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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Bordetella avium (strain 197N)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciBAVI360910:GCKI-503-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:BAV0493
OrganismiBordetella avium (strain 197N)
Taxonomic identifieri360910 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
ProteomesiUP000001977: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 955955Glycine dehydrogenase (decarboxylating)PRO_1000045566Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei702 – 7021N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi360910.BAV0493.

Structurei

3D structure databases

ProteinModelPortaliQ2KYL7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiRAESEMT.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2KYL7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRALDTHSD FIPRHIGPSE ADQAKMLATI GCSSLDALLE EVVPPRIRNQ
60 70 80 90 100
APLALPGARS EPDVLAELKQ MAARNKVFRN YIGQGYYGTH TPNVVLRNVL
110 120 130 140 150
ENPAWYTAYT PYQPEISQGR LEALLNYQTM VADLTGLDIS NASLLDEGTA
160 170 180 190 200
AAEAMTLARR SAKSKSAVFF VSQHCHPQTI EVVRTRAQGL DIDVLVGDES
210 220 230 240 250
QGLPECFGVL LQYPHSLGGV VNYRELAEAA HAQGAVVACA TDLLALALLT
260 270 280 290 300
PPGEWGADIA VGTAQRFGVP FGFGGPHAGF MACRDAFKRN MPGRLVGVSK
310 320 330 340 350
DAQGNPALRL ALQTREQHIR REKATSNICT AQVLLAVMAG LYAVWHGPAG
360 370 380 390 400
LRRIATRVHT FAGVLRQHVQ ALGLTVENDS YFDTLLINTG PATPAVLRAA
410 420 430 440 450
ECAHINLRRV DAGRVAVSID ETVTVEDLQA LINVFAAGLG KDDITLDAAT
460 470 480 490 500
LAPEAGLPAG TVRTSPILSH PVFSSVQSET DMLRYLRKLA DKDLALDRSM
510 520 530 540 550
IPLGSCTMKL NATAEMIPIT WPEFALIHPF APADQTAGYR ELIERLSAAL
560 570 580 590 600
CEITGYDNIS LQPNSGAQGE YAGLLAIRGY HQARGEHQRN ICLIPSSAHG
610 620 630 640 650
TNPASAQLAG MDVVVVASDD HGNVDLDDLR AKIEQVGDRL AALMITYPST
660 670 680 690 700
HGVFEETVTE ICERVHAAGG QVYLDGANMN AMVGVAKPGK FGSDVSHLNL
710 720 730 740 750
HKTFCIPHGG GGPGVGPVAV RAHLAPYLPG VLNEQGKLDA EAKVGPVSAA
760 770 780 790 800
PYGSAGILAI PFVYISLMGA EGLRRATEVA ILNANYVATR LREYYPVLYA
810 820 830 840 850
GRHGRVAHEC ILDIRPLKES IGISAEDIAK RLMDYGFHAP TMSFPVAGTL
860 870 880 890 900
MVEPTESEGL AELERFIDAM IAIRAEVAQV ERGERDREDN VLKNAPHTAQ
910 920 930 940 950
MLLAEEWHHA YPRQQAAYPL ASLRDGKYWP PVARVDNAYG DRNLVCSCLP

IEAYI
Length:955
Mass (Da):102,819
Last modified:March 7, 2006 - v1
Checksum:i93E0C5A398CC62FD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM167904 Genomic DNA. Translation: CAJ48098.1.
RefSeqiWP_012416189.1. NC_010645.1.
YP_785026.1. NC_010645.1.

Genome annotation databases

EnsemblBacteriaiCAJ48098; CAJ48098; BAV0493.
GeneIDi6267060.
KEGGibav:BAV0493.
PATRICi21127136. VBIBorAvi43433_0504.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM167904 Genomic DNA. Translation: CAJ48098.1.
RefSeqiWP_012416189.1. NC_010645.1.
YP_785026.1. NC_010645.1.

3D structure databases

ProteinModelPortaliQ2KYL7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi360910.BAV0493.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ48098; CAJ48098; BAV0493.
GeneIDi6267060.
KEGGibav:BAV0493.
PATRICi21127136. VBIBorAvi43433_0504.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiRAESEMT.
OrthoDBiEOG6HMXDX.

Enzyme and pathway databases

BioCyciBAVI360910:GCKI-503-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Comparison of the genome sequence of the poultry pathogen Bordetella avium with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals extensive diversity in surface structures associated with host interaction."
    Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D., King N.D., Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D., Goble A., Lord A., Murphy L., Quail M.A., Rutter S., Squares R., Squares S., Woodward J., Parkhill J., Temple L.M.
    J. Bacteriol. 188:6002-6015(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 197N.

Entry informationi

Entry nameiGCSP_BORA1
AccessioniPrimary (citable) accession number: Q2KYL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 7, 2006
Last modified: February 4, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.