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Q2KNB4

- HXK3_ORYSJ

UniProt

Q2KNB4 - HXK3_ORYSJ

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Protein

Hexokinase-3

Gene

HXK3

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Fructose and glucose phosphorylating enzyme. May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol (By similarity).By similarity

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi101 – 1066ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. hexokinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_252558. Regulation of Glucokinase by Glucokinase Regulatory Protein.
REACT_255428. Regulation of gene expression in beta cells.
REACT_261692. Glucose transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Hexokinase-3 (EC:2.7.1.1)
Alternative name(s):
Hexokinase-8
Gene namesi
Name:HXK3
Synonyms:HXK8
Ordered Locus Names:Os01g0940100, LOC_Os01g71320
ORF Names:B1150F11.26-1
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 1

Organism-specific databases

GrameneiQ2KNB4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4 – 2421HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial outer membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 500500Hexokinase-3PRO_0000247566Add
BLAST

Expressioni

Tissue specificityi

Expressed in roots, leaves, flowers, immature seeds and seed coat.1 Publication

Developmental stagei

Expressed during flower development until 8 days after flowering.1 Publication

Inductioni

Not induced by glucose or fructose treatment in leaves.1 Publication

Gene expression databases

ExpressionAtlasiQ2KNB4. baseline.

Structurei

3D structure databases

ProteinModelPortaliQ2KNB4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 234194Hexokinase type-1Add
BLAST
Domaini241 – 489249Hexokinase type-2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni165 – 19127Glucose-bindingSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the hexokinase family.Curated
Contains 1 hexokinase type-1 domain.Curated
Contains 1 hexokinase type-2 domain.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5026.
HOGENOMiHOG000162670.
InParanoidiQ2KNB4.
OMAiRWTKGFL.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2KNB4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGRVGLGVAV GCAAVTCAIA AALVARRASA RARWRRAVAL LREFEEGCAT
60 70 80 90 100
PPARLRQVVD AMVVEMHAGL ASDGGSKLKM LLTFVDALPS GSEEGVYYSI
110 120 130 140 150
DLGGTNFRVL RVQVGAGSVI VNQKVEQQPI PEELTKGTTE GLFNFVALAL
160 170 180 190 200
KNFLEGEDDQ DGKMALGFTF SFPVRQISVS SGSLIRWTKG FSIRDTVGRD
210 220 230 240 250
VAQCLNEALA NCGLNVRVTA LVNDTVGTLA LGHYYDEDTV AAVIIGSGTN
260 270 280 290 300
ACYIERTDAI IKCQGLLTNS GGMVVNMEWG NFWSSHLPRT PYDILLDDET
310 320 330 340 350
HNRNDQGFEK MISGMYLGEI ARLVFHRMAQ ESDVFGDAAD SLSNPFILST
360 370 380 390 400
PFLAAIREDD SPDLSEVRRI LREHLKIPDA PLKTRRLVVK VCDIVTRRAA
410 420 430 440 450
RLAAAGIVGI LKKLGRDGSG AASSGRGRGQ PRRTVVAIEG GLYQGYPVFR
460 470 480 490 500
EYLDEALVEI LGEEVARNVT LRVTEDGSGV GAALLAAVHS SNRQQQGGPI
Length:500
Mass (Da):53,794
Last modified:March 7, 2006 - v1
Checksum:i0179231A6AC47A2C
GO

Sequence cautioni

The sequence BAD87613.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ116385 mRNA. Translation: AAZ93620.1.
AY884171 mRNA. Translation: AAX68424.1.
AP003412 Genomic DNA. Translation: BAD87613.1. Sequence problems.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ116385 mRNA. Translation: AAZ93620.1 .
AY884171 mRNA. Translation: AAX68424.1 .
AP003412 Genomic DNA. Translation: BAD87613.1 . Sequence problems.

3D structure databases

ProteinModelPortali Q2KNB4.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

Gramenei Q2KNB4.

Phylogenomic databases

eggNOGi COG5026.
HOGENOMi HOG000162670.
InParanoidi Q2KNB4.
OMAi RWTKGFL.

Enzyme and pathway databases

Reactomei REACT_252558. Regulation of Glucokinase by Glucokinase Regulatory Protein.
REACT_255428. Regulation of gene expression in beta cells.
REACT_261692. Glucose transport.

Gene expression databases

ExpressionAtlasi Q2KNB4. baseline.

Family and domain databases

InterProi IPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view ]
PANTHERi PTHR19443. PTHR19443. 1 hit.
Pfami PF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view ]
PRINTSi PR00475. HEXOKINASE.
PROSITEi PS00378. HEXOKINASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure, expression, and functional analysis of the hexokinase gene family in rice (Oryza sativa L.)."
    Cho J.-I., Ryoo N., Ko S., Lee S.-K., Lee J., Jung K.-H., Lee Y.-H., Bhoo S.H., Winderickx J., An G., Hahn T.-R., Jeon J.-S.
    Planta 224:598-611(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION, NOMENCLATURE.
    Strain: cv. Jinmi.
  2. "The hexokinase gene family in rice."
    Wang Y.D., Cheng W., Wang X.S., Zhou X.J.
    Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. Zhonghua 15.
    Tissue: Flower.
  3. "The genome sequence and structure of rice chromosome 1."
    Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y., Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H., Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M.
    , Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M., Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T., Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S., Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H., Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y., Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S., Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y., Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S., Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H., Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T.
    Nature 420:312-316(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.

Entry informationi

Entry nameiHXK3_ORYSJ
AccessioniPrimary (citable) accession number: Q2KNB4
Secondary accession number(s): Q5JLP7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 7, 2006
Last modified: November 26, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3