Q2KWR7 (ADE_BORA1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenine deaminase
Short name=ADE
EC=3.5.4.2

Alternative name(s):
Adenine aminohydrolase
Short name=AAH

Gene names

Ordered Locus Names:

BAV0774

Organism

Bordetella avium (strain 197N) [Complete proteome] [HAMAP]

Taxonomic identifier

360910 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	316 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism By similarity. HAMAP MF_01962
Catalytic activity	Adenine + H2O = hypoxanthine + NH3. HAMAP MF_01962
Cofactor	Binds 1 zinc ion per subunit By similarity. HAMAP MF_01962
Sequence similarities	Belongs to the adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	adenine deaminase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 316	316	Adenine deaminase HAMAP MF_01962		PRO_1000017653
Sites
	Active site	197	1	Proton donor By similarity
	Metal binding	14	1	Zinc; catalytic By similarity
	Metal binding	16	1	Zinc; catalytic By similarity
	Metal binding	194	1	Zinc; catalytic By similarity
	Metal binding	275	1	Zinc; catalytic By similarity
	Binding site	276	1	Substrate By similarity
	Site	218	1	Important for catalytic activity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2KWR7 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 2700A01AF4AEB168	FASTA	316	35,705
	10 20 30 40 50 60 MQDWLTALPK AELHIHLEGA LEPELLFALA QRNGVTLPWP DIDALRQAYQ YQNLQEFLDL 70 80 90 100 110 120 YYQGAHVLRT EQDFYDLTWA YLRKCAEQGV THTEPFFDPQ THTDRGVPFQ VVLSGIQAAL 130 140 150 160 170 180 ADGRRDLGIQ SGLILSFLRH LPEEAAMRTL DEALPYRDAF IAVGLDSSEA GFPPRLFERV 190 200 210 220 230 240 FARARAEGLP AVAHAGEEGP PEYIWEALER LQVKRIDHGV RAWEDPRLIA HLVDTQIPLT 250 260 270 280 290 300 VCPLSNVRLQ VFEHMGQHNV LEMLERGLNV CINSDDPAYF GGYVLENFMA LREHLGMSQE 310 QARRLAANSL ASVLTA

References

[1]

"Comparison of the genome sequence of the poultry pathogen Bordetella avium with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals extensive diversity in surface structures associated with host interaction." Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D., King N.D., Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D., Goble A., Lord A., Murphy L., Quail M.A., Rutter S., Squares R., Squares S., Woodward J., Parkhill J., Temple L.M. J. Bacteriol. 188:6002-6015(2006) [PubMed: 16885469] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 197N.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM167904 Genomic DNA. Translation: CAJ48386.1.
RefSeq	YP_785305.1. NC_010645.1.
3D structure databases
ProteinModelPortal	Q2KWR7.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2KWR7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6264971.
GenomeReviews	Gene locus BAV0774 in contig AM167904_GR.
KEGG	bav:BAV0774.
NMPDR	fig|521.1.peg.866.
PATRIC	21127712. VBIBorAvi43433_0791.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG630382.
OMA	FGGYVDD.
ProtClustDB	PRK09358.
Enzyme and pathway databases
BioCyc	ABAU360910:BAV0774-MONOMER.
Family and domain databases
HAMAP	MF_01962. Adenine_deaminase. [Tree]
InterPro	IPR001365. A/AMP_deaminase_dom. IPR006330. A_deaminase. [Graphical view]
KO	K01488.
PANTHER	PTHR11409:SF21. PTHR11409:SF21. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. Aden_deam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ADE_BORA1

Accession

Primary (citable) accession number: Q2KWR7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	March 7, 2006
Last modified:	January 25, 2012
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program