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Q2KNB4

- HXK3_ORYSJ

UniProt

Q2KNB4 - HXK3_ORYSJ

Protein

Hexokinase-3

Gene

HXK3

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (07 Mar 2006)
      Previous versions | rss
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    Functioni

    Fructose and glucose phosphorylating enzyme. May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol By similarity.By similarity

    Catalytic activityi

    ATP + D-hexose = ADP + D-hexose 6-phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi101 – 1066ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. hexokinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW
    2. response to cold Source: EnsemblPlants/Gramene
    3. response to salt stress Source: EnsemblPlants/Gramene
    4. root hair cell development Source: EnsemblPlants/Gramene

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hexokinase-3 (EC:2.7.1.1)
    Alternative name(s):
    Hexokinase-8
    Gene namesi
    Name:HXK3
    Synonyms:HXK8
    Ordered Locus Names:Os01g0940100, LOC_Os01g71320
    ORF Names:B1150F11.26-1
    OrganismiOryza sativa subsp. japonica (Rice)
    Taxonomic identifieri39947 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
    ProteomesiUP000000763: Chromosome 1

    Organism-specific databases

    GrameneiQ2KNB4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of mitochondrial outer membrane Source: EnsemblPlants/Gramene
    2. plastid Source: EnsemblPlants/Gramene

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion outer membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 500500Hexokinase-3PRO_0000247566Add
    BLAST

    Expressioni

    Tissue specificityi

    Expressed in roots, leaves, flowers, immature seeds and seed coat.1 Publication

    Developmental stagei

    Expressed during flower development until 8 days after flowering.1 Publication

    Inductioni

    Not induced by glucose or fructose treatment in leaves.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ2KNB4.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei4 – 2421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini41 – 234194Hexokinase type-1Add
    BLAST
    Domaini241 – 489249Hexokinase type-2Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni165 – 19127Glucose-bindingSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the hexokinase family.Curated
    Contains 1 hexokinase type-1 domain.Curated
    Contains 1 hexokinase type-2 domain.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5026.
    HOGENOMiHOG000162670.
    OMAiRWTKGFL.

    Family and domain databases

    InterProiIPR001312. Hexokinase.
    IPR022673. Hexokinase_C.
    IPR019807. Hexokinase_CS.
    IPR022672. Hexokinase_N.
    [Graphical view]
    PANTHERiPTHR19443. PTHR19443. 1 hit.
    PfamiPF00349. Hexokinase_1. 1 hit.
    PF03727. Hexokinase_2. 1 hit.
    [Graphical view]
    PRINTSiPR00475. HEXOKINASE.
    PROSITEiPS00378. HEXOKINASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q2KNB4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGRVGLGVAV GCAAVTCAIA AALVARRASA RARWRRAVAL LREFEEGCAT    50
    PPARLRQVVD AMVVEMHAGL ASDGGSKLKM LLTFVDALPS GSEEGVYYSI 100
    DLGGTNFRVL RVQVGAGSVI VNQKVEQQPI PEELTKGTTE GLFNFVALAL 150
    KNFLEGEDDQ DGKMALGFTF SFPVRQISVS SGSLIRWTKG FSIRDTVGRD 200
    VAQCLNEALA NCGLNVRVTA LVNDTVGTLA LGHYYDEDTV AAVIIGSGTN 250
    ACYIERTDAI IKCQGLLTNS GGMVVNMEWG NFWSSHLPRT PYDILLDDET 300
    HNRNDQGFEK MISGMYLGEI ARLVFHRMAQ ESDVFGDAAD SLSNPFILST 350
    PFLAAIREDD SPDLSEVRRI LREHLKIPDA PLKTRRLVVK VCDIVTRRAA 400
    RLAAAGIVGI LKKLGRDGSG AASSGRGRGQ PRRTVVAIEG GLYQGYPVFR 450
    EYLDEALVEI LGEEVARNVT LRVTEDGSGV GAALLAAVHS SNRQQQGGPI 500
    Length:500
    Mass (Da):53,794
    Last modified:March 7, 2006 - v1
    Checksum:i0179231A6AC47A2C
    GO

    Sequence cautioni

    The sequence BAD87613.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ116385 mRNA. Translation: AAZ93620.1.
    AY884171 mRNA. Translation: AAX68424.1.
    AP003412 Genomic DNA. Translation: BAD87613.1. Sequence problems.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ116385 mRNA. Translation: AAZ93620.1 .
    AY884171 mRNA. Translation: AAX68424.1 .
    AP003412 Genomic DNA. Translation: BAD87613.1 . Sequence problems.

    3D structure databases

    ProteinModelPortali Q2KNB4.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    Gramenei Q2KNB4.

    Phylogenomic databases

    eggNOGi COG5026.
    HOGENOMi HOG000162670.
    OMAi RWTKGFL.

    Family and domain databases

    InterProi IPR001312. Hexokinase.
    IPR022673. Hexokinase_C.
    IPR019807. Hexokinase_CS.
    IPR022672. Hexokinase_N.
    [Graphical view ]
    PANTHERi PTHR19443. PTHR19443. 1 hit.
    Pfami PF00349. Hexokinase_1. 1 hit.
    PF03727. Hexokinase_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00475. HEXOKINASE.
    PROSITEi PS00378. HEXOKINASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure, expression, and functional analysis of the hexokinase gene family in rice (Oryza sativa L.)."
      Cho J.-I., Ryoo N., Ko S., Lee S.-K., Lee J., Jung K.-H., Lee Y.-H., Bhoo S.H., Winderickx J., An G., Hahn T.-R., Jeon J.-S.
      Planta 224:598-611(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INDUCTION, NOMENCLATURE.
      Strain: cv. Jinmi.
    2. "The hexokinase gene family in rice."
      Wang Y.D., Cheng W., Wang X.S., Zhou X.J.
      Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. Zhonghua 15.
      Tissue: Flower.
    3. "The genome sequence and structure of rice chromosome 1."
      Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y., Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H., Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M.
      , Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M., Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T., Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S., Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H., Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y., Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S., Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y., Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S., Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H., Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T.
      Nature 420:312-316(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Nipponbare.

    Entry informationi

    Entry nameiHXK3_ORYSJ
    AccessioniPrimary (citable) accession number: Q2KNB4
    Secondary accession number(s): Q5JLP7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: March 7, 2006
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Oryza sativa (rice)
      Index of Oryza sativa entries and their corresponding gene designations
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3