ID   TRUA_BORA1              Reviewed;         267 AA.
AC   Q2KYM0;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   16-JUN-2009, entry version 23.
DE   RecName: Full=tRNA pseudouridine synthase A;
DE            EC=5.4.99.12;
DE   AltName: Full=tRNA-uridine isomerase I;
DE   AltName: Full=tRNA pseudouridylate synthase I;
GN   Name=truA; OrderedLocusNames=BAV2265;
OS   Bordetella avium (strain 197N).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Bordetella.
OX   NCBI_TaxID=360910;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16885469; DOI=10.1128/JB.01927-05;
RA   Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D.,
RA   King N.D., Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D.,
RA   Goble A., Lord A., Murphy L., Quail M.A., Rutter S., Squares R.,
RA   Squares S., Woodward J., Parkhill J., Temple L.M.;
RT   "Comparison of the genome sequence of the poultry pathogen Bordetella
RT   avium with those of B. bronchiseptica, B. pertussis, and B.
RT   parapertussis reveals extensive diversity in surface structures
RT   associated with host interaction.";
RL   J. Bacteriol. 188:6002-6015(2006).
CC   -!- FUNCTION: Formation of pseudouridine at positions 38, 39 and 40 in
CC       the anticodon stem and loop of transfer RNAs (By similarity).
CC   -!- CATALYTIC ACTIVITY: tRNA uridine = tRNA pseudouridine.
CC   -!- SIMILARITY: Belongs to the tRNA pseudouridine synthase truA
CC       family.
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DR   EMBL; AM167904; CAJ49875.1; -; Genomic_DNA.
DR   RefSeq; YP_786779.1; -.
DR   GeneID; 6267897; -.
DR   GenomeReviews; AM167904_GR; BAV2265.
DR   KEGG; bav:BAV2265; -.
DR   NMPDR; fig|521.1.peg.160; -.
DR   HOGENOM; Q2KYM0; -.
DR   OMA; Q2KYM0; RRYRYTI.
DR   GO; GO:0009982; F:pseudouridine synthase activity; IEA:HAMAP.
DR   GO; GO:0031119; P:tRNA pseudouridine synthesis; IEA:HAMAP.
DR   HAMAP; MF_00171; -; 1.
DR   InterPro; IPR001406; tRNA_psdUrid_synth.
DR   Gene3D; G3DSA:3.30.70.580; PseudoU_synth_1; 1.
DR   Gene3D; G3DSA:3.30.70.660; PseudoU_synth_1; 1.
DR   PANTHER; PTHR11142; PseudoU_synth_1; 1.
DR   Pfam; PF01416; PseudoU_synth_1; 2.
DR   PIRSF; PIRSF001430; tRNA_psdUrid_synth; 1.
DR   TIGRFAMs; TIGR00071; hisT_truA; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Isomerase; tRNA processing.
FT   CHAIN         1    267       tRNA pseudouridine synthase A.
FT                                /FTId=PRO_1000017043.
FT   ACT_SITE     54     54       Nucleophile (By similarity).
SQ   SEQUENCE   267 AA;  29683 MW;  BCF8CCFD9CDA130D CRC64;
     MTRIALGLSY DGSSWQGWQT QPHGQTVQDT LEAALGQFSG TGAPLDTLCA GRTDTGVHAA
     MQVVHVDTHL NRRAESWVRG VNAFLPSSIS IHWAKEVGED FHARFSARSR TYVYLLWRGR
     VRPALWAHRA GWCFQPLDVT AMRQAAQALL GEHDFSSFRS SQCQARHPVR HLTRLDIAER
     GSFLVFTLQA NAFLHHMVRN IMGALLQIGQ GRESVDWMAS LLRARDRRLG APTFSPDGLY
     LSAIDYPTLF ELPDLDGGSS LLAPFTA
//