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Protein

DNA polymerase

Gene

pold1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotation

GO - Molecular functioni

GO - Biological processi

  • DNA replication Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymeraseUniRule annotation, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replicationUniRule annotation

Keywords - Ligandi

DNA-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymeraseUniRule annotation (EC:2.7.7.7UniRule annotation)
Gene namesi
Name:pold1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-060429-1. pold1.

PTM / Processingi

Proteomic databases

PaxDbiQ2KNE0.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000055858.

Structurei

3D structure databases

ProteinModelPortaliQ2KNE0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini124 – 481358DNA_pol_B_exo1InterPro annotationAdd
BLAST
Domaini539 – 977439DNA_pol_BInterPro annotationAdd
BLAST
Domaini1016 – 108671zf-C4polInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the DNA polymerase type-B family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0968. Eukaryota.
COG0417. LUCA.
HOVERGENiHBG051395.
KOiK02327.
PhylomeDBiQ2KNE0.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
3.90.1600.10. 2 hits.
InterProiIPR006172. DNA-dir_DNA_pol_B.
IPR017964. DNA-dir_DNA_pol_B_CS.
IPR006133. DNA-dir_DNA_pol_B_exonuc.
IPR006134. DNA-dir_DNA_pol_B_multi_dom.
IPR023211. DNA_pol_palm_dom.
IPR012337. RNaseH-like_dom.
IPR025687. Znf-C4pol.
[Graphical view]
PfamiPF00136. DNA_pol_B. 1 hit.
PF03104. DNA_pol_B_exo1. 1 hit.
PF14260. zf-C4pol. 1 hit.
[Graphical view]
PRINTSiPR00106. DNAPOLB.
SMARTiSM00486. POLBc. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
PROSITEiPS00116. DNA_POLYMERASE_B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2KNE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFKRRNGGP AMGGASQAKK GKPSTEWEDS PSQFEEELAL FDEMDMEVES
60 70 80 90 100
GEGQAGHDVI PVGDLFSTDL NPRWKRPHAS PLHPKSDTLI FQQIDLDYYL
110 120 130 140 150
GAAVAGMPGQ VQGKVPIVRM FGVTDNGNSV CCHIHGFAPY FYVPAPNGFT
160 170 180 190 200
NAHLAGFQRE LNSVVLKDMR SNKDNIAVTV LAVDITKKES MYNYHGNKPH
210 220 230 240 250
DFLRITMAMP RLVAPAKRLL EQGFKFANFA TQSYQAFEAN IDFEIRFMVD
260 270 280 290 300
SNVVGCCWIE LPKGKYQLRE ERREGQTDSK YPGKVSLCQY EVDVAWDSLI
310 320 330 340 350
SHPAEGEWQR IAPLRVLSFD IECAGRKGVF PEPEVDPVIQ IASMVQRQGE
360 370 380 390 400
KEPFIRTVFT LQSCASIVGS QILCFTQEKL MLQSWAEFMR TVDPDIITGY
410 420 430 440 450
NIQNFDLPYL LNRAATLKVN MFPYLGRVWG CKSVLKDSSF QSKQMGRREN
460 470 480 490 500
KTINMEGRVQ FDLLQVLLRD YKLRSYTLNA VSFHFLQEQK EDVQHSIITD
510 520 530 540 550
LQNGNEQTRR RLAVYCLKDA YLPLRLLQKL MCVINYMEMA RVTGVPLTYL
560 570 580 590 600
LSRGQQIKVV SQLLRQAMKQ DLVMPVVKTE GGEDYTGATV IEPEKGYYSV
610 620 630 640 650
PIATLDFSSL YPSIMMAHNL CYTTLLQKSQ IEKLGLGPDD FIKTPTGDLF
660 670 680 690 700
VKSSVRKGLL PEILENLLSA RKRAKAELKK ETDPFKKQVL DGRQLALKIS
710 720 730 740 750
ANSVYGFTGA QVGKLPCLEI SQSVTGFGRQ MIEQTKQLVE SRYTLDNGYQ
760 770 780 790 800
ADAKVIYGDT DSVMVKLGVA TVQEAMNQGK EAAEWVSSHF VPPIKLEFEK
810 820 830 840 850
VYYPYLLINK KRYAGLYFSS SAEHHDKMDC KGIETVRRDN CPLVANLINT
860 870 880 890 900
CLQNILIDRD PDGAVTHAKE VISDLLCNRI DISQLVITKE LTRTAQEYAG
910 920 930 940 950
KQAHVELAER MRKRDAGSAP NLGDRVPYVI IKAAKGVAAY MKSEDPIYVL
960 970 980 990 1000
ENNIPIDTQY YLEQQLSKPL LRIFEPILGE SKAESVLLKG DHTRCKTVLT
1010 1020 1030 1040 1050
SRVGGLMAFA QKRSTCIGCR AVLKTDVAVC DFCKKRESEL YQKEIAHLST
1060 1070 1080 1090 1100
LEEKFSRLWT QCQRCQGSLH EDVLCTSRDC PIFYMRKKVQ KDLDDQEKLV

SRFGW
Length:1,105
Mass (Da):124,950
Last modified:March 7, 2006 - v1
Checksum:i49A19363935A6C2E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY883095 mRNA. Translation: AAW80296.1.
RefSeqiNP_001034899.1. NM_001039810.2.
UniGeneiDr.49022.

Genome annotation databases

GeneIDi556456.
KEGGidre:556456.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY883095 mRNA. Translation: AAW80296.1.
RefSeqiNP_001034899.1. NM_001039810.2.
UniGeneiDr.49022.

3D structure databases

ProteinModelPortaliQ2KNE0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000055858.

Proteomic databases

PaxDbiQ2KNE0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi556456.
KEGGidre:556456.

Organism-specific databases

CTDi5424.
ZFINiZDB-GENE-060429-1. pold1.

Phylogenomic databases

eggNOGiKOG0968. Eukaryota.
COG0417. LUCA.
HOVERGENiHBG051395.
KOiK02327.
PhylomeDBiQ2KNE0.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
3.90.1600.10. 2 hits.
InterProiIPR006172. DNA-dir_DNA_pol_B.
IPR017964. DNA-dir_DNA_pol_B_CS.
IPR006133. DNA-dir_DNA_pol_B_exonuc.
IPR006134. DNA-dir_DNA_pol_B_multi_dom.
IPR023211. DNA_pol_palm_dom.
IPR012337. RNaseH-like_dom.
IPR025687. Znf-C4pol.
[Graphical view]
PfamiPF00136. DNA_pol_B. 1 hit.
PF03104. DNA_pol_B_exo1. 1 hit.
PF14260. zf-C4pol. 1 hit.
[Graphical view]
PRINTSiPR00106. DNAPOLB.
SMARTiSM00486. POLBc. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
PROSITEiPS00116. DNA_POLYMERASE_B. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ2KNE0_DANRE
AccessioniPrimary (citable) accession number: Q2KNE0
Entry historyi
Integrated into UniProtKB/TrEMBL: March 7, 2006
Last sequence update: March 7, 2006
Last modified: June 8, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.