Q2KU21 (DSBC_BORA1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable thiol:disulfide interchange protein DsbC

Gene names

Name:	dsbC
Ordered Locus Names:	BAV3229

Organism

Bordetella avium (strain 197N) [Complete proteome] [HAMAP]

Taxonomic identifier

360910 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Alcaligenaceae › Bordetella

Protein attributes

Sequence length	277 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process By similarity.
Subcellular location	Periplasm By similarity.
Sequence similarities	Belongs to the thioredoxin family. DsbC subfamily.

Ontologies

Keywords
Cellular component	Periplasm
Domain	Redox-active center Signal
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro
Cellular component	periplasmic space Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 277	258	Probable thiol:disulfide interchange protein DsbC		PRO_0000245642
Amino acid modifications
	Disulfide bond	166 ↔ 169		Redox-active By similarity
	Disulfide bond	205 ↔ 228		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q2KU21 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: CFE1A60C9737C1BD	FASTA	277	30,568
	10 20 30 40 50 60 MKARIIVLLA SLLCANAYAQ NGYSASTAQS SGQNDTVYST NQVGKPATNG GKVYSTTQVQ 70 80 90 100 110 120 PPDPVTDAVR KRFQLRFQDL KIGVVRPTPY GLFEVQLGGD MFYTDKDVSW VMKGPLIDAA 130 140 150 160 170 180 TRRDVTRENL EKLSAVSFSE LPLDLAIKQV KGQGKHRIAI FEDPNCGYCK QLRHTLKEMD 190 200 210 220 230 240 DVTIYTFLYP ILSPDSTVKA RDVLCAADPG KVLDAWMLEG KPPAPAHCRA PIEELVALGE 250 260 270 KLRVRGTPTL FFEDNTRAAG VLPPAQLRER LTRNVSQ

References

[1]

"Comparison of the genome sequence of the poultry pathogen Bordetella avium with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals extensive diversity in surface structures associated with host interaction." Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D., King N.D., Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D., Goble A., Lord A., Murphy L., Quail M.A., Rutter S., Squares R., Squares S., Woodward J., Parkhill J., Temple L.M. J. Bacteriol. 188:6002-6015(2006) [PubMed: 16885469] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 197N.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM167904 Genomic DNA. Translation: CAJ50839.1.
RefSeq	YP_787724.1. NC_010645.1.
3D structure databases
ProteinModelPortal	Q2KU21.
ModBase	Search...
Protein-protein interaction databases
STRING	Q2KU21.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6266446.
GenomeReviews	Gene locus BAV3229 in contig AM167904_GR.
KEGG	bav:BAV3229.
NMPDR	fig|521.1.peg.2017.
PATRIC	21132777. VBIBorAvi43433_3265.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG469935.
OMA	QRNLAFG.
ProtClustDB	CLSK921008.
Enzyme and pathway databases
BioCyc	ABAU360910:BAV3229-MONOMER.
Family and domain databases
InterPro	IPR018950. DiS-bond_isomerase_DsbC/G_N. IPR009094. DiS-bond_isomerase_DsbC_N. IPR012336. Thioredoxin-like_fold. IPR017937. Thioredoxin_CS. [Graphical view]
Gene3D	G3DSA:3.10.450.70. Disulf_isomers_N. 1 hit. G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
KO	K03981.
Pfam	PF10411. DsbC_N. 1 hit. [Graphical view]
SUPFAM	SSF54423. Disulfide_bond_isomerase_N. 1 hit. SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS00194. THIOREDOXIN_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DSBC_BORA1

Accession

Primary (citable) accession number: Q2KU21

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
Last sequence update:	March 7, 2006
Last modified:	January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program