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Protein

Glutamate decarboxylase

Gene

gadA2

Organism
Bordetella avium (strain 197N)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciBAVI360910:GCKI-2862-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Name:gadA2Imported
Ordered Locus Names:BAV2797Imported
OrganismiBordetella avium (strain 197N)Imported
Taxonomic identifieri360910 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
ProteomesiUP000001977 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi360910.BAV2797.

Structurei

3D structure databases

ProteinModelPortaliQ2KVV2.
SMRiQ2KVV2. Positions 9-466.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
KOiK01580.
OMAiHINRVAT.
OrthoDBiEOG6TFCPW.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2KVV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLHAKHSLR TALLDDVFAS DDLAAPLPRH RFPVTQQTAQ HAYQAVHDEL
60 70 80 90 100
MLDGNSRQNL ATFCQTWLDA ETHRLMDESI DKNMIDKDEY PQTAELEARC
110 120 130 140 150
VHMLADLWNA PEAENPTGCS TIGSSEAAML GGLAMKWAWR GRRKAAGKPS
160 170 180 190 200
DQPNLICGPV QICWHKFARY FDVELREIPM EHGRLIMSPE EVLKRADENT
210 220 230 240 250
IGVVPTLGVT YTCQYEPVTA VHQALDRLQQ ETGLDIPMHI DGASGAFLAP
260 270 280 290 300
FCAPDLVWDF RLPRVVSINA SGHKFGLAPL GVGWVIWRDA KHLPEDLIFN
310 320 330 340 350
VNYLGGNMPT FALNFSRPGG QIVAQYYNFL RLGREGYQSI QNACYDTAQY
360 370 380 390 400
LAREIAALGP FEILVDGNPA HGIPGLCWKI KDGQKDPGFT LYDMADRLRT
410 420 430 440 450
RGWQVPAYSL PANRQDLVIQ RILVRHGVSR DLASLLIDDF KRAMAYFRTH
460
TITTSTADKP ANAFHH
Length:466
Mass (Da):52,211
Last modified:March 6, 2006 - v1
Checksum:i31064823984CD2EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM167904 Genomic DNA. Translation: CAJ50408.1.
RefSeqiWP_012418439.1. NC_010645.1.
YP_787295.1. NC_010645.1.

Genome annotation databases

EnsemblBacteriaiCAJ50408; CAJ50408; BAV2797.
KEGGibav:BAV2797.
PATRICi21131885. VBIBorAvi43433_2830.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM167904 Genomic DNA. Translation: CAJ50408.1.
RefSeqiWP_012418439.1. NC_010645.1.
YP_787295.1. NC_010645.1.

3D structure databases

ProteinModelPortaliQ2KVV2.
SMRiQ2KVV2. Positions 9-466.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi360910.BAV2797.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ50408; CAJ50408; BAV2797.
KEGGibav:BAV2797.
PATRICi21131885. VBIBorAvi43433_2830.

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
KOiK01580.
OMAiHINRVAT.
OrthoDBiEOG6TFCPW.

Enzyme and pathway databases

BioCyciBAVI360910:GCKI-2862-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Comparison of the genome sequence of the poultry pathogen Bordetella avium with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals extensive diversity in surface structures associated with host interaction."
    Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D., King N.D., Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D., Goble A., Lord A., Murphy L., Quail M.A., Rutter S., Squares R., Squares S., Woodward J., Parkhill J., Temple L.M.
    J. Bacteriol. 188:6002-6015(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 197NImported.

Entry informationi

Entry nameiQ2KVV2_BORA1
AccessioniPrimary (citable) accession number: Q2KVV2
Entry historyi
Integrated into UniProtKB/TrEMBL: March 6, 2006
Last sequence update: March 6, 2006
Last modified: March 31, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.