Reviewed, UniProtKB/Swiss-Prot Q2KVG1 (MURC_BORA1)

Names and origin

Protein names

Recommended name:
    UDP-N-acetylmuramate--L-alanine ligase
    EC=6.3.2.8
Alternative name(s):
    UDP-N-acetylmuramoyl-L-alanine synthetase

Gene names

Name:	murC
Ordered Locus Names:	BAV2878

Organism

Bordetella avium (strain 197N) [Complete proteome] [HAMAP]

Taxonomic identifier

360910 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	468 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Cell wall formation By similarity.
Catalytic activity	ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine. HAMAP MF_00046
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00046
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the murCDEF family.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP UDP-N-acetylmuramate-L-alanine ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 468	468	UDP-N-acetylmuramate--L-alanine ligase HAMAP MF_00046		PRO_0000242544
Regions
	Nucleotide binding	112 – 118	7	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q2KVG1-1 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 95FA706C1729B7E4	FASTA	468	49,594
	10 20 30 40 50 60 MKHRIQHIHF VGVGGSGMSG IAEVLLNLGY TVSGSDLSES TVTRRLADLG LKVSIGHAAE 70 80 90 100 110 120 NVADADAIVT STAVAGDNPE VIAARLARIP VVPRAVMLAE LMRLKRGIAV AGTHGKTTTT 130 140 150 160 170 180 SLVASVLAAG GLDPTFVIGG RLNSAGANAQ LGQGEFIVVE ADESDASFLN LLPVMAIITN 190 200 210 220 230 240 IDADHMDTYG HDVARLKSAF IEFTQRLPFY GSAVLCADDA NVREIMPFVS RPITTYGLSS 250 260 270 280 290 300 DAQVRAENVQ ADGTRMRFSV RRQGREQDLP TLEVELNLPG LHNVRNALAA IAVASELGVA 310 320 330 340 350 360 DAAICQALAG FKGVGRRFTQ WGEFPVAEAQ GGGRYSVIDD YGHHPVEMAA TLAAARGAWP 370 380 390 400 410 420 DRRIVLAFQP HRYTRTRDCF EDFVRVLGTA DAVLLTEVYA AGEAPLVAAD GRALARALRV 430 440 450 460 AGKVEPLFVE DVAALPQAVR DFMRDGDVLI LMGAGSISKV PSQLGEHA

References

[1]

"Comparison of the genome sequence of the poultry pathogen Bordetella avium with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals extensive diversity in surface structures associated with host interaction." Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D., King N.D., Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D., Goble A., Lord A., Murphy L., Quail M.A., Rutter S., Squares R., Squares S., Woodward J., Parkhill J., Temple L.M. J. Bacteriol. 188:6002-6015(2006) [PubMed: 16885469] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM167904 Genomic DNA. Translation: CAJ50488.1.
RefSeq	YP_787374.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6266871.
GenomeReviews	Gene locus BAV2878 in contig AM167904_GR.
KEGG	bav:BAV2878.
NMPDR	fig|521.1.peg.449.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2KVG1.
OMA	EWMVVEA.
Family and domain databases
HAMAP	MF_00046. [Tree]
InterPro	IPR004101. Mur_ligase_C. IPR013221. Mur_ligase_cen. IPR000713. Mur_ligase_N. IPR016040. NAD(P)-bd_dom. IPR005758. UDP-N-AcMur_Ala_ligase. [Graphical view]
Gene3D	G3DSA:3.90.190.20. Mur_ligase_C. 1 hit. G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01225. Mur_ligase. 1 hit. PF02875. Mur_ligase_C. 1 hit. PF08245. Mur_ligase_M. 1 hit. [Graphical view]
TIGRFAMs	TIGR01082. murC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MURC_BORA1

Accession

Primary (citable) accession number: Q2KVG1

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	March 7, 2006
Last modified:	November 3, 2009
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)