ID   TRPC_BORA1              Reviewed;         262 AA.
AC   Q2KU99;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   16-JUN-2009, entry version 25.
DE   RecName: Full=Indole-3-glycerol phosphate synthase;
DE            Short=IGPS;
DE            EC=4.1.1.48;
GN   Name=trpC; OrderedLocusNames=BAV3152;
OS   Bordetella avium (strain 197N).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Bordetella.
OX   NCBI_TaxID=360910;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16885469; DOI=10.1128/JB.01927-05;
RA   Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D.,
RA   King N.D., Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D.,
RA   Goble A., Lord A., Murphy L., Quail M.A., Rutter S., Squares R.,
RA   Squares S., Woodward J., Parkhill J., Temple L.M.;
RT   "Comparison of the genome sequence of the poultry pathogen Bordetella
RT   avium with those of B. bronchiseptica, B. pertussis, and B.
RT   parapertussis reveals extensive diversity in surface structures
RT   associated with host interaction.";
RL   J. Bacteriol. 188:6002-6015(2006).
CC   -!- CATALYTIC ACTIVITY: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-
CC       phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO(2) + H(2)O.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 4/5.
CC   -!- SIMILARITY: Belongs to the trpC family.
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DR   EMBL; AM167904; CAJ50761.1; -; Genomic_DNA.
DR   RefSeq; YP_787646.1; -.
DR   GeneID; 6266408; -.
DR   GenomeReviews; AM167904_GR; BAV3152.
DR   KEGG; bav:BAV3152; -.
DR   NMPDR; fig|521.1.peg.2087; -.
DR   HOGENOM; Q2KU99; -.
DR   OMA; Q2KU99; PLLCKDF.
DR   GO; GO:0004425; F:indole-3-glycerol-phosphate synthase activity; IEA:HAMAP.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00134; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR013798; Indole-3-glycerol_P_synth.
DR   InterPro; IPR001468; Indole-3-GPS_central.
DR   Gene3D; G3DSA:3.20.20.70; Aldolase_TIM; 1.
DR   Pfam; PF00218; IGPS; 1.
DR   ProDom; PD001511; IGPS; 1.
DR   PROSITE; PS00614; IGPS; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; Decarboxylase; Lyase; Tryptophan biosynthesis.
FT   CHAIN         1    262       Indole-3-glycerol phosphate synthase.
FT                                /FTId=PRO_1000018442.
SQ   SEQUENCE   262 AA;  28501 MW;  0C3CDE02B4E72129 CRC64;
     MNDILAKILA VKAEEVATAR QMRSEAELLR EAQARQDVRG FAQAIEDKIA QGKPGVIAEI
     KKASPSKGVL RENFDASEIA ASYAAHGAAC LSVLTDVQFF QGSHDNLRRA RAACPLPVLR
     KDFILDPYQI ISARAMGADC VLLIVAALSP TQLRDLEAVA MDLGMDVLVE VHDEAELDVA
     LGMKTPLLGI NNRNLRSFET RLETTLNLLP RIPAGKRVVT ESGILQPDDV QLMRRHGVQA
     FLVGEAFMRA EEPGAELARL VA
//