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Q2KNB9

- HXK2_ORYSJ

UniProt

Q2KNB9 - HXK2_ORYSJ

Protein

Hexokinase-2

Gene

HXK2

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (07 Mar 2006)
      Previous versions | rss
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    Functioni

    Fructose and glucose phosphorylating enzyme.1 Publication

    Catalytic activityi

    ATP + D-hexose = ADP + D-hexose 6-phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi98 – 1036ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. hexokinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.1.1. 4460.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hexokinase-2 (EC:2.7.1.1)
    Alternative name(s):
    Hexokinase-3
    Gene namesi
    Name:HXK2
    Synonyms:HXK3
    Ordered Locus Names:Os05g0532600, LOC_Os05g45590
    ORF Names:OSJNBa0053E05.8
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 5

    Organism-specific databases

    GrameneiQ2KNB9.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 494494Hexokinase-2PRO_0000247565Add
    BLAST

    Expressioni

    Tissue specificityi

    Expressed in roots, leaves, flowers, immature seeds, endosperm and seed coat.1 Publication

    Developmental stagei

    Expressed during flower development until 15 days after flowering.1 Publication

    Inductioni

    By glucose or fructose treatment in leaves.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ2KNB9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini39 – 238200Hexokinase type-1Add
    BLAST
    Domaini246 – 484239Hexokinase type-2Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni168 – 19427Glucose-bindingSequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi4 – 1411Poly-AlaAdd
    BLAST

    Sequence similaritiesi

    Belongs to the hexokinase family.Curated
    Contains 1 hexokinase type-1 domain.Curated
    Contains 1 hexokinase type-2 domain.Curated

    Phylogenomic databases

    eggNOGiCOG5026.
    HOGENOMiHOG000162670.
    OMAiIVRWACA.

    Family and domain databases

    InterProiIPR001312. Hexokinase.
    IPR022673. Hexokinase_C.
    IPR022672. Hexokinase_N.
    [Graphical view]
    PANTHERiPTHR19443. PTHR19443. 1 hit.
    PfamiPF00349. Hexokinase_1. 1 hit.
    PF03727. Hexokinase_2. 1 hit.
    [Graphical view]
    PRINTSiPR00475. HEXOKINASE.

    Sequencei

    Sequence statusi: Complete.

    Q2KNB9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRKAAAAAVA AAAAVGVALL VRRQLREAKR WGRADAVLRE LEERCAAPPG    50
    RLRQVADAMA VEMHAGLASE GGSKLKMIIS YVDALPSGEE KGVFYALDLG 100
    GTNFRVLRVQ LGGKEGRVIK QEHDEISIPP HLMTGGSNEL FDFIASSLAK 150
    FVASEGEDFH LAEGRQRELG FTFSFPVKQT SIASGTLINW TKGFSIDETV 200
    GEDVVTELTK ALERQGLDMK VTALINDTIG TLAGGRYDDN DVIAAVILGT 250
    GTNAAYVERA NAIPKWHDLL PKSGDMVINM EWGNFRSSHL PLTEFDQALD 300
    AESLNPGEQV YEKLISGMYL GEIVRRVLLK MAEEASLFGD EVPPKLKIPF 350
    IIRTPYMSMM HCDRSPDLRT VGAKLKDILG VQNTSLKTRR LVVDVCDIVA 400
    KRAAHLAAAG IHGILKKLGR DVPNTDKQRT VIAVDGGLYE HYTIFAECVE 450
    STLRDMLGED VSSTIVIKLA KDGSGIGAAL LAAAHSQYRE AEEL 494
    Length:494
    Mass (Da):53,626
    Last modified:March 7, 2006 - v1
    Checksum:iCBD4744352238E0D
    GO

    Sequence cautioni

    The sequence AAT47078.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ116384 mRNA. Translation: AAZ93619.1.
    AY884166 mRNA. Translation: AAX68419.1.
    AC121365 Genomic DNA. Translation: AAT47078.1. Sequence problems.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ116384 mRNA. Translation: AAZ93619.1 .
    AY884166 mRNA. Translation: AAX68419.1 .
    AC121365 Genomic DNA. Translation: AAT47078.1 . Sequence problems.

    3D structure databases

    ProteinModelPortali Q2KNB9.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    Gramenei Q2KNB9.

    Phylogenomic databases

    eggNOGi COG5026.
    HOGENOMi HOG000162670.
    OMAi IVRWACA.

    Enzyme and pathway databases

    BRENDAi 2.7.1.1. 4460.

    Family and domain databases

    InterProi IPR001312. Hexokinase.
    IPR022673. Hexokinase_C.
    IPR022672. Hexokinase_N.
    [Graphical view ]
    PANTHERi PTHR19443. PTHR19443. 1 hit.
    Pfami PF00349. Hexokinase_1. 1 hit.
    PF03727. Hexokinase_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00475. HEXOKINASE.
    ProtoNeti Search...

    Publicationsi

    1. "Structure, expression, and functional analysis of the hexokinase gene family in rice (Oryza sativa L.)."
      Cho J.-I., Ryoo N., Ko S., Lee S.-K., Lee J., Jung K.-H., Lee Y.-H., Bhoo S.H., Winderickx J., An G., Hahn T.-R., Jeon J.-S.
      Planta 224:598-611(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION, NOMENCLATURE.
      Strain: cv. Jinmi.
    2. "The hexokinase gene family in rice."
      Wang Y.D., Cheng W., Wang X.S., Zhou X.J.
      Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Zhonghua 15.
      Tissue: Flower.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.

    Entry informationi

    Entry nameiHXK2_ORYSJ
    AccessioniPrimary (citable) accession number: Q2KNB9
    Secondary accession number(s): Q6I5H8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3