ID   AROE_BORA1              Reviewed;         285 AA.
AC   Q2KUU3;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   16-JUN-2009, entry version 30.
DE   RecName: Full=Shikimate dehydrogenase;
DE            EC=1.1.1.25;
GN   Name=aroE; OrderedLocusNames=BAV3004;
OS   Bordetella avium (strain 197N).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Bordetella.
OX   NCBI_TaxID=360910;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16885469; DOI=10.1128/JB.01927-05;
RA   Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D.,
RA   King N.D., Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D.,
RA   Goble A., Lord A., Murphy L., Quail M.A., Rutter S., Squares R.,
RA   Squares S., Woodward J., Parkhill J., Temple L.M.;
RT   "Comparison of the genome sequence of the poultry pathogen Bordetella
RT   avium with those of B. bronchiseptica, B. pertussis, and B.
RT   parapertussis reveals extensive diversity in surface structures
RT   associated with host interaction.";
RL   J. Bacteriol. 188:6002-6015(2006).
CC   -!- CATALYTIC ACTIVITY: Shikimate + NADP(+) = 3-dehydroshikimate +
CC       NADPH.
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and PEP:
CC       step 4/7.
CC   -!- SIMILARITY: Belongs to the shikimate dehydrogenase family.
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DR   EMBL; AM167904; CAJ50614.1; -; Genomic_DNA.
DR   RefSeq; YP_787499.1; -.
DR   GeneID; 6266320; -.
DR   GenomeReviews; AM167904_GR; BAV3004.
DR   KEGG; bav:BAV3004; -.
DR   NMPDR; fig|521.1.peg.2527; -.
DR   HOGENOM; Q2KUU3; -.
DR   OMA; Q2KUU3; RIVIANR.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0050661; F:NADP or NADPH binding; IEA:InterPro.
DR   GO; GO:0004764; F:shikimate 5-dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic pro...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00222; -; 1.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR011342; Quinate/shikimate_5-DH.
DR   InterPro; IPR013708; Shikimate_DH-bd_N.
DR   InterPro; IPR006151; Shikm_DH/Glu-tRNA_Rdtase.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Pfam; PF01488; Shikimate_DH; 1.
DR   Pfam; PF08501; Shikimate_dh_N; 1.
DR   TIGRFAMs; TIGR00507; aroE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; NADP; Oxidoreductase.
FT   CHAIN         1    285       Shikimate dehydrogenase.
FT                                /FTId=PRO_0000325105.
FT   NP_BIND     132    136       NADP (By similarity).
FT   ACT_SITE     71     71       Proton acceptor (Potential).
SQ   SEQUENCE   285 AA;  29661 MW;  92BC0419AA11D4CF CRC64;
     MTSRPALRRY AVIGNPITHS RSPQIHAMFA AQTGISLEYE RIPAPLDGFR ATAEAFFLAG
     GQGLNVTVPF KQEAFELARE HLSARARMAG AVNTLTWRDG VLQGCNTDGV GLVNDLIRLG
     VMLQGARLLL VGAGGAARGV LQPLAEAGCA EIRIVNRSPG RAAELLAAWT ASGIPGGVQT
     SAGALDEAGG AWDIVINATA SSLHDLAPAL PGGLYAPGAL AYDMVYGARP TPFMRQARAD
     GAALTADGLG MLVGQAAESF FIWHGLRPDP TAVLTTLRAN LLAED
//