Q2KYC8 (HGD_BORA1) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 29, 2013.
Version 50.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Homogentisate 1,2-dioxygenase EC=1.13.11.5 Alternative name(s): Homogentisate oxygenase Homogentisic acid oxidase Homogentisicase | ||||
| Gene names |
| ||||
| Organism | Bordetella avium (strain 197N) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 360910 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella › ![]() |
Protein attributes
| Sequence length | 432 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | Homogentisate + O2 = 4-maleylacetoacetate. HAMAP-Rule MF_00334 |
| Cofactor | Iron By similarity. HAMAP-Rule MF_00334 |
| Pathway | Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6. HAMAP-Rule MF_00334 |
| Sequence similarities | Belongs to the homogentisate dioxygenase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Phenylalanine catabolism Tyrosine catabolism |
| Ligand | Iron Metal-binding |
| Molecular function | Dioxygenase Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological_process | L-phenylalanine catabolic process Inferred from electronic annotation. Source: HAMAP tyrosine catabolic processInferred from electronic annotation. Source: HAMAP |
| Molecular_function | homogentisate 1,2-dioxygenase activity Inferred from electronic annotation. Source: HAMAP iron ion bindingInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 432 | 432 | Homogentisate 1,2-dioxygenase HAMAP-Rule MF_00334 | PRO_1000019520 | |||||
Sites | |||||||||
| Metal binding | 329 | 1 | Iron By similarity | ||||||
| Metal binding | 335 | 1 | Iron By similarity | ||||||
| Metal binding | 365 | 1 | Iron By similarity | ||||||
Sequences
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References
| [1] | "Comparison of the genome sequence of the poultry pathogen Bordetella avium with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals extensive diversity in surface structures associated with host interaction." Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D., King N.D., Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D., Goble A., Lord A., Murphy L., Quail M.A., Rutter S., Squares R., Squares S., Woodward J., Parkhill J., Temple L.M. J. Bacteriol. 188:6002-6015(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 197N. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AM167904 Genomic DNA. Translation: CAJ48133.1. |
| RefSeq | YP_785061.1. NC_010645.1. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 360910.BAV0528. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 6266951. |
| KEGG | bav:BAV0528. |
| PATRIC | 21127210. VBIBorAvi43433_0541. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG3508. |
| HOGENOM | HOG000139824. |
| KO | K00451. |
| OMA | AVTKWGL. |
| ProtClustDB | PRK05341. |
Enzyme and pathway databases | |
| BioCyc | BAVI360910:GCKI-538-MONOMER. |
| UniPathway | UPA00139; UER00339. |
Family and domain databases | |
| Gene3D | 2.60.120.10. 2 hits. |
| HAMAP | MF_00334. Homogentis_dioxygen. |
| InterPro | IPR005708. Homogentis_dOase. IPR022950. Homogentis_dOase_bac. IPR014710. RmlC-like_jellyroll. IPR011051. RmlC_Cupin. [Graphical view] |
| PANTHER | PTHR11056. PTHR11056. 1 hit. |
| Pfam | PF04209. HgmA. 1 hit. [Graphical view] |
| SUPFAM | SSF51182. RmlC_like_cupin. 1 hit. |
| TIGRFAMs | TIGR01015. hmgA. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | HGD_BORA1 | ||||||||
| Accession | Primary (citable) accession number: Q2KYC8 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with
