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Q2KXE5

- SYL_BORA1

UniProt

Q2KXE5 - SYL_BORA1

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Protein
Leucine--tRNA ligase
Gene
leuS, BAV2492
Organism
Bordetella avium (strain 197N)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei642 – 6421ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBAVI360910:GCKI-2539-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:BAV2492
OrganismiBordetella avium (strain 197N)
Taxonomic identifieri360910 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
ProteomesiUP000001977: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 885885Leucine--tRNA ligaseUniRule annotation
PRO_1000009298Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi360910.BAV2492.

Structurei

3D structure databases

ProteinModelPortaliQ2KXE5.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi48 – 5811"HIGH" regionUniRule annotation
Add
BLAST
Motifi639 – 6435"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiPVIHCPK.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2KXE5-1 [UniParc]FASTAAdd to Basket

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MQERYQPNLV EAAAQQDWQA RDAYLVHESA KNADGSEKPK FYACSMLPYP    50
SGKLHMGHVR NYTINDMMAR QLRMRGYNVL MPMGWDAFGM PAENAAIKSK 100
VPPAKWTYDN IAYMKKQMKA MGLAIDWSRE MCACDPAYYK WNQWLFLKML 150
EKGIAYRKTQ VVNWDPVDQT VLANEQVIDG RGWRSGAPVE KREIPGYYLR 200
ITDYADELLD QVKNGLPGWP ERVRVMQENW IGKSEGVRLA FPHDIKDENG 250
QLIQDGKLFV FTTRADTVMG VTFCAVAPEH PLATLAARNN PALATFIEQC 300
KLGGTTEAEI ATREKEGIPT GLSVKHPLTG QAVDLWVGNY VLMSYGDGAV 350
MGVPAHDERD FAFARKYGLT IRQVIAQEGK TYSDQAWQEW YGDKQTGRTI 400
NSGKYDGLST AEAVDAIAAD LNALGLGEKQ TTYRLRDWGI SRQRYWGTPI 450
PIIHCQDCGP VPVPEQDLPV VLPDDLIPDG SGNPLAKNEA FLSCSCPACG 500
KPARRETDTM DTFVDSSWYF MRYTSPGNDQ AMVDKRNDYW MPMDQYIGGI 550
EHAVLHLLYA RFWTKVMRDL GMLKFDEPFT RLLCQGMVLN HIYSRRTPQG 600
GIEYFWPEEV ENIYDAKGAI VGARLKSDGS EITYGGVGTM SKSKNNGVDP 650
QSLIDTLGAD TARLFVMFAS PPEQTLEWSD SGVDGANRFL RRLWALAYDR 700
RAAVARGLAS GYAWQDAPAP VKDLRRELYG LLKQAEYDYQ RIQYNTVVSA 750
SMKMLNAIDN AQLPEGPAAD AAIAEGLGLL LRVLYPVVPH VTWHIWRDLG 800
YAAELGDLLD APWPHVDEAA LIADEIELML QVNGKLRGAI RVAAQAAKED 850
IEKIAVAQEE VARFLEGRPP KRVIVVPGKL VNVVG 885
Length:885
Mass (Da):99,022
Last modified:March 7, 2006 - v1
Checksum:iA55D8D4B863156EF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM167904 Genomic DNA. Translation: CAJ50102.1.
RefSeqiYP_787004.1. NC_010645.1.

Genome annotation databases

GeneIDi6266007.
KEGGibav:BAV2492.
PATRICi21131223. VBIBorAvi43433_2516.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM167904 Genomic DNA. Translation: CAJ50102.1 .
RefSeqi YP_787004.1. NC_010645.1.

3D structure databases

ProteinModelPortali Q2KXE5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 360910.BAV2492.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 6266007.
KEGGi bav:BAV2492.
PATRICi 21131223. VBIBorAvi43433_2516.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi PVIHCPK.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci BAVI360910:GCKI-2539-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparison of the genome sequence of the poultry pathogen Bordetella avium with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals extensive diversity in surface structures associated with host interaction."
    Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D., King N.D., Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D., Goble A., Lord A., Murphy L., Quail M.A., Rutter S., Squares R., Squares S., Woodward J., Parkhill J., Temple L.M.
    J. Bacteriol. 188:6002-6015(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 197N.

Entry informationi

Entry nameiSYL_BORA1
AccessioniPrimary (citable) accession number: Q2KXE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 7, 2006
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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