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Q2KXU8

- ACDH_BORA1

UniProt

Q2KXU8 - ACDH_BORA1

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Protein
Acetaldehyde dehydrogenase
Gene
bphG, BAV0599
Organism
Bordetella avium (strain 197N)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei132 – 1321Acyl-thioester intermediate By similarity
Binding sitei289 – 2891NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 154NAD By similarity
Nucleotide bindingi163 – 1719NAD By similarity

GO - Molecular functioni

  1. NAD binding Source: UniProtKB-HAMAP
  2. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciBAVI360910:GCKI-610-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase (EC:1.2.1.10)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]
Gene namesi
Name:bphG
Ordered Locus Names:BAV0599
OrganismiBordetella avium (strain 197N)
Taxonomic identifieri360910 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
ProteomesiUP000001977: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316Acetaldehyde dehydrogenaseUniRule annotation
PRO_1000187027Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi360910.BAV0599.

Structurei

3D structure databases

ProteinModelPortaliQ2KXU8.
SMRiQ2KXU8. Positions 1-309.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4569.
HOGENOMiHOG000052149.
KOiK04073.
OMAiSIYLEIE.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2KXU8-1 [UniParc]FASTAAdd to Basket

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MTRRLKAAII GSGNIGTDLM IKILRHGKHI DMAAMVGIDP KSDGLARAAR    50
LGVATTYEGV AGLIRLPVFA DIDFVFDATS AGAHVENDAL LRAAKPGIRL 100
VDLTPAAIGP YCIPVVNGDA HLDALNVNMV TCGGQATIPM VAAVSRVARV 150
HYAEIVASIA SKSAGPGTRA NIDEFTETTA KAIEAVGGAT KGKAIIVMNP 200
AEPPLIMRDT VYTLSQPADE EAIAESVERM VAAVQAYVPG YRLKQKVQFD 250
RIDSPLRIPG VGDALKGLKT SIFLEVEGAA HYLPAYAGNL DIMTSAALRT 300
AEHMAQRMLA DATVSA 316
Length:316
Mass (Da):33,179
Last modified:March 7, 2006 - v1
Checksum:i1924243FC0DFCFA2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM167904 Genomic DNA. Translation: CAJ48204.1.
RefSeqiWP_012416294.1. NC_010645.1.
YP_785131.1. NC_010645.1.

Genome annotation databases

GeneIDi6266727.
KEGGibav:BAV0599.
PATRICi21127356. VBIBorAvi43433_0613.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM167904 Genomic DNA. Translation: CAJ48204.1 .
RefSeqi WP_012416294.1. NC_010645.1.
YP_785131.1. NC_010645.1.

3D structure databases

ProteinModelPortali Q2KXU8.
SMRi Q2KXU8. Positions 1-309.
ModBasei Search...

Protein-protein interaction databases

STRINGi 360910.BAV0599.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 6266727.
KEGGi bav:BAV0599.
PATRICi 21127356. VBIBorAvi43433_0613.

Phylogenomic databases

eggNOGi COG4569.
HOGENOMi HOG000052149.
KOi K04073.
OMAi SIYLEIE.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci BAVI360910:GCKI-610-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Comparison of the genome sequence of the poultry pathogen Bordetella avium with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals extensive diversity in surface structures associated with host interaction."
    Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D., King N.D., Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D., Goble A., Lord A., Murphy L., Quail M.A., Rutter S., Squares R., Squares S., Woodward J., Parkhill J., Temple L.M.
    J. Bacteriol. 188:6002-6015(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 197N.

Entry informationi

Entry nameiACDH_BORA1
AccessioniPrimary (citable) accession number: Q2KXU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: March 7, 2006
Last modified: September 3, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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