ID   ADD_BORA1               Reviewed;         316 AA.
AC   Q2KWR7;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   16-JUN-2009, entry version 20.
DE   RecName: Full=Adenosine deaminase;
DE            EC=3.5.4.4;
DE   AltName: Full=Adenosine aminohydrolase;
GN   Name=add; OrderedLocusNames=BAV0774;
OS   Bordetella avium (strain 197N).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Bordetella.
OX   NCBI_TaxID=360910;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16885469; DOI=10.1128/JB.01927-05;
RA   Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D.,
RA   King N.D., Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D.,
RA   Goble A., Lord A., Murphy L., Quail M.A., Rutter S., Squares R.,
RA   Squares S., Woodward J., Parkhill J., Temple L.M.;
RT   "Comparison of the genome sequence of the poultry pathogen Bordetella
RT   avium with those of B. bronchiseptica, B. pertussis, and B.
RT   parapertussis reveals extensive diversity in surface structures
RT   associated with host interaction.";
RL   J. Bacteriol. 188:6002-6015(2006).
CC   -!- CATALYTIC ACTIVITY: Adenosine + H(2)O = inosine + NH(3).
CC   -!- SIMILARITY: Belongs to the adenosine and AMP deaminases family.
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DR   EMBL; AM167904; CAJ48386.1; -; Genomic_DNA.
DR   RefSeq; YP_785305.1; -.
DR   GeneID; 6264971; -.
DR   GenomeReviews; AM167904_GR; BAV0774.
DR   KEGG; bav:BAV0774; -.
DR   NMPDR; fig|521.1.peg.866; -.
DR   HOGENOM; Q2KWR7; -.
DR   OMA; Q2KWR7; LAQNSLD.
DR   GO; GO:0004000; F:adenosine deaminase activity; IEA:HAMAP.
DR   GO; GO:0009168; P:purine ribonucleoside monophosphate biosynt...; IEA:HAMAP.
DR   HAMAP; MF_00540; -; 1.
DR   InterPro; IPR006650; A/AMP_deam_AS.
DR   InterPro; IPR001365; A/AMP_deaminase.
DR   InterPro; IPR006330; A_deaminase.
DR   PANTHER; PTHR11409; A/AMP_deaminase; 1.
DR   Pfam; PF00962; A_deaminase; 1.
DR   TIGRFAMs; TIGR01430; aden_deam; 1.
DR   PROSITE; PS00485; A_DEAMINASE; FALSE_NEG.
PE   3: Inferred from homology;
KW   Complete proteome; Hydrolase; Nucleotide metabolism.
FT   CHAIN         1    316       Adenosine deaminase.
FT                                /FTId=PRO_1000017653.
FT   ACT_SITE    194    194       Potential.
FT   ACT_SITE    242    242       Potential.
FT   ACT_SITE    275    275       Potential.
FT   ACT_SITE    276    276       Potential.
SQ   SEQUENCE   316 AA;  35705 MW;  2700A01AF4AEB168 CRC64;
     MQDWLTALPK AELHIHLEGA LEPELLFALA QRNGVTLPWP DIDALRQAYQ YQNLQEFLDL
     YYQGAHVLRT EQDFYDLTWA YLRKCAEQGV THTEPFFDPQ THTDRGVPFQ VVLSGIQAAL
     ADGRRDLGIQ SGLILSFLRH LPEEAAMRTL DEALPYRDAF IAVGLDSSEA GFPPRLFERV
     FARARAEGLP AVAHAGEEGP PEYIWEALER LQVKRIDHGV RAWEDPRLIA HLVDTQIPLT
     VCPLSNVRLQ VFEHMGQHNV LEMLERGLNV CINSDDPAYF GGYVLENFMA LREHLGMSQE
     QARRLAANSL ASVLTA
//