Q2KXU8 (ACDH_BORA1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetaldehyde dehydrogenase
EC=1.2.1.10

Alternative name(s):
Acetaldehyde dehydrogenase [acetylating]

Gene names

Name:	bphG
Ordered Locus Names:	BAV0599

Organism

Bordetella avium (strain 197N) [Complete proteome] [HAMAP]

Taxonomic identifier

360910 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	316 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity. HAMAP MF_01657
Catalytic activity	Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH. HAMAP MF_01657
Sequence similarities	Belongs to the acetaldehyde dehydrogenase family.

Ontologies

Keywords
Biological process	Aromatic hydrocarbons catabolism
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic compound catabolic process Inferred from electronic annotation. Source: UniProtKB-KW cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	NAD binding Inferred from electronic annotation. Source: InterPro acetaldehyde dehydrogenase (acetylating) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 316	316	Acetaldehyde dehydrogenase HAMAP MF_01657		PRO_1000187027
Regions
	Nucleotide binding	12 – 15	4	NAD By similarity
	Nucleotide binding	163 – 171	9	NAD By similarity
Sites
	Binding site	289	1	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2KXU8 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 1924243FC0DFCFA2	FASTA	316	33,179
	10 20 30 40 50 60 MTRRLKAAII GSGNIGTDLM IKILRHGKHI DMAAMVGIDP KSDGLARAAR LGVATTYEGV 70 80 90 100 110 120 AGLIRLPVFA DIDFVFDATS AGAHVENDAL LRAAKPGIRL VDLTPAAIGP YCIPVVNGDA 130 140 150 160 170 180 HLDALNVNMV TCGGQATIPM VAAVSRVARV HYAEIVASIA SKSAGPGTRA NIDEFTETTA 190 200 210 220 230 240 KAIEAVGGAT KGKAIIVMNP AEPPLIMRDT VYTLSQPADE EAIAESVERM VAAVQAYVPG 250 260 270 280 290 300 YRLKQKVQFD RIDSPLRIPG VGDALKGLKT SIFLEVEGAA HYLPAYAGNL DIMTSAALRT 310 AEHMAQRMLA DATVSA

References

[1]

"Comparison of the genome sequence of the poultry pathogen Bordetella avium with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals extensive diversity in surface structures associated with host interaction." Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D., King N.D., Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D., Goble A., Lord A., Murphy L., Quail M.A., Rutter S., Squares R., Squares S., Woodward J., Parkhill J., Temple L.M. J. Bacteriol. 188:6002-6015(2006) [PubMed: 16885469] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 197N.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM167904 Genomic DNA. Translation: CAJ48204.1.
RefSeq	YP_785131.1. NC_010645.1.
3D structure databases
ProteinModelPortal	Q2KXU8.
SMR	Q2KXU8. Positions 1-309.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2KXU8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6266727.
GenomeReviews	Gene locus BAV0599 in contig AM167904_GR.
KEGG	bav:BAV0599.
NMPDR	fig|521.1.peg.2589.
PATRIC	21127356. VBIBorAvi43433_0613.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG300125.
OMA	HVKNDAF.
ProtClustDB	PRK08300.
Enzyme and pathway databases
BioCyc	ABAU360910:BAV0599-MONOMER.
Family and domain databases
HAMAP	MF_01657. Ac_ald_DH_ac. [Tree]
InterPro	IPR003361. Acetaldehyde_dehydrogenase. IPR015426. Acetylaldehyde_DH_C. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K04073.
PANTHER	PTHR21123. Acetylald_dh. 1 hit.
Pfam	PF09290. AcetDehyd-dimer. 1 hit. PF01118. Semialdhyde_dh. 1 hit. [Graphical view]
PIRSF	PIRSF015689. Actaldh_dh_actl. 1 hit.
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR03215. Ac_ald_DH_ac. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ACDH_BORA1

Accession

Primary (citable) accession number: Q2KXU8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	March 7, 2006
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program