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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Bordetella avium (strain 197N)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei642ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBAVI360910:GCKI-2513-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:BAV2492
OrganismiBordetella avium (strain 197N)
Taxonomic identifieri360910 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
Proteomesi
  • UP000001977 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000092981 – 885Leucine--tRNA ligaseAdd BLAST885

Interactioni

Protein-protein interaction databases

STRINGi360910.BAV2492.

Structurei

3D structure databases

ProteinModelPortaliQ2KXE5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi48 – 58"HIGH" regionAdd BLAST11
Motifi639 – 643"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T. Bacteria.
COG0495. LUCA.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHRFIKRL.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 4 hits.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2KXE5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQERYQPNLV EAAAQQDWQA RDAYLVHESA KNADGSEKPK FYACSMLPYP
60 70 80 90 100
SGKLHMGHVR NYTINDMMAR QLRMRGYNVL MPMGWDAFGM PAENAAIKSK
110 120 130 140 150
VPPAKWTYDN IAYMKKQMKA MGLAIDWSRE MCACDPAYYK WNQWLFLKML
160 170 180 190 200
EKGIAYRKTQ VVNWDPVDQT VLANEQVIDG RGWRSGAPVE KREIPGYYLR
210 220 230 240 250
ITDYADELLD QVKNGLPGWP ERVRVMQENW IGKSEGVRLA FPHDIKDENG
260 270 280 290 300
QLIQDGKLFV FTTRADTVMG VTFCAVAPEH PLATLAARNN PALATFIEQC
310 320 330 340 350
KLGGTTEAEI ATREKEGIPT GLSVKHPLTG QAVDLWVGNY VLMSYGDGAV
360 370 380 390 400
MGVPAHDERD FAFARKYGLT IRQVIAQEGK TYSDQAWQEW YGDKQTGRTI
410 420 430 440 450
NSGKYDGLST AEAVDAIAAD LNALGLGEKQ TTYRLRDWGI SRQRYWGTPI
460 470 480 490 500
PIIHCQDCGP VPVPEQDLPV VLPDDLIPDG SGNPLAKNEA FLSCSCPACG
510 520 530 540 550
KPARRETDTM DTFVDSSWYF MRYTSPGNDQ AMVDKRNDYW MPMDQYIGGI
560 570 580 590 600
EHAVLHLLYA RFWTKVMRDL GMLKFDEPFT RLLCQGMVLN HIYSRRTPQG
610 620 630 640 650
GIEYFWPEEV ENIYDAKGAI VGARLKSDGS EITYGGVGTM SKSKNNGVDP
660 670 680 690 700
QSLIDTLGAD TARLFVMFAS PPEQTLEWSD SGVDGANRFL RRLWALAYDR
710 720 730 740 750
RAAVARGLAS GYAWQDAPAP VKDLRRELYG LLKQAEYDYQ RIQYNTVVSA
760 770 780 790 800
SMKMLNAIDN AQLPEGPAAD AAIAEGLGLL LRVLYPVVPH VTWHIWRDLG
810 820 830 840 850
YAAELGDLLD APWPHVDEAA LIADEIELML QVNGKLRGAI RVAAQAAKED
860 870 880
IEKIAVAQEE VARFLEGRPP KRVIVVPGKL VNVVG
Length:885
Mass (Da):99,022
Last modified:March 7, 2006 - v1
Checksum:iA55D8D4B863156EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM167904 Genomic DNA. Translation: CAJ50102.1.
RefSeqiWP_012418149.1. NC_010645.1.

Genome annotation databases

EnsemblBacteriaiCAJ50102; CAJ50102; BAV2492.
KEGGibav:BAV2492.
PATRICi21131223. VBIBorAvi43433_2516.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM167904 Genomic DNA. Translation: CAJ50102.1.
RefSeqiWP_012418149.1. NC_010645.1.

3D structure databases

ProteinModelPortaliQ2KXE5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi360910.BAV2492.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ50102; CAJ50102; BAV2492.
KEGGibav:BAV2492.
PATRICi21131223. VBIBorAvi43433_2516.

Phylogenomic databases

eggNOGiENOG4105C8T. Bacteria.
COG0495. LUCA.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHRFIKRL.

Enzyme and pathway databases

BioCyciBAVI360910:GCKI-2513-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 4 hits.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYL_BORA1
AccessioniPrimary (citable) accession number: Q2KXE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 7, 2006
Last modified: November 2, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.