Q2KYM2 (GCST_BORA1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aminomethyltransferase
EC=2.1.2.10

Alternative name(s):
Glycine cleavage system T protein

Gene names

Name:	gcvT
Ordered Locus Names:	BAV0491

Organism

Bordetella avium (strain 197N) [Complete proteome] [HAMAP]

Taxonomic identifier

360910 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	366 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the GcvT family.

Ontologies

Keywords
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: EC transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 366	366	Aminomethyltransferase HAMAP MF_00259		PRO_1000047647

Sequences

	Sequence		Length	Mass (Da)
	Q2KYM2 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 9D0249FDC5E6BBBE	FASTA	366	39,328
	10 20 30 40 50 60 MSASLKHTPL AETHLAAGAR MVDFGGWEMP LAYGSQLEEH HAVRQDAGMF DVSHMLNADI 70 80 90 100 110 120 TGPDATAFLR YLVANDVARL NTPGKALYSC MLNPQGGVID DLIIYYFAPD SWRVVVNAGT 130 140 150 160 170 180 AEKDMAWMAR VAAAGNFDVV ITPRRDLAMI AVQGPNARAK VWAARPAWQP ASEGLGPFTA 190 200 210 220 230 240 AILPEDTLVA RTGYTGEDGF EIVLPASAAV ALWQDLVAQG VRPCGLGARD TLRLEAGMNL 250 260 270 280 290 300 YGQDMDELVQ PNQAGLSWTV SLKDAERRFI GRDALEQFAT PCAFLGLKLS ERGVMRAHMA 310 320 330 340 350 360 VRTPQGMGLT TSGTMSPTLG VSIAFARLPL DVQPGSAVEV DIRGKWVPAL VCKLPFVRNG KAVEHS

References

[1]

"Comparison of the genome sequence of the poultry pathogen Bordetella avium with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals extensive diversity in surface structures associated with host interaction." Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D., King N.D., Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D., Goble A., Lord A., Murphy L., Quail M.A., Rutter S., Squares R., Squares S., Woodward J., Parkhill J., Temple L.M. J. Bacteriol. 188:6002-6015(2006) [PubMed: 16885469] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 197N.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM167904 Genomic DNA. Translation: CAJ48096.1.
RefSeq	YP_785024.1. NC_010645.1.
3D structure databases
HSSP	HSSP built from PDB template 1VLO based on UniProtKB P27248.
ProteinModelPortal	Q2KYM2.
SMR	Q2KYM2. Positions 7-364.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2KYM2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6264780.
GenomeReviews	Gene locus BAV0491 in contig AM167904_GR.
KEGG	bav:BAV0491.
NMPDR	fig|521.1.peg.1055.
PATRIC	21127132. VBIBorAvi43433_0502.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG299834.
OMA	KALYGGM.
ProtClustDB	PRK00389.
Enzyme and pathway databases
BioCyc	ABAU360910:BAV0491-MONOMER.
Family and domain databases
HAMAP	MF_00259. GcvT. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. IPR022903. NH2_Me_Trfase. [Graphical view]
KO	K00605.
PANTHER	PTHR13847:SF5. PTHR13847:SF5. 1 hit.
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. GcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_BORA1

Accession

Primary (citable) accession number: Q2KYM2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	March 7, 2006
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program