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Q2KXM7 (NAGZ_BORA1) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-hexosaminidase

EC=3.2.1.52
Alternative name(s):
Beta-N-acetylhexosaminidase
N-acetyl-beta-glucosaminidase
Gene names
Name:nagZ
Ordered Locus Names:BAV2457
OrganismBordetella avium (strain 197N) [Complete proteome] [HAMAP]
Taxonomic identifier360910 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella

Protein attributes

Sequence length350 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides By similarity. HAMAP-Rule MF_00364

Catalytic activity

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. HAMAP-Rule MF_00364

Pathway

Cell wall biogenesis; peptidoglycan recycling. HAMAP-Rule MF_00364

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00364.

Sequence similarities

Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 350350Beta-hexosaminidase HAMAP-Rule MF_00364
PRO_0000234911

Regions

Region178 – 1792Substrate binding By similarity

Sites

Active site1911Proton donor/acceptor By similarity
Active site2621Nucleophile By similarity
Binding site731Substrate By similarity
Binding site811Substrate By similarity
Binding site1481Substrate By similarity
Site1891Important for catalytic activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2KXM7 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: B1C6C79C9EFDA96B

FASTA35038,078
        10         20         30         40         50         60 
MSKSRKPSLL PPGPVMVDVA GGQLTEQEKQ RLRHPLVGGV ILFARNFENR AQLTALTQDI 

        70         80         90        100        110        120 
HAARGEPLLI AVDHEGGRVQ RFREDGFTAL PAMRTLGEVW DRDPLAAMQL ATQTGYVLAA 

       130        140        150        160        170        180 
ELRACGVDMS FTPVLDLDYG VSKVIGNRAF HADPRVVAML ARALVQGLAL TGMAACGKHF 

       190        200        210        220        230        240 
PGHGYVEADS HHEIPVDTRT LADILKDDAA PYGWLGDQIL PSVMPAHVIY PEVDSQPAGF 

       250        260        270        280        290        300 
SRRWVSEILR GQLGYDGVVF SDDLTMEGAS VAGDILARAQ AALSAGCDMV LVCNRPDLAD 

       310        320        330        340        350 
DLLERLSFTP PAVDRIRRLM PAYAAPDWDS LQADSRYQHA RRIQSQIISG 

« Hide

References

[1]"Comparison of the genome sequence of the poultry pathogen Bordetella avium with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals extensive diversity in surface structures associated with host interaction."
Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D., King N.D., Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D., Goble A., Lord A., Murphy L., Quail M.A., Rutter S., Squares R., Squares S., Woodward J., Parkhill J., Temple L.M.
J. Bacteriol. 188:6002-6015(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 197N.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM167904 Genomic DNA. Translation: CAJ50067.1.
RefSeqYP_786969.1. NC_010645.1.

3D structure databases

ProteinModelPortalQ2KXM7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING360910.BAV2457.

Protein family/group databases

CAZyGH3. Glycoside Hydrolase Family 3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6267924.
KEGGbav:BAV2457.
PATRIC21131161. VBIBorAvi43433_2485.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1472.
HOGENOMHOG000248526.
KOK01207.
OMAAGFSSYW.
OrthoDBEOG6BCT06.
ProtClustDBPRK05337.

Enzyme and pathway databases

BioCycBAVI360910:GCKI-2504-MONOMER.
UniPathwayUPA00544.

Family and domain databases

Gene3D3.20.20.300. 1 hit.
HAMAPMF_00364. NagZ.
InterProIPR022956. Beta_hexosaminidase_bac.
IPR019800. Glyco_hydro_3_AS.
IPR001764. Glyco_hydro_3_N.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamPF00933. Glyco_hydro_3. 1 hit.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
PROSITEPS00775. GLYCOSYL_HYDROL_F3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNAGZ_BORA1
AccessionPrimary (citable) accession number: Q2KXM7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: March 7, 2006
Last modified: April 16, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries