Q2KXM7 (NAGZ_BORA1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Beta-hexosaminidase
EC=3.2.1.52

Alternative name(s):
Beta-N-acetylhexosaminidase
N-acetyl-beta-glucosaminidase

Gene names

Name:	nagZ
Ordered Locus Names:	BAV2457

Organism

Bordetella avium (strain 197N) [Complete proteome] [HAMAP]

Taxonomic identifier

360910 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	350 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides By similarity. HAMAP MF_00364
Catalytic activity	Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. HAMAP MF_00364
Pathway	Cell wall biogenesis; peptidoglycan recycling. HAMAP MF_00364
Subcellular location	Cytoplasm By similarity HAMAP MF_00364.
Sequence similarities	Belongs to the glycosyl hydrolase 3 family. NagZ subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cytoplasm
Molecular function	Glycosidase Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	beta-N-acetylhexosaminidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 350	350	Beta-hexosaminidase HAMAP MF_00364		PRO_0000234911
Sites
	Active site	262	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2KXM7 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: B1C6C79C9EFDA96B	FASTA	350	38,078
	10 20 30 40 50 60 MSKSRKPSLL PPGPVMVDVA GGQLTEQEKQ RLRHPLVGGV ILFARNFENR AQLTALTQDI 70 80 90 100 110 120 HAARGEPLLI AVDHEGGRVQ RFREDGFTAL PAMRTLGEVW DRDPLAAMQL ATQTGYVLAA 130 140 150 160 170 180 ELRACGVDMS FTPVLDLDYG VSKVIGNRAF HADPRVVAML ARALVQGLAL TGMAACGKHF 190 200 210 220 230 240 PGHGYVEADS HHEIPVDTRT LADILKDDAA PYGWLGDQIL PSVMPAHVIY PEVDSQPAGF 250 260 270 280 290 300 SRRWVSEILR GQLGYDGVVF SDDLTMEGAS VAGDILARAQ AALSAGCDMV LVCNRPDLAD 310 320 330 340 350 DLLERLSFTP PAVDRIRRLM PAYAAPDWDS LQADSRYQHA RRIQSQIISG

References

[1]

"Comparison of the genome sequence of the poultry pathogen Bordetella avium with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals extensive diversity in surface structures associated with host interaction." Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D., King N.D., Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D., Goble A., Lord A., Murphy L., Quail M.A., Rutter S., Squares R., Squares S., Woodward J., Parkhill J., Temple L.M. J. Bacteriol. 188:6002-6015(2006) [PubMed: 16885469] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 197N.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM167904 Genomic DNA. Translation: CAJ50067.1.
RefSeq	YP_786969.1. NC_010645.1.
3D structure databases
ProteinModelPortal	Q2KXM7.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2KXM7.
Protein family/group databases
CAZy	GH3. Glycoside Hydrolase Family 3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6267924.
GenomeReviews	Gene locus BAV2457 in contig AM167904_GR.
KEGG	bav:BAV2457.
NMPDR	fig|521.1.peg.33.
PATRIC	21131161. VBIBorAvi43433_2485.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG617255.
OMA	DLTMEGA.
ProtClustDB	PRK05337.
Enzyme and pathway databases
BioCyc	ABAU360910:BAV2457-MONOMER.
Family and domain databases
HAMAP	MF_00364. NagZ. [Tree]
InterPro	IPR022956. Beta_hexosaminidase. IPR019800. Glyco_hydro_3_AS. IPR001764. Glyco_hydro_3_N. IPR017853. Glycoside_hydrolase_SF. [Graphical view]
Gene3D	G3DSA:3.20.20.300. Glyco_hydro_3_N. 1 hit.
KO	K01207.
Pfam	PF00933. Glyco_hydro_3. 1 hit. [Graphical view]
SUPFAM	SSF51445. Glyco_hydro_cat. 1 hit.
PROSITE	PS00775. GLYCOSYL_HYDROL_F3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NAGZ_BORA1

Accession

Primary (citable) accession number: Q2KXM7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	March 7, 2006
Last modified:	January 25, 2012
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program