ID   MURD_BORA1              Reviewed;         508 AA.
AC   Q2KVF5;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   16-JUN-2009, entry version 31.
DE   RecName: Full=UDP-N-acetylmuramoylalanine--D-glutamate ligase;
DE            EC=6.3.2.9;
DE   AltName: Full=UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase;
DE   AltName: Full=D-glutamic acid-adding enzyme;
GN   Name=murD; OrderedLocusNames=BAV2881;
OS   Bordetella avium (strain 197N).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Bordetella.
OX   NCBI_TaxID=360910;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16885469; DOI=10.1128/JB.01927-05;
RA   Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D.,
RA   King N.D., Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D.,
RA   Goble A., Lord A., Murphy L., Quail M.A., Rutter S., Squares R.,
RA   Squares S., Woodward J., Parkhill J., Temple L.M.;
RT   "Comparison of the genome sequence of the poultry pathogen Bordetella
RT   avium with those of B. bronchiseptica, B. pertussis, and B.
RT   parapertussis reveals extensive diversity in surface structures
RT   associated with host interaction.";
RL   J. Bacteriol. 188:6002-6015(2006).
CC   -!- FUNCTION: Cell wall formation. Catalyzes the addition of glutamate
CC       to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CC       (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + UDP-N-acetylmuramoyl-L-alanine +
CC       glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-
CC       glutamate.
CC   -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the murCDEF family.
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DR   EMBL; AM167904; CAJ50491.1; -; Genomic_DNA.
DR   RefSeq; YP_787377.1; -.
DR   GeneID; 6267041; -.
DR   GenomeReviews; AM167904_GR; BAV2881.
DR   KEGG; bav:BAV2881; -.
DR   NMPDR; fig|521.1.peg.453; -.
DR   HOGENOM; Q2KVF5; -.
DR   OMA; Q2KVF5; SEDHLDR.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0008764; F:UDP-N-acetylmuramoylalanine-D-glutamate lig...; IEA:HAMAP.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007047; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:HAMAP.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   HAMAP; MF_00639; -; 1.
DR   InterPro; IPR004101; Mur_ligase_C.
DR   InterPro; IPR013221; Mur_ligase_cen.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR005762; UDP-N-AcMur-Glu_ligase.
DR   Gene3D; G3DSA:3.90.190.20; Mur_ligase_C; 1.
DR   Gene3D; G3DSA:3.40.1190.10; Mur_ligase_cen; 1.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Pfam; PF02875; Mur_ligase_C; 1.
DR   Pfam; PF08245; Mur_ligase_M; 1.
DR   TIGRFAMs; TIGR01087; murD; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell cycle; Cell division; Cell shape;
KW   Cell wall biogenesis/degradation; Complete proteome; Cytoplasm;
KW   Ligase; Nucleotide-binding; Peptidoglycan synthesis.
FT   CHAIN         1    508       UDP-N-acetylmuramoylalanine--D-glutamate
FT                                ligase.
FT                                /FTId=PRO_0000257168.
FT   NP_BIND     138    144       ATP (Potential).
SQ   SEQUENCE   508 AA;  53709 MW;  8BB3FE665391C7A1 CRC64;
     MNTELTSRAD APLVLILGLG ETGVAAARWC AREGARLRVA DTRMQPGGLE GLRAVLQEAQ
     VEYHLGCGSH FDPALLDGVT QLVLSPGLAP GQEPAASLLA AAVSRGIEVL GEVELFARAL
     ASLAEARAYH PRLLAVTGTN GKTTVTALTR QLIEACGLSA RAAGNISPAA LASLMEALDQ
     DALPDVWVLE LSSFQLETTH SLQADAAVVL NVTQDHLDWH GDMQAYAQAK ARLLKMARVA
     IVNRDDPLTL AMVADVNGLN VRSFGRDLPQ RVGDMGLELG QGVAWLVACE PSDFDEPVVR
     RKKDAPPPQR GEGRMSRLMP VDALRIRGVH NALNALAALQ LARVLELGWG PMLRALRDYA
     GEPHRAAFVR SIGGVDYIND SKGTNVGATV AALEGLGQTV VLIAGGQGKG QDFSPLRSAV
     SRHARAVVLI GADGPAIGQV LESTGVALVV AADMREAVRR AAEIAQAGEA VLLSPACASL
     DMYRNYPHRG QVFVEEVEEL ALDRGEVL
//