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Q2KYL7

- GCSP_BORA1

UniProt

Q2KYL7 - GCSP_BORA1

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Bordetella avium (strain 197N)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (07 Mar 2006)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciBAVI360910:GCKI-503-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:BAV0493
    OrganismiBordetella avium (strain 197N)
    Taxonomic identifieri360910 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
    ProteomesiUP000001977: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 955955Glycine dehydrogenase (decarboxylating)PRO_1000045566Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei702 – 7021N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi360910.BAV0493.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2KYL7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiTAYLTHP.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q2KYL7-1 [UniParc]FASTAAdd to Basket

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    MSRALDTHSD FIPRHIGPSE ADQAKMLATI GCSSLDALLE EVVPPRIRNQ    50
    APLALPGARS EPDVLAELKQ MAARNKVFRN YIGQGYYGTH TPNVVLRNVL 100
    ENPAWYTAYT PYQPEISQGR LEALLNYQTM VADLTGLDIS NASLLDEGTA 150
    AAEAMTLARR SAKSKSAVFF VSQHCHPQTI EVVRTRAQGL DIDVLVGDES 200
    QGLPECFGVL LQYPHSLGGV VNYRELAEAA HAQGAVVACA TDLLALALLT 250
    PPGEWGADIA VGTAQRFGVP FGFGGPHAGF MACRDAFKRN MPGRLVGVSK 300
    DAQGNPALRL ALQTREQHIR REKATSNICT AQVLLAVMAG LYAVWHGPAG 350
    LRRIATRVHT FAGVLRQHVQ ALGLTVENDS YFDTLLINTG PATPAVLRAA 400
    ECAHINLRRV DAGRVAVSID ETVTVEDLQA LINVFAAGLG KDDITLDAAT 450
    LAPEAGLPAG TVRTSPILSH PVFSSVQSET DMLRYLRKLA DKDLALDRSM 500
    IPLGSCTMKL NATAEMIPIT WPEFALIHPF APADQTAGYR ELIERLSAAL 550
    CEITGYDNIS LQPNSGAQGE YAGLLAIRGY HQARGEHQRN ICLIPSSAHG 600
    TNPASAQLAG MDVVVVASDD HGNVDLDDLR AKIEQVGDRL AALMITYPST 650
    HGVFEETVTE ICERVHAAGG QVYLDGANMN AMVGVAKPGK FGSDVSHLNL 700
    HKTFCIPHGG GGPGVGPVAV RAHLAPYLPG VLNEQGKLDA EAKVGPVSAA 750
    PYGSAGILAI PFVYISLMGA EGLRRATEVA ILNANYVATR LREYYPVLYA 800
    GRHGRVAHEC ILDIRPLKES IGISAEDIAK RLMDYGFHAP TMSFPVAGTL 850
    MVEPTESEGL AELERFIDAM IAIRAEVAQV ERGERDREDN VLKNAPHTAQ 900
    MLLAEEWHHA YPRQQAAYPL ASLRDGKYWP PVARVDNAYG DRNLVCSCLP 950
    IEAYI 955
    Length:955
    Mass (Da):102,819
    Last modified:March 7, 2006 - v1
    Checksum:i93E0C5A398CC62FD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM167904 Genomic DNA. Translation: CAJ48098.1.
    RefSeqiWP_012416189.1. NC_010645.1.
    YP_785026.1. NC_010645.1.

    Genome annotation databases

    GeneIDi6267060.
    KEGGibav:BAV0493.
    PATRICi21127136. VBIBorAvi43433_0504.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM167904 Genomic DNA. Translation: CAJ48098.1 .
    RefSeqi WP_012416189.1. NC_010645.1.
    YP_785026.1. NC_010645.1.

    3D structure databases

    ProteinModelPortali Q2KYL7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 360910.BAV0493.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 6267060.
    KEGGi bav:BAV0493.
    PATRICi 21127136. VBIBorAvi43433_0504.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi TAYLTHP.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci BAVI360910:GCKI-503-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Comparison of the genome sequence of the poultry pathogen Bordetella avium with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals extensive diversity in surface structures associated with host interaction."
      Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D., King N.D., Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D., Goble A., Lord A., Murphy L., Quail M.A., Rutter S., Squares R., Squares S., Woodward J., Parkhill J., Temple L.M.
      J. Bacteriol. 188:6002-6015(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 197N.

    Entry informationi

    Entry nameiGCSP_BORA1
    AccessioniPrimary (citable) accession number: Q2KYL7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3