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Q2KXE5 (SYL_BORA1) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:BAV2492
OrganismBordetella avium (strain 197N) [Complete proteome] [HAMAP]
Taxonomic identifier360910 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella

Protein attributes

Sequence length885 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 885885Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_1000009298

Regions

Motif48 – 5811"HIGH" region HAMAP-Rule MF_00049
Motif639 – 6435"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6421ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q2KXE5 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: A55D8D4B863156EF

FASTA88599,022
        10         20         30         40         50         60 
MQERYQPNLV EAAAQQDWQA RDAYLVHESA KNADGSEKPK FYACSMLPYP SGKLHMGHVR 

        70         80         90        100        110        120 
NYTINDMMAR QLRMRGYNVL MPMGWDAFGM PAENAAIKSK VPPAKWTYDN IAYMKKQMKA 

       130        140        150        160        170        180 
MGLAIDWSRE MCACDPAYYK WNQWLFLKML EKGIAYRKTQ VVNWDPVDQT VLANEQVIDG 

       190        200        210        220        230        240 
RGWRSGAPVE KREIPGYYLR ITDYADELLD QVKNGLPGWP ERVRVMQENW IGKSEGVRLA 

       250        260        270        280        290        300 
FPHDIKDENG QLIQDGKLFV FTTRADTVMG VTFCAVAPEH PLATLAARNN PALATFIEQC 

       310        320        330        340        350        360 
KLGGTTEAEI ATREKEGIPT GLSVKHPLTG QAVDLWVGNY VLMSYGDGAV MGVPAHDERD 

       370        380        390        400        410        420 
FAFARKYGLT IRQVIAQEGK TYSDQAWQEW YGDKQTGRTI NSGKYDGLST AEAVDAIAAD 

       430        440        450        460        470        480 
LNALGLGEKQ TTYRLRDWGI SRQRYWGTPI PIIHCQDCGP VPVPEQDLPV VLPDDLIPDG 

       490        500        510        520        530        540 
SGNPLAKNEA FLSCSCPACG KPARRETDTM DTFVDSSWYF MRYTSPGNDQ AMVDKRNDYW 

       550        560        570        580        590        600 
MPMDQYIGGI EHAVLHLLYA RFWTKVMRDL GMLKFDEPFT RLLCQGMVLN HIYSRRTPQG 

       610        620        630        640        650        660 
GIEYFWPEEV ENIYDAKGAI VGARLKSDGS EITYGGVGTM SKSKNNGVDP QSLIDTLGAD 

       670        680        690        700        710        720 
TARLFVMFAS PPEQTLEWSD SGVDGANRFL RRLWALAYDR RAAVARGLAS GYAWQDAPAP 

       730        740        750        760        770        780 
VKDLRRELYG LLKQAEYDYQ RIQYNTVVSA SMKMLNAIDN AQLPEGPAAD AAIAEGLGLL 

       790        800        810        820        830        840 
LRVLYPVVPH VTWHIWRDLG YAAELGDLLD APWPHVDEAA LIADEIELML QVNGKLRGAI 

       850        860        870        880 
RVAAQAAKED IEKIAVAQEE VARFLEGRPP KRVIVVPGKL VNVVG 

« Hide

References

[1]"Comparison of the genome sequence of the poultry pathogen Bordetella avium with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals extensive diversity in surface structures associated with host interaction."
Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D., King N.D., Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D., Goble A., Lord A., Murphy L., Quail M.A., Rutter S., Squares R., Squares S., Woodward J., Parkhill J., Temple L.M.
J. Bacteriol. 188:6002-6015(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 197N.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM167904 Genomic DNA. Translation: CAJ50102.1.
RefSeqYP_787004.1. NC_010645.1.

3D structure databases

ProteinModelPortalQ2KXE5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING360910.BAV2492.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6266007.
KEGGbav:BAV2492.
PATRIC21131223. VBIBorAvi43433_2516.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200747.
KOK01869.
OMAPVIHCPK.
OrthoDBEOG63Z74X.

Enzyme and pathway databases

BioCycBAVI360910:GCKI-2539-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_BORA1
AccessionPrimary (citable) accession number: Q2KXE5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 7, 2006
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries