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Q2KX31 (UPPP_BORA1) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA
Ordered Locus Names:BAV2566
OrganismBordetella avium (strain 197N) [Complete proteome] [HAMAP]
Taxonomic identifier360910 [NCBI]
Taxonomic lineageBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella

Protein attributes

Sequence length282 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 282282Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000290689

Regions

Transmembrane6 – 2621Helical; Potential
Transmembrane45 – 6521Helical; Potential
Transmembrane85 – 10521Helical; Potential
Transmembrane112 – 13221Helical; Potential
Transmembrane200 – 22021Helical; Potential
Transmembrane230 – 25021Helical; Potential
Transmembrane262 – 28221Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q2KX31 [UniParc].

Last modified June 12, 2007. Version 2.
Checksum: 881248254ED6A09C

FASTA28230,791
        10         20         30         40         50         60 
MTDSTLYFVK AFFLGIIEGL TEFIPVSSTG HLILFGDWIN FESGSGKVFE VVIQLGAILA 

        70         80         90        100        110        120 
VMWIFRARLW QLIRGTLSGQ RQEMLFTRNL LLAFFPAAII GAIFIKAIKQ TFYHPGVVAV 

       130        140        150        160        170        180 
TLVLGGLIML WVERRAPRSD GSASETATEE RATAHSLEEI SWKQALGVGV AQCLAMIPGT 

       190        200        210        220        230        240 
SRSGATIIGG MVAGIQRKTA TEFSFFLAMP TMLGAAVYDM YRNIDLLTSH DLGAIAVGFV 

       250        260        270        280 
AAFLSALLVV RAVLRFVANH TYRGFAWYRI ALGVVVAAWL AF 

« Hide

References

[1]"Comparison of the genome sequence of the poultry pathogen Bordetella avium with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals extensive diversity in surface structures associated with host interaction."
Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D., King N.D., Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D., Goble A., Lord A., Murphy L., Quail M.A., Rutter S., Squares R., Squares S., Woodward J., Parkhill J., Temple L.M.
J. Bacteriol. 188:6002-6015(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 197N.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM167904 Genomic DNA. Translation: CAJ50176.1. Sequence problems.
RefSeqYP_787074.1. NC_010645.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID6267313.
KEGGbav:BAV2566.
PATRIC21131399. VBIBorAvi43433_2595.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000218356.
KOK06153.

Enzyme and pathway databases

BioCycBAVI360910:GCKI-2623-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_BORA1
AccessionPrimary (citable) accession number: Q2KX31
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: June 12, 2007
Last modified: May 14, 2014
This is version 55 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families