Reviewed, UniProtKB/Swiss-Prot Q2KXU7 (ALR_BORA1)

Names and origin

Protein names

Recommended name:
    Alanine racemase
    EC=5.1.1.1

Gene names

Name:	alr
Ordered Locus Names:	BAV2416

Organism

Bordetella avium (strain 197N) [Complete proteome] [HAMAP]

Taxonomic identifier

360910 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	374 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Provides the D-alanine required for cell wall biosynthesis By similarity.
Catalytic activity	L-alanine = D-alanine. HAMAP MF_01201
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP MF_01201 Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_01201
Sequence similarities	Belongs to the alanine racemase family.

Ontologies

Keywords
Biological process	Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Ligand	Pyridoxal phosphate
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	alanine metabolic process Inferred from electronic annotation. Source: HAMAP cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alanine racemase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 374	374	Alanine racemase HAMAP MF_01201		PRO_1000065971
Sites
	Active site	44	1	Proton acceptor; specific for D-alanine By similarity
	Active site	269	1	Proton acceptor; specific for L-alanine By similarity
Amino acid modifications
	Modified residue	44	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2KXU7-1 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 94E4487AA5D789F2	FASTA	374	39,188
	10 20 30 40 50 60 MPRPIFALIS PTALRHNLSV VRQHLNRAAV AAGGVPPSIW AVIKANAYGH GIERALRAFS 70 80 90 100 110 120 EAQGLAMLDI EEAVRCREAG WAGPILLLEG FFTPQDIDLL DRYHISTAVH CQEQLDMLAR 130 140 150 160 170 180 ARPSHRINAM VKLNSGMNRL GFSPQAYGAA FEAAQALMRD GVLGSVGKMT HFATADGPQG 190 200 210 220 230 240 PQWQWEVFQA ATQGLPGPVS VCNSAATLRY PELAAGPGAT HWVRPGICLY GASPFSDTPA 250 260 270 280 290 300 AAFGLRPAMT LRAEIIGVQQ VSPGQTVGYG ATFAASKAMR VGVVSCGYAD GYPRHCATGT 310 320 330 340 350 360 PVTVNGVATR LLGRVSMDMM MVDLDPVPAA GVGAPVVLWG EGGPDVDAVA AAGGTIGYEL 370 LTALAARVPV RDAS

References

[1]

"Comparison of the genome sequence of the poultry pathogen Bordetella avium with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals extensive diversity in surface structures associated with host interaction." Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D., King N.D., Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D., Goble A., Lord A., Murphy L., Quail M.A., Rutter S., Squares R., Squares S., Woodward J., Parkhill J., Temple L.M. J. Bacteriol. 188:6002-6015(2006) [PubMed: 16885469] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM167904 Genomic DNA. Translation: CAJ50026.1.
RefSeq	YP_786930.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6265961.
GenomeReviews	Gene locus BAV2416 in contig AM167904_GR.
KEGG	bav:BAV2416.
NMPDR	fig|521.1.peg.60.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2KXU7.
OMA	Q2KXU7. TGLKPAM.
Family and domain databases
HAMAP	MF_01201. [Tree]
InterPro	IPR011079. Ala_racemase_C. IPR001608. Ala_racemase_N. IPR000821. Ala_racemase_reg. [Graphical view]
Pfam	PF00842. Ala_racemase_C. 1 hit. PF01168. Ala_racemase_N. 1 hit. [Graphical view]
PRINTS	PR00992. ALARACEMASE.
TIGRFAMs	TIGR00492. alr. 1 hit.
PROSITE	PS00395. ALANINE_RACEMASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALR_BORA1

Accession

Primary (citable) accession number: Q2KXU7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	March 7, 2006
Last modified:	June 16, 2009
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)