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Protein

Catalase-peroxidase

Gene

katG

Organism
Bordetella avium (strain 197N)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei88 – 881Transition state stabilizerUniRule annotation
Active sitei92 – 921Proton acceptorUniRule annotation
Metal bindingi277 – 2771Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciBAVI360910:GCKI-3497-MONOMER.

Protein family/group databases

PeroxiBasei3418. BavCP01.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
Ordered Locus Names:BAV3417
OrganismiBordetella avium (strain 197N)
Taxonomic identifieri360910 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesAlcaligenaceaeBordetella
Proteomesi
  • UP000001977 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 748748Catalase-peroxidasePRO_0000354726Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki91 ↔ 236Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-262)UniRule annotation
Cross-linki236 ↔ 262Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-91)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi360910.BAV3417.

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OrthoDBiEOG6RRKKM.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2KTI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNEAKCPFN HTAGSGTTNQ DWWPKRLRLE LLSQHSAKTN PLDPDFDYAK
60 70 80 90 100
AFNSLDLAAV KQDLAKLMTD SQDWWPADFG HYGPLFIRMA WHSAGTYRVG
110 120 130 140 150
DGRGGAGRGQ QRFAPLNSWP DNVSLDKARR LLWPIKKKYG NKISWADLFI
160 170 180 190 200
LTGNVALETM GFKTFGFGGG REDTWEPDQD VYWGDEKTWL GGDLRYGKNE
210 220 230 240 250
AQPVADKAGH GKEHGRTDGG RNLENPLAAV QMGLIYVNPE GPDGNPDPQA
260 270 280 290 300
SAHDIRETFA RMAMNDEETV ALIAGGHTFG KTHGAGPADN VGPEPEAAEL
310 320 330 340 350
ENQGLGWKNS FGTGKGSDTI TSGLEVTWTS TPTKWSNNFF WNLFGYEWEL
360 370 380 390 400
TKSPAGAHQW IPKHGAGAGS VPDAHDPSKR HVPSMLTSDI ALRVDPAYEK
410 420 430 440 450
IARRFFENPD EFADAFARAW FKLTHRDMGP RVRYLGPEVP AEDLIWQDPI
460 470 480 490 500
PKVNHPLVDD QDVAALKQKV LASGLSVSEL VSTAWASAST FRGSDKRGGA
510 520 530 540 550
NGARIRLAPQ KDWAVNQPEQ LAKVLKVLEG IQADFNGKQS GGKKVSLADL
560 570 580 590 600
IVLAGCAAIE QAAGQAGHKV TVPFTAGRMD ASQEQTDVAS FAPLEPVHDG
610 620 630 640 650
FRNFLKSRYD VPAEHLLIDR AQLLTLTAPE MTVLIGGLRV LDVHTDKEKH
660 670 680 690 700
GVFTDRPGVL TNDFFRNLID MGTEWKPSSP ARESFTGHDR KTGKQKWTAS
710 720 730 740
RVDLVFGSNS QLRALSEVYA SDDAQDKFVR DFIAAWTKVM NLDRFDLK
Length:748
Mass (Da):82,411
Last modified:November 25, 2008 - v2
Checksum:i13D42B441D82CDB5
GO

Sequence cautioni

The sequence CAJ51027.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM167904 Genomic DNA. Translation: CAJ51027.1. Different initiation.
RefSeqiWP_039051346.1. NC_010645.1.

Genome annotation databases

EnsemblBacteriaiCAJ51027; CAJ51027; BAV3417.
KEGGibav:BAV3417.
PATRICi21133165. VBIBorAvi43433_3457.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM167904 Genomic DNA. Translation: CAJ51027.1. Different initiation.
RefSeqiWP_039051346.1. NC_010645.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi360910.BAV3417.

Protein family/group databases

PeroxiBasei3418. BavCP01.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAJ51027; CAJ51027; BAV3417.
KEGGibav:BAV3417.
PATRICi21133165. VBIBorAvi43433_3457.

Phylogenomic databases

eggNOGiENOG4105C1X. Bacteria.
COG0376. LUCA.
HOGENOMiHOG000218110.
KOiK03782.
OrthoDBiEOG6RRKKM.

Enzyme and pathway databases

BioCyciBAVI360910:GCKI-3497-MONOMER.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Comparison of the genome sequence of the poultry pathogen Bordetella avium with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals extensive diversity in surface structures associated with host interaction."
    Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D., King N.D., Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D., Goble A., Lord A., Murphy L., Quail M.A., Rutter S., Squares R., Squares S., Woodward J., Parkhill J., Temple L.M.
    J. Bacteriol. 188:6002-6015(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 197N.

Entry informationi

Entry nameiKATG_BORA1
AccessioniPrimary (citable) accession number: Q2KTI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: November 25, 2008
Last modified: December 9, 2015
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.