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Protein

Hexokinase-2

Gene

HXK2

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Fructose and glucose phosphorylating enzyme.1 Publication

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi98 – 1036ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. hexokinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.1. 4460.

Names & Taxonomyi

Protein namesi
Recommended name:
Hexokinase-2 (EC:2.7.1.1)
Alternative name(s):
Hexokinase-3
Gene namesi
Name:HXK2
Synonyms:HXK3
Ordered Locus Names:Os05g0532600, LOC_Os05g45590
ORF Names:OSJNBa0053E05.8
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 5

Organism-specific databases

GrameneiQ2KNB9.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 494494Hexokinase-2PRO_0000247565Add
BLAST

Expressioni

Tissue specificityi

Expressed in roots, leaves, flowers, immature seeds, endosperm and seed coat.1 Publication

Developmental stagei

Expressed during flower development until 15 days after flowering.1 Publication

Inductioni

By glucose or fructose treatment in leaves.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ2KNB9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 238200Hexokinase type-1Add
BLAST
Domaini246 – 484239Hexokinase type-2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni168 – 19427Glucose-bindingSequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi4 – 1411Poly-AlaAdd
BLAST

Sequence similaritiesi

Belongs to the hexokinase family.Curated
Contains 1 hexokinase type-1 domain.Curated
Contains 1 hexokinase type-2 domain.Curated

Phylogenomic databases

eggNOGiCOG5026.
HOGENOMiHOG000162670.
InParanoidiQ2KNB9.
OMAiHALDNES.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.

Sequencei

Sequence statusi: Complete.

Q2KNB9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKAAAAAVA AAAAVGVALL VRRQLREAKR WGRADAVLRE LEERCAAPPG
60 70 80 90 100
RLRQVADAMA VEMHAGLASE GGSKLKMIIS YVDALPSGEE KGVFYALDLG
110 120 130 140 150
GTNFRVLRVQ LGGKEGRVIK QEHDEISIPP HLMTGGSNEL FDFIASSLAK
160 170 180 190 200
FVASEGEDFH LAEGRQRELG FTFSFPVKQT SIASGTLINW TKGFSIDETV
210 220 230 240 250
GEDVVTELTK ALERQGLDMK VTALINDTIG TLAGGRYDDN DVIAAVILGT
260 270 280 290 300
GTNAAYVERA NAIPKWHDLL PKSGDMVINM EWGNFRSSHL PLTEFDQALD
310 320 330 340 350
AESLNPGEQV YEKLISGMYL GEIVRRVLLK MAEEASLFGD EVPPKLKIPF
360 370 380 390 400
IIRTPYMSMM HCDRSPDLRT VGAKLKDILG VQNTSLKTRR LVVDVCDIVA
410 420 430 440 450
KRAAHLAAAG IHGILKKLGR DVPNTDKQRT VIAVDGGLYE HYTIFAECVE
460 470 480 490
STLRDMLGED VSSTIVIKLA KDGSGIGAAL LAAAHSQYRE AEEL
Length:494
Mass (Da):53,626
Last modified:March 7, 2006 - v1
Checksum:iCBD4744352238E0D
GO

Sequence cautioni

The sequence AAT47078.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ116384 mRNA. Translation: AAZ93619.1.
AY884166 mRNA. Translation: AAX68419.1.
AC121365 Genomic DNA. Translation: AAT47078.1. Sequence problems.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ116384 mRNA. Translation: AAZ93619.1.
AY884166 mRNA. Translation: AAX68419.1.
AC121365 Genomic DNA. Translation: AAT47078.1. Sequence problems.

3D structure databases

ProteinModelPortaliQ2KNB9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GrameneiQ2KNB9.

Phylogenomic databases

eggNOGiCOG5026.
HOGENOMiHOG000162670.
InParanoidiQ2KNB9.
OMAiHALDNES.

Enzyme and pathway databases

BRENDAi2.7.1.1. 4460.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure, expression, and functional analysis of the hexokinase gene family in rice (Oryza sativa L.)."
    Cho J.-I., Ryoo N., Ko S., Lee S.-K., Lee J., Jung K.-H., Lee Y.-H., Bhoo S.H., Winderickx J., An G., Hahn T.-R., Jeon J.-S.
    Planta 224:598-611(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION, NOMENCLATURE.
    Strain: cv. Jinmi.
  2. "The hexokinase gene family in rice."
    Wang Y.D., Cheng W., Wang X.S., Zhou X.J.
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Zhonghua 15.
    Tissue: Flower.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.

Entry informationi

Entry nameiHXK2_ORYSJ
AccessioniPrimary (citable) accession number: Q2KNB9
Secondary accession number(s): Q6I5H8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 7, 2006
Last modified: January 7, 2015
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.