Reviewed, UniProtKB/Swiss-Prot Q2KYC8 (HGD_BORA1)

Names and origin

Protein names

Recommended name:
    Homogentisate 1,2-dioxygenase
    EC=1.13.11.5
Alternative name(s):
    Homogentisicase
    Homogentisate oxygenase
    Homogentisic acid oxidase

Gene names

Name:	hmgA
Ordered Locus Names:	BAV0528

Organism

Bordetella avium (strain 197N) [Complete proteome] [HAMAP]

Taxonomic identifier

360910 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	432 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Homogentisate + O(2) = 4-maleylacetoacetate.
Cofactor	Iron By similarity.
Pathway	Amino-acid degradation; L-phenylalanine degradation; acetoacetic acid and fumarate from L-phenylalanine: step 4/6.
Sequence similarities	Belongs to the homogentisate dioxygenase family.

Ontologies

Keywords
Biological process	Phenylalanine catabolism Tyrosine catabolism
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	L-phenylalanine catabolic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tyrosine catabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	homogentisate 1,2-dioxygenase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 432	432	Homogentisate 1,2-dioxygenase		PRO_1000019520
Sites
	Metal binding	329	1	Iron By similarity
	Metal binding	335	1	Iron By similarity
	Metal binding	365	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2KYC8-1 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 2CEC82ACE2DE950E	FASTA	432	47,808
	10 20 30 40 50 60 MPLNYQSGFG NACATEALPG ALPQGRNSPQ QCPYGLYAEQ LSGTAFTAPR SENRRSWLYR 70 80 90 100 110 120 IRPGVVHRPF EPYAGAPHWL ADFGTGPVTP NQLRWSPLPL PATPTDFIDG VHTWGGNGGP 130 140 150 160 170 180 DEQSGVGIHL YAANQSMKGR FFYNADAEML LVPQLGRLRL ATEMGLLDLE PLEIAVLPRG 190 200 210 220 230 240 VRFRVELLDA EARGYLLENF GTALRPPELG PIGSNGLANA RDFQTPVAWY EDVEGDFELI 250 260 270 280 290 300 AKFTGGFWRA PLTHSPLDVV AWHGTHAPYK YDLRHFNTIG SISYDHPDPS IFTVLTSPSD 310 320 330 340 350 360 TPGTANLDFA IFPPRILAME NTFRPPWFHR NIASEFMGLI QGVYDAKAEG FAPGGASLHN 370 380 390 400 410 420 CMSGHGPDAD TFEKASVADT SKAHYIRDTM AFMFETRRVI RPTRQALASA QLQGDYYQCW 430 QDLKKHFNPE KA

References

[1]

"Comparison of the genome sequence of the poultry pathogen Bordetella avium with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals extensive diversity in surface structures associated with host interaction." Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D., King N.D., Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D., Goble A., Lord A., Murphy L., Quail M.A., Rutter S., Squares R., Squares S., Woodward J., Parkhill J., Temple L.M. J. Bacteriol. 188:6002-6015(2006) [PubMed: 16885469] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM167904 Genomic DNA. Translation: CAJ48133.1.
RefSeq	YP_785061.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6266951.
GenomeReviews	Gene locus BAV0528 in contig AM167904_GR.
KEGG	bav:BAV0528.
NMPDR	fig|521.1.peg.1029.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2KYC8.
Family and domain databases
HAMAP	MF_00334. [Tree]
InterPro	IPR005708. Homogentis_dOase. [Graphical view]
PANTHER	PTHR11056. Homogentis_dOase. 1 hit.
Pfam	PF04209. HgmA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01015. hmgA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HGD_BORA1

Accession

Primary (citable) accession number: Q2KYC8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	March 7, 2006
Last modified:	November 4, 2008
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)