Reviewed, UniProtKB/Swiss-Prot Q2KWR7 (ADD_BORA1)

Names and origin

Protein names

Recommended name:
    Adenosine deaminase
    EC=3.5.4.4
Alternative name(s):
    Adenosine aminohydrolase

Gene names

Name:	add
Ordered Locus Names:	BAV0774

Organism

Bordetella avium (strain 197N) [Complete proteome] [HAMAP]

Taxonomic identifier

360910 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	316 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Adenosine + H2O = inosine + NH3. HAMAP MF_00540
Sequence similarities	Belongs to the adenosine and AMP deaminases family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	adenosine deaminase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 316	316	Adenosine deaminase HAMAP MF_00540		PRO_1000017653
Sites
	Active site	194	1	Potential
	Active site	242	1	Potential
	Active site	275	1	Potential
	Active site	276	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q2KWR7-1 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 2700A01AF4AEB168	FASTA	316	35,705
	10 20 30 40 50 60 MQDWLTALPK AELHIHLEGA LEPELLFALA QRNGVTLPWP DIDALRQAYQ YQNLQEFLDL 70 80 90 100 110 120 YYQGAHVLRT EQDFYDLTWA YLRKCAEQGV THTEPFFDPQ THTDRGVPFQ VVLSGIQAAL 130 140 150 160 170 180 ADGRRDLGIQ SGLILSFLRH LPEEAAMRTL DEALPYRDAF IAVGLDSSEA GFPPRLFERV 190 200 210 220 230 240 FARARAEGLP AVAHAGEEGP PEYIWEALER LQVKRIDHGV RAWEDPRLIA HLVDTQIPLT 250 260 270 280 290 300 VCPLSNVRLQ VFEHMGQHNV LEMLERGLNV CINSDDPAYF GGYVLENFMA LREHLGMSQE 310 QARRLAANSL ASVLTA

References

[1]

"Comparison of the genome sequence of the poultry pathogen Bordetella avium with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals extensive diversity in surface structures associated with host interaction." Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D., King N.D., Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D., Goble A., Lord A., Murphy L., Quail M.A., Rutter S., Squares R., Squares S., Woodward J., Parkhill J., Temple L.M. J. Bacteriol. 188:6002-6015(2006) [PubMed: 16885469] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM167904 Genomic DNA. Translation: CAJ48386.1.
RefSeq	YP_785305.1.
3D structure databases
SMR	Q2KWR7. Positions 7-312.
ModBase	Search...
Genome annotation databases
GeneID	6264971.
GenomeReviews	Gene locus BAV0774 in contig AM167904_GR.
KEGG	bav:BAV0774.
NMPDR	fig|521.1.peg.866.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG630382.
OMA	DERLMQR.
Family and domain databases
HAMAP	MF_00540. A_deaminase. [Tree]
InterPro	IPR001365. A/AMP_deaminase. IPR006330. A_deaminase. [Graphical view]
PANTHER	PTHR11409. A/AMP_deaminase. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. aden_deam. 1 hit.
PROSITE	PS00485. A_DEAMINASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADD_BORA1

Accession

Primary (citable) accession number: Q2KWR7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	March 7, 2006
Last modified:	February 9, 2010
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)