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Protein

Fructose-1,6-bisphosphate aldolase

Gene

fba

Organism
Bordetella avium (strain 197N)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.UniRule annotation

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: One is catalytic and the other provides a structural contribution.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. no protein annotated in this organism
  4. Fructose-1,6-bisphosphate aldolase (fba)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei83Proton donorUniRule annotation1
Binding sitei199Dihydroxyacetone phosphate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotationImported
Biological processGlycolysisUniRule annotation
LigandMetal-bindingUniRule annotationSAAS annotation, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciBAVI360910:G1GJZ-909-MONOMER
UniPathwayiUPA00109; UER00183

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-1,6-bisphosphate aldolaseUniRule annotation (EC:4.1.2.13UniRule annotation)
Short name:
FBP aldolaseUniRule annotation
Gene namesi
Name:fbaImported
Ordered Locus Names:BAV0889Imported
OrganismiBordetella avium (strain 197N)Imported
Taxonomic identifieri360910 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
Proteomesi
  • UP000001977 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi360910.BAV0889

Structurei

3D structure databases

ProteinModelPortaliQ2KW09
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni233 – 235Dihydroxyacetone phosphate bindingUniRule annotation3
Regioni275 – 278Dihydroxyacetone phosphate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the class II fructose-bisphosphate aldolase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105D2N Bacteria
COG0191 LUCA
HOGENOMiHOG000227792
KOiK01624
OMAiELCKDCI

Family and domain databases

CDDicd00947 TBP_aldolase_IIB, 1 hit
Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR000771 FBA_II
IPR006412 Fruct_bisP_Calv
PfamiView protein in Pfam
PF01116 F_bP_aldolase, 1 hit
PIRSFiPIRSF001359 F_bP_aldolase_II, 1 hit
TIGRFAMsiTIGR00167 cbbA, 1 hit
TIGR01521 FruBisAldo_II_B, 1 hit
PROSITEiView protein in PROSITE
PS00602 ALDOLASE_CLASS_II_1, 1 hit
PS00806 ALDOLASE_CLASS_II_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q2KW09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALVSMRQLL DHAAEHGYGI PAFNVNNLEQ VQAIMEAAAE TDSPVIMQAS
60 70 80 90 100
AGARKYAGEG FLKYLIQAAV ESYPHIPVVM HQDHGQSPAV CQGAINLGFS
110 120 130 140 150
SVMMDGSLKE DGKTIADYEY NVEVTRKVVD MAHKLGVTVE GELGCLGSLE
160 170 180 190 200
TMEGDKEDGH GADGKLTLEQ LLTDPEQAAD FVRRTQLDAL AIAIGTSHGA
210 220 230 240 250
YKFTRKPTGD ILSIKRIKEI HARLPNTHLV MHGSSSVPQE LLAEIREFGG
260 270 280 290 300
DMKETYGVPV EEIQEAIKYG VRKINIDTDI RLAMTGAVRR FFAENPGKFD
310 320 330 340 350
PREYLKPARA AAKAICVARY TEFGAAGNGS KIKPIPLAEI AQQYAAGKLA

QLVQ
Length:354
Mass (Da):38,407
Last modified:March 7, 2006 - v1
Checksum:i0DD4F8E0A8024DBF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM167904 Genomic DNA Translation: CAJ48500.1
RefSeqiWP_012416580.1, NC_010645.1

Genome annotation databases

EnsemblBacteriaiCAJ48500; CAJ48500; BAV0889
KEGGibav:BAV0889

Similar proteinsi

Entry informationi

Entry nameiQ2KW09_BORA1
AccessioniPrimary (citable) accession number: Q2KW09
Entry historyiIntegrated into UniProtKB/TrEMBL: March 7, 2006
Last sequence update: March 7, 2006
Last modified: June 20, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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