ID   HGD_BORA1               Reviewed;         432 AA.
AC   Q2KYC8;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   05-MAY-2009, entry version 21.
DE   RecName: Full=Homogentisate 1,2-dioxygenase;
DE            EC=1.13.11.5;
DE   AltName: Full=Homogentisicase;
DE   AltName: Full=Homogentisate oxygenase;
DE   AltName: Full=Homogentisic acid oxidase;
GN   Name=hmgA; OrderedLocusNames=BAV0528;
OS   Bordetella avium (strain 197N).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Bordetella.
OX   NCBI_TaxID=360910;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16885469; DOI=10.1128/JB.01927-05;
RA   Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D.,
RA   King N.D., Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D.,
RA   Goble A., Lord A., Murphy L., Quail M.A., Rutter S., Squares R.,
RA   Squares S., Woodward J., Parkhill J., Temple L.M.;
RT   "Comparison of the genome sequence of the poultry pathogen Bordetella
RT   avium with those of B. bronchiseptica, B. pertussis, and B.
RT   parapertussis reveals extensive diversity in surface structures
RT   associated with host interaction.";
RL   J. Bacteriol. 188:6002-6015(2006).
CC   -!- CATALYTIC ACTIVITY: Homogentisate + O(2) = 4-maleylacetoacetate.
CC   -!- COFACTOR: Iron (By similarity).
CC   -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation;
CC       acetoacetic acid and fumarate from L-phenylalanine: step 4/6.
CC   -!- SIMILARITY: Belongs to the homogentisate dioxygenase family.
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DR   EMBL; AM167904; CAJ48133.1; -; Genomic_DNA.
DR   RefSeq; YP_785061.1; -.
DR   GeneID; 6266951; -.
DR   GenomeReviews; AM167904_GR; BAV0528.
DR   KEGG; bav:BAV0528; -.
DR   NMPDR; fig|521.1.peg.1029; -.
DR   HOGENOM; Q2KYC8; -.
DR   OMA; Q2KYC8; HRNCMSE.
DR   GO; GO:0004411; F:homogentisate 1,2-dioxygenase activity; IEA:HAMAP.
DR   GO; GO:0005506; F:iron ion binding; IEA:HAMAP.
DR   GO; GO:0006559; P:L-phenylalanine catabolic process; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006572; P:tyrosine catabolic process; IEA:HAMAP.
DR   HAMAP; MF_00334; -; 1.
DR   InterPro; IPR005708; Homogentis_dOase.
DR   PANTHER; PTHR11056; Homogentis_dOase; 1.
DR   Pfam; PF04209; HgmA; 1.
DR   TIGRFAMs; TIGR01015; hmgA; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Dioxygenase; Iron; Metal-binding; Oxidoreductase;
KW   Phenylalanine catabolism; Tyrosine catabolism.
FT   CHAIN         1    432       Homogentisate 1,2-dioxygenase.
FT                                /FTId=PRO_1000019520.
FT   METAL       329    329       Iron (By similarity).
FT   METAL       335    335       Iron (By similarity).
FT   METAL       365    365       Iron (By similarity).
SQ   SEQUENCE   432 AA;  47808 MW;  2CEC82ACE2DE950E CRC64;
     MPLNYQSGFG NACATEALPG ALPQGRNSPQ QCPYGLYAEQ LSGTAFTAPR SENRRSWLYR
     IRPGVVHRPF EPYAGAPHWL ADFGTGPVTP NQLRWSPLPL PATPTDFIDG VHTWGGNGGP
     DEQSGVGIHL YAANQSMKGR FFYNADAEML LVPQLGRLRL ATEMGLLDLE PLEIAVLPRG
     VRFRVELLDA EARGYLLENF GTALRPPELG PIGSNGLANA RDFQTPVAWY EDVEGDFELI
     AKFTGGFWRA PLTHSPLDVV AWHGTHAPYK YDLRHFNTIG SISYDHPDPS IFTVLTSPSD
     TPGTANLDFA IFPPRILAME NTFRPPWFHR NIASEFMGLI QGVYDAKAEG FAPGGASLHN
     CMSGHGPDAD TFEKASVADT SKAHYIRDTM AFMFETRRVI RPTRQALASA QLQGDYYQCW
     QDLKKHFNPE KA
//