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Protein

Probable malate:quinone oxidoreductase

Gene

mqo

Organism
Bordetella avium (strain 197N)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-malate + a quinone = oxaloacetate + reduced quinone.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Probable malate:quinone oxidoreductase (mqo)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes oxaloacetate from (S)-malate (quinone route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciBAVI360910:GCKI-741-MONOMER.
UniPathwayiUPA00223; UER01008.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable malate:quinone oxidoreductaseUniRule annotation (EC:1.1.5.4UniRule annotation)
Alternative name(s):
MQOUniRule annotation
Malate dehydrogenase [quinone]UniRule annotation
Gene namesi
Name:mqoUniRule annotation
Ordered Locus Names:BAV0729
OrganismiBordetella avium (strain 197N)
Taxonomic identifieri360910 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
Proteomesi
  • UP000001977 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 500500Probable malate:quinone oxidoreductasePRO_0000325488Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi360910.BAV0729.

Structurei

3D structure databases

ProteinModelPortaliQ2KX12.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MQO family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DWT. Bacteria.
COG0579. LUCA.
HOGENOMiHOG000109379.
KOiK00116.
OMAiDLSRQFW.
OrthoDBiEOG6X6R8Z.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
HAMAPiMF_00212. MQO.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR006231. MQO.
[Graphical view]
PfamiPF06039. Mqo. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR01320. mal_quin_oxido. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2KX12-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTTSNLPEQ ADIVMIGAGI MSATLATVLK ALEPSLKIVM LETLNDCAME
60 70 80 90 100
SSNGWNNAGT GHAANCEMNY TPPRPDGTVD ISRALEVNTE FDLSRQLWSY
110 120 130 140 150
LVKTGAIPDP QAFIHPCPHM SMVWGADNVK YLRQRFKEMS AHHCYRGMEY
160 170 180 190 200
SEDPKQIAEW VPLVMQGRSG NEPIAVTRIV SGADVDYGAL THLLIKSLTE
210 220 230 240 250
QAGFEVHYLK HVHDLARQRD GSWRIGIRDR GSKAQQTIQA KFVFVGAGGG
260 270 280 290 300
AIELLQKSGI PEGHGYGGFP VSGIWLRCDV DSMSERHHAK VYGKAPHGSP
310 320 330 340 350
PMSVPHLDTR IIGGKRSLLF GPYAGFSSRF LKHGSLTDLF RSVRPGNVLP
360 370 380 390 400
MLDVAKDNWP LTEYLVSQVL QSAGHQFEML RQYYPEARNH DWTHAVAGQR
410 420 430 440 450
VQIIKPGTDK VGVLEFGTEL VTSADRSFAA LLGASPGAST AAFIALEVLQ
460 470 480 490 500
KCFADKLTAD AWLPRLKTVI PTYGVDLKTD AEACFSIRKS TASVLNLDYV
Length:500
Mass (Da):54,850
Last modified:March 7, 2006 - v1
Checksum:i938733533BC458FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM167904 Genomic DNA. Translation: CAJ48342.1.
RefSeqiWP_012416425.1. NC_010645.1.

Genome annotation databases

EnsemblBacteriaiCAJ48342; CAJ48342; BAV0729.
KEGGibav:BAV0729.
PATRICi21127622. VBIBorAvi43433_0746.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM167904 Genomic DNA. Translation: CAJ48342.1.
RefSeqiWP_012416425.1. NC_010645.1.

3D structure databases

ProteinModelPortaliQ2KX12.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi360910.BAV0729.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ48342; CAJ48342; BAV0729.
KEGGibav:BAV0729.
PATRICi21127622. VBIBorAvi43433_0746.

Phylogenomic databases

eggNOGiENOG4105DWT. Bacteria.
COG0579. LUCA.
HOGENOMiHOG000109379.
KOiK00116.
OMAiDLSRQFW.
OrthoDBiEOG6X6R8Z.

Enzyme and pathway databases

UniPathwayiUPA00223; UER01008.
BioCyciBAVI360910:GCKI-741-MONOMER.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
HAMAPiMF_00212. MQO.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR006231. MQO.
[Graphical view]
PfamiPF06039. Mqo. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
TIGRFAMsiTIGR01320. mal_quin_oxido. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Comparison of the genome sequence of the poultry pathogen Bordetella avium with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals extensive diversity in surface structures associated with host interaction."
    Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D., King N.D., Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D., Goble A., Lord A., Murphy L., Quail M.A., Rutter S., Squares R., Squares S., Woodward J., Parkhill J., Temple L.M.
    J. Bacteriol. 188:6002-6015(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 197N.

Entry informationi

Entry nameiMQO_BORA1
AccessioniPrimary (citable) accession number: Q2KX12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 7, 2006
Last modified: December 9, 2015
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.