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Q2KYL7 (GCSP_BORA1) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:BAV0493
OrganismBordetella avium (strain 197N) [Complete proteome] [HAMAP]
Taxonomic identifier360910 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella

Protein attributes

Sequence length955 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 955955Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000045566

Amino acid modifications

Modified residue7021N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2KYL7 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: 93E0C5A398CC62FD

FASTA955102,819
        10         20         30         40         50         60 
MSRALDTHSD FIPRHIGPSE ADQAKMLATI GCSSLDALLE EVVPPRIRNQ APLALPGARS 

        70         80         90        100        110        120 
EPDVLAELKQ MAARNKVFRN YIGQGYYGTH TPNVVLRNVL ENPAWYTAYT PYQPEISQGR 

       130        140        150        160        170        180 
LEALLNYQTM VADLTGLDIS NASLLDEGTA AAEAMTLARR SAKSKSAVFF VSQHCHPQTI 

       190        200        210        220        230        240 
EVVRTRAQGL DIDVLVGDES QGLPECFGVL LQYPHSLGGV VNYRELAEAA HAQGAVVACA 

       250        260        270        280        290        300 
TDLLALALLT PPGEWGADIA VGTAQRFGVP FGFGGPHAGF MACRDAFKRN MPGRLVGVSK 

       310        320        330        340        350        360 
DAQGNPALRL ALQTREQHIR REKATSNICT AQVLLAVMAG LYAVWHGPAG LRRIATRVHT 

       370        380        390        400        410        420 
FAGVLRQHVQ ALGLTVENDS YFDTLLINTG PATPAVLRAA ECAHINLRRV DAGRVAVSID 

       430        440        450        460        470        480 
ETVTVEDLQA LINVFAAGLG KDDITLDAAT LAPEAGLPAG TVRTSPILSH PVFSSVQSET 

       490        500        510        520        530        540 
DMLRYLRKLA DKDLALDRSM IPLGSCTMKL NATAEMIPIT WPEFALIHPF APADQTAGYR 

       550        560        570        580        590        600 
ELIERLSAAL CEITGYDNIS LQPNSGAQGE YAGLLAIRGY HQARGEHQRN ICLIPSSAHG 

       610        620        630        640        650        660 
TNPASAQLAG MDVVVVASDD HGNVDLDDLR AKIEQVGDRL AALMITYPST HGVFEETVTE 

       670        680        690        700        710        720 
ICERVHAAGG QVYLDGANMN AMVGVAKPGK FGSDVSHLNL HKTFCIPHGG GGPGVGPVAV 

       730        740        750        760        770        780 
RAHLAPYLPG VLNEQGKLDA EAKVGPVSAA PYGSAGILAI PFVYISLMGA EGLRRATEVA 

       790        800        810        820        830        840 
ILNANYVATR LREYYPVLYA GRHGRVAHEC ILDIRPLKES IGISAEDIAK RLMDYGFHAP 

       850        860        870        880        890        900 
TMSFPVAGTL MVEPTESEGL AELERFIDAM IAIRAEVAQV ERGERDREDN VLKNAPHTAQ 

       910        920        930        940        950 
MLLAEEWHHA YPRQQAAYPL ASLRDGKYWP PVARVDNAYG DRNLVCSCLP IEAYI 

« Hide

References

[1]"Comparison of the genome sequence of the poultry pathogen Bordetella avium with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals extensive diversity in surface structures associated with host interaction."
Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D., King N.D., Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D., Goble A., Lord A., Murphy L., Quail M.A., Rutter S., Squares R., Squares S., Woodward J., Parkhill J., Temple L.M.
J. Bacteriol. 188:6002-6015(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 197N.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM167904 Genomic DNA. Translation: CAJ48098.1.
RefSeqYP_785026.1. NC_010645.1.

3D structure databases

ProteinModelPortalQ2KYL7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING360910.BAV0493.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6267060.
KEGGbav:BAV0493.
PATRIC21127136. VBIBorAvi43433_0504.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMATAYLTHP.
OrthoDBEOG6HMXDX.

Enzyme and pathway databases

BioCycBAVI360910:GCKI-503-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_BORA1
AccessionPrimary (citable) accession number: Q2KYL7
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 7, 2006
Last modified: May 14, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families