanine-N7-)-methyltransferase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 256256tRNA (guanine-N(7)-)-methyltransferase HAMAP MF_01057
PRO_0000288126

Regions

Region234 – 2374Substrate binding Potential

Sites

Binding site881S-adenosyl-L-methionine By similarity
Binding site1131S-adenosyl-L-methionine By similarity
Binding site1401S-adenosyl-L-methionine By similarity
Binding site1631S-adenosyl-L-methionine By similarity
Binding site1671Substrate By similarity
Binding site1991Substrate Potential

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Sequences

Sequence LengthMass (Da)Tools
Q2KYW5-1 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: D79ADFA612E3C52D

FASTA25628,553
        10         20         30         40         50         60 
MNANTPTPID GQPTELTPST QAALEPANHA PASPGATHIR SFVHRRGHIT QRQRDALEQL 

        70         80         90        100        110        120 
MGKWAIPYAP RPLNPATAFG REAPTILEIG FGMGETTEKI ALARPEDNFL GVEVFNAGVG 

       130        140        150        160        170        180 
SMLHRIETSQ IPNVRIIQHD AVEVVRDMIA PDSLAGVHVY FPDPWPKKRH HKRRLLQPAF 

       190        200        210        220        230        240 
VQLLASRIKP GGYLHCATDW QDYAVQMLEV LGGEALLENT AQDYAERPAY RPQTKFETRG 

       250 
LRLGHGVWDL IFKRKA

« Hide

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References

[1]"Comparison of the genome sequence of the poultry pathogen Bordetella avium with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals extensive diversity in surface structures associated with host interaction."
Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D., King N.D., Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D., Goble A., Lord A., Murphy L., Quail M.A., Rutter S., Squares R., Squares S., Woodward J., Parkhill J., Temple L.M.
J. Bacteriol. 188:6002-6015(2006) [PubMed: 16885469] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

AM167904 Genomic DNA. Translation: CAJ48060.1.
RefSeqYP_784989.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID6267538.
GenomeReviewsGene locus BAV0455 in contig AM167904_GR.
KEGGbav:BAV0455.
NMPDRfig|521.1.peg.2611.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ2KYW5.
OMAQ2KYW5. TKFENRG.

Family and domain databases

HAMAPMF_01057.
[Tree]
InterProIPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PANTHERPTHR23417:SF1. Methyltransf_4. 1 hit.
PfamPF02390. Methyltransf_4. 1 hit.
[Graphical view]
TIGRFAMsTIGR00091. CHP91. 1 hit.
ProtoNetSearch...

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Entry information

Entry nameTRMB_BORA1
AccessionPrimary (citable) accession number: Q2KYW5
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 7, 2006
Last modified: June 16, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents