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Protein

Hexokinase-2

Gene

HXK2

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Fructose and glucose phosphorylating enzyme.1 Publication

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi98 – 103ATPSequence analysis6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.1. 4460.

Names & Taxonomyi

Protein namesi
Recommended name:
Hexokinase-2 (EC:2.7.1.1)
Alternative name(s):
Hexokinase-3
Gene namesi
Name:HXK2
Synonyms:HXK3
Ordered Locus Names:Os05g0532600, LOC_Os05g45590
ORF Names:OSJNBa0053E05.8
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002475651 – 494Hexokinase-2Add BLAST494

Proteomic databases

PaxDbiQ2KNB9.
PRIDEiQ2KNB9.

Expressioni

Tissue specificityi

Expressed in roots, leaves, flowers, immature seeds, endosperm and seed coat.1 Publication

Developmental stagei

Expressed during flower development until 15 days after flowering.1 Publication

Inductioni

By glucose or fructose treatment in leaves.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os05g45590.1.

Structurei

3D structure databases

ProteinModelPortaliQ2KNB9.
SMRiQ2KNB9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 483HexokinasePROSITE-ProRule annotationAdd BLAST452

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni87 – 225Hexokinase small subdomainPROSITE-ProRule annotationAdd BLAST139
Regioni168 – 194Glucose-bindingSequence analysisAdd BLAST27
Regioni226 – 472Hexokinase large subdomainPROSITE-ProRule annotationAdd BLAST247

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 14Poly-AlaAdd BLAST11

Sequence similaritiesi

Belongs to the hexokinase family.PROSITE-ProRule annotationCurated

Phylogenomic databases

eggNOGiKOG1369. Eukaryota.
COG5026. LUCA.
HOGENOMiHOG000162670.
InParanoidiQ2KNB9.
KOiK00844.

Family and domain databases

InterProiView protein in InterPro
IPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiView protein in Pfam
PF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
PROSITEiView protein in PROSITE
PS51748. HEXOKINASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2KNB9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKAAAAAVA AAAAVGVALL VRRQLREAKR WGRADAVLRE LEERCAAPPG
60 70 80 90 100
RLRQVADAMA VEMHAGLASE GGSKLKMIIS YVDALPSGEE KGVFYALDLG
110 120 130 140 150
GTNFRVLRVQ LGGKEGRVIK QEHDEISIPP HLMTGGSNEL FDFIASSLAK
160 170 180 190 200
FVASEGEDFH LAEGRQRELG FTFSFPVKQT SIASGTLINW TKGFSIDETV
210 220 230 240 250
GEDVVTELTK ALERQGLDMK VTALINDTIG TLAGGRYDDN DVIAAVILGT
260 270 280 290 300
GTNAAYVERA NAIPKWHDLL PKSGDMVINM EWGNFRSSHL PLTEFDQALD
310 320 330 340 350
AESLNPGEQV YEKLISGMYL GEIVRRVLLK MAEEASLFGD EVPPKLKIPF
360 370 380 390 400
IIRTPYMSMM HCDRSPDLRT VGAKLKDILG VQNTSLKTRR LVVDVCDIVA
410 420 430 440 450
KRAAHLAAAG IHGILKKLGR DVPNTDKQRT VIAVDGGLYE HYTIFAECVE
460 470 480 490
STLRDMLGED VSSTIVIKLA KDGSGIGAAL LAAAHSQYRE AEEL
Length:494
Mass (Da):53,626
Last modified:March 7, 2006 - v1
Checksum:iCBD4744352238E0D
GO

Sequence cautioni

The sequence AAT47078 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ116384 mRNA. Translation: AAZ93619.1.
AY884166 mRNA. Translation: AAX68419.1.
AC121365 Genomic DNA. Translation: AAT47078.1. Sequence problems.
AP014961 Genomic DNA. No translation available.
RefSeqiXP_015637797.1. XM_015782311.1.
UniGeneiOs.17535.

Genome annotation databases

GeneIDi4339420.
KEGGiosa:4339420.

Similar proteinsi

Entry informationi

Entry nameiHXK2_ORYSJ
AccessioniPrimary (citable) accession number: Q2KNB9
Secondary accession number(s): Q6I5H8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 7, 2006
Last modified: August 30, 2017
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families