Reviewed, UniProtKB/Swiss-Prot Q2KUU3 (AROE_BORA1)

Names and origin

Protein names

Recommended name:
    Shikimate dehydrogenase
    EC=1.1.1.25

Gene names

Name:	aroE
Ordered Locus Names:	BAV3004

Organism

Bordetella avium (strain 197N) [Complete proteome] [HAMAP]

Taxonomic identifier

360910 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	285 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and PEP: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	NADP or NADPH binding Inferred from electronic annotation. Source: InterPro shikimate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 285	285	Shikimate dehydrogenase HAMAP MF_00222		PRO_0000325105
Regions
	Nucleotide binding	132 – 136	5	NADP By similarity
Sites
	Active site	71	1	Proton acceptor Potential

Sequences

	Sequence		Length	Mass (Da)
	Q2KUU3-1 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 92BC0419AA11D4CF	FASTA	285	29,661
	10 20 30 40 50 60 MTSRPALRRY AVIGNPITHS RSPQIHAMFA AQTGISLEYE RIPAPLDGFR ATAEAFFLAG 70 80 90 100 110 120 GQGLNVTVPF KQEAFELARE HLSARARMAG AVNTLTWRDG VLQGCNTDGV GLVNDLIRLG 130 140 150 160 170 180 VMLQGARLLL VGAGGAARGV LQPLAEAGCA EIRIVNRSPG RAAELLAAWT ASGIPGGVQT 190 200 210 220 230 240 SAGALDEAGG AWDIVINATA SSLHDLAPAL PGGLYAPGAL AYDMVYGARP TPFMRQARAD 250 260 270 280 GAALTADGLG MLVGQAAESF FIWHGLRPDP TAVLTTLRAN LLAED

References

[1]

"Comparison of the genome sequence of the poultry pathogen Bordetella avium with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals extensive diversity in surface structures associated with host interaction." Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D., King N.D., Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D., Goble A., Lord A., Murphy L., Quail M.A., Rutter S., Squares R., Squares S., Woodward J., Parkhill J., Temple L.M. J. Bacteriol. 188:6002-6015(2006) [PubMed: 16885469] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM167904 Genomic DNA. Translation: CAJ50614.1.
RefSeq	YP_787499.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6266320.
GenomeReviews	Gene locus BAV3004 in contig AM167904_GR.
KEGG	bav:BAV3004.
NMPDR	fig|521.1.peg.2527.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q2KUU3.
OMA	Q2KUU3. RIVIANR.
Family and domain databases
HAMAP	MF_00222. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Quinate/shikimate_5-DH. IPR013708. Shikimate_DH-bd_N. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. aroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROE_BORA1

Accession

Primary (citable) accession number: Q2KUU3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	March 7, 2006
Last modified:	June 16, 2009
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)