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Q2KTT0

- HIS3_BORA1

UniProt

Q2KTT0 - HIS3_BORA1

Protein

Phosphoribosyl-AMP cyclohydrolase

Gene

hisI

Organism
Bordetella avium (strain 197N)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
  1. Functioni

    Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.UniRule annotation

    Catalytic activityi

    1-(5-phospho-beta-D-ribosyl)-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide.UniRule annotation

    Cofactori

    Binds 1 magnesium ion per subunit.UniRule annotation
    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi80 – 801MagnesiumUniRule annotation
    Metal bindingi81 – 811Zinc; shared with dimeric partnerUniRule annotation
    Metal bindingi82 – 821MagnesiumUniRule annotation
    Metal bindingi84 – 841MagnesiumUniRule annotation
    Metal bindingi98 – 981Zinc; shared with dimeric partnerUniRule annotation
    Metal bindingi105 – 1051Zinc; shared with dimeric partnerUniRule annotation

    GO - Molecular functioni

    1. phosphoribosyl-AMP cyclohydrolase activity Source: UniProtKB-EC

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Magnesium, Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciBAVI360910:GCKI-3397-MONOMER.
    UniPathwayiUPA00031; UER00008.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosyl-AMP cyclohydrolaseUniRule annotation (EC:3.5.4.19UniRule annotation)
    Short name:
    PRA-CHUniRule annotation
    Gene namesi
    Name:hisIUniRule annotation
    Ordered Locus Names:BAV3320
    OrganismiBordetella avium (strain 197N)
    Taxonomic identifieri360910 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
    ProteomesiUP000001977: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 134134Phosphoribosyl-AMP cyclohydrolasePRO_1000063390Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi360910.BAV3320.

    Structurei

    3D structure databases

    ProteinModelPortaliQ2KTT0.
    SMRiQ2KTT0. Positions 14-112.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PRA-CH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0139.
    HOGENOMiHOG000277504.
    KOiK01496.
    OMAiHEPGIAC.
    OrthoDBiEOG6PGKB6.

    Family and domain databases

    HAMAPiMF_01021. HisI.
    InterProiIPR026660. PRA-CH.
    IPR002496. PRib_AMP_CycHydrolase_dom.
    [Graphical view]
    PfamiPF01502. PRA-CH. 1 hit.
    [Graphical view]
    ProDomiPD002610. PRA_CycHdrlase. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    Q2KTT0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTEPDWMAD VVFDADGLIP AIAQDAENGQ ILMVAWMNRE SLAETAATGR    50
    AVYWSRSRKK LWRKGEESGH AQQVHELRLD CDGDVILLKV HQNGGIACHT 100
    GRASCFYRRL DGTSQRAAWV TVDPVLKDPE LIYK 134
    Length:134
    Mass (Da):15,013
    Last modified:March 7, 2006 - v1
    Checksum:i4D5DACC40E478E89
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM167904 Genomic DNA. Translation: CAJ50930.1.
    RefSeqiWP_012418957.1. NC_010645.1.
    YP_787815.1. NC_010645.1.

    Genome annotation databases

    GeneIDi6267176.
    KEGGibav:BAV3320.
    PATRICi21132963. VBIBorAvi43433_3358.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM167904 Genomic DNA. Translation: CAJ50930.1 .
    RefSeqi WP_012418957.1. NC_010645.1.
    YP_787815.1. NC_010645.1.

    3D structure databases

    ProteinModelPortali Q2KTT0.
    SMRi Q2KTT0. Positions 14-112.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 360910.BAV3320.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 6267176.
    KEGGi bav:BAV3320.
    PATRICi 21132963. VBIBorAvi43433_3358.

    Phylogenomic databases

    eggNOGi COG0139.
    HOGENOMi HOG000277504.
    KOi K01496.
    OMAi HEPGIAC.
    OrthoDBi EOG6PGKB6.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00008 .
    BioCyci BAVI360910:GCKI-3397-MONOMER.

    Family and domain databases

    HAMAPi MF_01021. HisI.
    InterProi IPR026660. PRA-CH.
    IPR002496. PRib_AMP_CycHydrolase_dom.
    [Graphical view ]
    Pfami PF01502. PRA-CH. 1 hit.
    [Graphical view ]
    ProDomi PD002610. PRA_CycHdrlase. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparison of the genome sequence of the poultry pathogen Bordetella avium with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals extensive diversity in surface structures associated with host interaction."
      Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D., King N.D., Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D., Goble A., Lord A., Murphy L., Quail M.A., Rutter S., Squares R., Squares S., Woodward J., Parkhill J., Temple L.M.
      J. Bacteriol. 188:6002-6015(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 197N.

    Entry informationi

    Entry nameiHIS3_BORA1
    AccessioniPrimary (citable) accession number: Q2KTT0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3