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Q2KNB9 (HXK2_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hexokinase-2

EC=2.7.1.1
Alternative name(s):
Hexokinase-3
Gene names
Name:HXK2
Synonyms:HXK3
Ordered Locus Names:Os05g0532600, LOC_Os05g45590
ORF Names:OSJNBa0053E05.8
OrganismOryza sativa subsp. japonica (Rice) [Reference proteome]
Taxonomic identifier39947 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza

Protein attributes

Sequence length494 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Fructose and glucose phosphorylating enzyme. Ref.1

Catalytic activity

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Tissue specificity

Expressed in roots, leaves, flowers, immature seeds, endosperm and seed coat. Ref.1

Developmental stage

Expressed during flower development until 15 days after flowering. Ref.1

Induction

By glucose or fructose treatment in leaves. Ref.1

Sequence similarities

Belongs to the hexokinase family.

Contains 1 hexokinase type-1 domain.

Contains 1 hexokinase type-2 domain.

Sequence caution

The sequence AAT47078.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Biological processGlycolysis
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processglycolytic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

hexokinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 494494Hexokinase-2
PRO_0000247565

Regions

Domain39 – 238200Hexokinase type-1
Domain246 – 484239Hexokinase type-2
Nucleotide binding98 – 1036ATP Potential
Region168 – 19427Glucose-binding Potential
Compositional bias4 – 1411Poly-Ala

Sequences

Sequence LengthMass (Da)Tools
Q2KNB9 [UniParc].

Last modified March 7, 2006. Version 1.
Checksum: CBD4744352238E0D

FASTA49453,626
        10         20         30         40         50         60 
MRKAAAAAVA AAAAVGVALL VRRQLREAKR WGRADAVLRE LEERCAAPPG RLRQVADAMA 

        70         80         90        100        110        120 
VEMHAGLASE GGSKLKMIIS YVDALPSGEE KGVFYALDLG GTNFRVLRVQ LGGKEGRVIK 

       130        140        150        160        170        180 
QEHDEISIPP HLMTGGSNEL FDFIASSLAK FVASEGEDFH LAEGRQRELG FTFSFPVKQT 

       190        200        210        220        230        240 
SIASGTLINW TKGFSIDETV GEDVVTELTK ALERQGLDMK VTALINDTIG TLAGGRYDDN 

       250        260        270        280        290        300 
DVIAAVILGT GTNAAYVERA NAIPKWHDLL PKSGDMVINM EWGNFRSSHL PLTEFDQALD 

       310        320        330        340        350        360 
AESLNPGEQV YEKLISGMYL GEIVRRVLLK MAEEASLFGD EVPPKLKIPF IIRTPYMSMM 

       370        380        390        400        410        420 
HCDRSPDLRT VGAKLKDILG VQNTSLKTRR LVVDVCDIVA KRAAHLAAAG IHGILKKLGR 

       430        440        450        460        470        480 
DVPNTDKQRT VIAVDGGLYE HYTIFAECVE STLRDMLGED VSSTIVIKLA KDGSGIGAAL 

       490 
LAAAHSQYRE AEEL 

« Hide

References

« Hide 'large scale' references
[1]"Structure, expression, and functional analysis of the hexokinase gene family in rice (Oryza sativa L.)."
Cho J.-I., Ryoo N., Ko S., Lee S.-K., Lee J., Jung K.-H., Lee Y.-H., Bhoo S.H., Winderickx J., An G., Hahn T.-R., Jeon J.-S.
Planta 224:598-611(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION, NOMENCLATURE.
Strain: cv. Jinmi.
[2]"The hexokinase gene family in rice."
Wang Y.D., Cheng W., Wang X.S., Zhou X.J.
Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. Zhonghua 15.
Tissue: Flower.
[3]"A fine physical map of the rice chromosome 5."
Cheng C.-H., Chung M.C., Liu S.-M., Chen S.-K., Kao F.Y., Lin S.-J., Hsiao S.-H., Tseng I.C., Hsing Y.-I.C., Wu H.-P., Chen C.-S., Shaw J.-F., Wu J., Matsumoto T., Sasaki T., Chen H.-C., Chow T.-Y.
Mol. Genet. Genomics 274:337-345(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Nipponbare.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ116384 mRNA. Translation: AAZ93619.1.
AY884166 mRNA. Translation: AAX68419.1.
AC121365 Genomic DNA. Translation: AAT47078.1. Sequence problems.

3D structure databases

ProteinModelPortalQ2KNB9.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GrameneQ2KNB9.

Phylogenomic databases

eggNOGCOG5026.
HOGENOMHOG000162670.
OMAIVRWACA.

Enzyme and pathway databases

BRENDA2.7.1.1. 4460.

Family and domain databases

InterProIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERPTHR19443. PTHR19443. 1 hit.
PfamPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSPR00475. HEXOKINASE.
ProtoNetSearch...

Entry information

Entry nameHXK2_ORYSJ
AccessionPrimary (citable) accession number: Q2KNB9
Secondary accession number(s): Q6I5H8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 7, 2006
Last modified: June 11, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Oryza sativa (rice)

Index of Oryza sativa entries and their corresponding gene designations