Reviewed, UniProtKB/Swiss-Prot Q2KX26 (PUR5_BORA1)

Names and origin

Protein names

Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligase
    EC=6.3.3.1
Alternative name(s):
    AIRS
    Phosphoribosyl-aminoimidazole synthetase
    AIR synthase

Gene names

Name:	purM
Ordered Locus Names:	BAV0723

Organism

Bordetella avium (strain 197N) [Complete proteome] [HAMAP]

Taxonomic identifier

360910 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	349 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. HAMAP MF_00741
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/5. HAMAP MF_00741
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the AIR synthase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylformylglycinamidine cyclo-ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 349	349	Phosphoribosylformylglycinamidine cyclo-ligase HAMAP MF_00741		PRO_0000258335

Sequences

	Sequence		Length	Mass (Da)
	Q2KX26-1 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 96A469B4F964F477	FASTA	349	36,806
	10 20 30 40 50 60 MTNEHSAPLT YRDAGVDIDA GDALVDRIKP LAARTMRPGV LAGIGGFGAL FEVPKKYREP 70 80 90 100 110 120 VLVSGTDGVG TKLRLAFDWN RHDTVGIDLV AMSVNDILVQ GAEPLFFLDY FACGKLSVDT 130 140 150 160 170 180 AAAVVGGIAR GCELAGCALI GGETAEMPGM YPDGEYDLAG FAVGAVEKTA IIDGKSIQPG 190 200 210 220 230 240 DVVLGLASSG AHSNGYSLVR KILERAGARP DQDFHGQPLV DVVMAPTRIY VKQVLAALAE 250 260 270 280 290 300 HGTAIKGLAH ITGGGLLDNV PRILQQGLSA KLYRDGWQMP QLFQWLQQQG AVADTEMYRV 310 320 330 340 FNCGIGMVLV VAADQADAIS ATLRAQGEAV SRLGEIVPQQ DGMAQTFVV

References

[1]

"Comparison of the genome sequence of the poultry pathogen Bordetella avium with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals extensive diversity in surface structures associated with host interaction." Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D., King N.D., Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D., Goble A., Lord A., Murphy L., Quail M.A., Rutter S., Squares R., Squares S., Woodward J., Parkhill J., Temple L.M. J. Bacteriol. 188:6002-6015(2006) [PubMed: 16885469] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM167904 Genomic DNA. Translation: CAJ48333.1.
RefSeq	YP_785256.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6264932.
GenomeReviews	Gene locus BAV0723 in contig AM167904_GR.
KEGG	bav:BAV0723.
NMPDR	fig|521.1.peg.900.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2KX26.
OMA	Q2KX26. CGKLDPE.
Family and domain databases
HAMAP	MF_00741. [Tree]
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR004733. PurM_cligase. [Graphical view]
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
TIGRFAMs	TIGR00878. purM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PUR5_BORA1

Accession

Primary (citable) accession number: Q2KX26

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	March 7, 2006
Last modified:	June 16, 2009
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)