Reviewed, UniProtKB/Swiss-Prot Q2KV05 (ARGC_BORA1)

Names and origin

Protein names

Recommended name:
    N-acetyl-gamma-glutamyl-phosphate reductase
      Short name=AGPR
    EC=1.2.1.38
Alternative name(s):
    N-acetyl-glutamate semialdehyde dehydrogenase
      Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	BAV2968

Organism

Bordetella avium (strain 197N) [Complete proteome] [HAMAP]

Taxonomic identifier

360910 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	353 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: HAMAP NAD or NADH binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 353	353	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_1000010980
Sites
	Active site	157	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2KV05-1 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 13470C45E0A99F61	FASTA	353	37,886
	10 20 30 40 50 60 MAQARNSRIK VGIVGGTGYT GVELLRLLSQ HPDVELTAIT SRKEDGLPVA EMYPNLRGHV 70 80 90 100 110 120 KLAFSAPEKA SLTDCDVVFF ATPHGVAMAQ AQALTAAGTR VIDLAADFRL QDTASFERWY 130 140 150 160 170 180 KMPHGCPDIL AKQSAYGLVE LNRAAIAQAQ VIGNPGCYPT TVILGLAPLL ERKLIDTQAL 190 200 210 220 230 240 IADCKSGVSG AGRKAEVASL FSEASDNFKA YGVAGHRHHP EITEQLEKLA GGKVGLTFVP 250 260 270 280 290 300 HLVPMIRGMF STIYARILPE ARETDFQALF EERYAGEAFI DVMPAGSLPE TRSVRASNNL 310 320 330 340 350 RIAVQRPGNG DQLIVLVVQD NLVKGAAGQA VQNMNLMFGL PETTGLNQVA ILP

References

[1]

"Comparison of the genome sequence of the poultry pathogen Bordetella avium with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals extensive diversity in surface structures associated with host interaction." Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D., King N.D., Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D., Goble A., Lord A., Murphy L., Quail M.A., Rutter S., Squares R., Squares S., Woodward J., Parkhill J., Temple L.M. J. Bacteriol. 188:6002-6015(2006) [PubMed: 16885469] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM167904 Genomic DNA. Translation: CAJ50578.1.
RefSeq	YP_787463.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6266304.
GenomeReviews	Gene locus BAV2968 in contig AM167904_GR.
KEGG	bav:BAV2968.
NMPDR	fig|521.1.peg.2221.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2KV05.
OMA	Q2KV05. VCRIAVH.
Family and domain databases
HAMAP	MF_00150. [Tree]
InterPro	IPR000706. AGPR_act_site. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
ProDom	PD003765. AGPR_act_site. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01850. argC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_BORA1

Accession

Primary (citable) accession number: Q2KV05

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	March 7, 2006
Last modified:	June 16, 2009
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)