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Protein

Cytospin-A

Gene

Specc1l

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Cytospin-A
Alternative name(s):
SPECC1-like protein
Sperm antigen with calponin homology and coiled-coil domains 1-like
Gene namesi
Name:Specc1l
Synonyms:Cytsa
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi1309570. Specc1l.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Gap junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002310211 – 1118Cytospin-AAdd BLAST1118

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei385PhosphoserineBy similarity1
Modified residuei386PhosphoserineBy similarity1
Modified residuei390PhosphoserineBy similarity1
Modified residuei869PhosphoserineBy similarity1
Modified residuei882PhosphoserineBy similarity1
Modified residuei888PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ2KN99.
PRIDEiQ2KN99.

PTM databases

iPTMnetiQ2KN99.
PhosphoSitePlusiQ2KN99.

Expressioni

Gene expression databases

BgeeiENSRNOG00000001303.
GenevisibleiQ2KN99. RN.

Interactioni

Subunit structurei

May interact with both microtubules and actin cytoskeleton.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001764.

Structurei

3D structure databases

ProteinModelPortaliQ2KN99.
SMRiQ2KN99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1012 – 1117Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST106

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili168 – 281Sequence analysisAdd BLAST114
Coiled coili395 – 450Sequence analysisAdd BLAST56
Coiled coili488 – 808Sequence analysisAdd BLAST321

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi45 – 48Poly-Ala4
Compositional biasi858 – 862Poly-Ala5

Sequence similaritiesi

Belongs to the cytospin-A family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4678. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00760000118856.
HOGENOMiHOG000015307.
HOVERGENiHBG056096.
InParanoidiQ2KN99.
OMAiERPDWQN.
OrthoDBiEOG091G01BX.
PhylomeDBiQ2KN99.

Family and domain databases

CDDicd00014. CH. 1 hit.
Gene3Di1.10.418.10. 1 hit.
InterProiView protein in InterPro
IPR001715. CH-domain.
IPR036872. CH_dom_sf.
PfamiView protein in Pfam
PF00307. CH. 1 hit.
SMARTiView protein in SMART
SM00033. CH. 1 hit.
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiView protein in PROSITE
PS50021. CH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2KN99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKANRSAGS VPKVSGISKP QTVEKSKSEN SSSAPTGGKP VKPGAAAALS
60 70 80 90 100
KTKSNDDLLA GMAGGVNVTN GVKAKKSNCS SAAPSAPAPA MTISESKSKS
110 120 130 140 150
STGTSSSAKR STSAGNKESS STRERLRERT RLNQSKKLPS VSQGANDVAL
160 170 180 190 200
AKRSRSRTAT EGDIRMSKSK SDNQISDKAA LEAKVKDLLT LAKTKDVEIL
210 220 230 240 250
HLRNELRDMR AQLGISEDHC EGEDRSEEKE TIIAHQPTDV ESTLLQLQEQ
260 270 280 290 300
NTAIREELNQ LKNENRMLKD RLNALGFSLE QRLDNSEKLF GYQSLSPEIT
310 320 330 340 350
PGNQSDGGGT LTSSVEGSAP GSVEDLLSQD ENTLMAHQHS NSMDNLDSEC
360 370 380 390 400
SEVYQPLTSS DDALDAPSSS ESEGVPSIER SRKGSSGNAS EVSVACLTER
410 420 430 440 450
IHQMEENQHS TSEELQATLQ ELADLQQITQ ELNSENERLG EEKVILMESL
460 470 480 490 500
CQQSDKLEHF GRQIEYFRSL LDEHHISYVI DEDVKSGRYM ELEQRYMDLA
510 520 530 540 550
ENARFEREQL LGVQQHLSNT LKMAEQDNKE AQEMIGALKE RSHHMERIIE
560 570 580 590 600
SEQKGKAALA ATLEEYKATV ASDQIEMNRL KAQLEKEKQK VAELYSIHNS
610 620 630 640 650
GDKSDIQDLL ESVRLDKEKA ETLASSLQED LAHTRNDANR LQDTIAKVED
660 670 680 690 700
EYRAFQEEAK KQIEDLNMTL EKLRSELEEK ETERSDMKET IFELEDEVEQ
710 720 730 740 750
HRAVKLHDNL IISDLENTVK KLQDQKHDLE RENKTLHRRL REESAEWRQF
760 770 780 790 800
QADLQTAVVI ANDIKSEAQE EIGDLKRRLH EAQEKNEKLT KELEEIKSRK
810 820 830 840 850
QEEERGRVYN YMNAVERDLA ALRQGMGLSR RSSTSSEPTP TVKTLIKSFD
860 870 880 890 900
SASQVPNAAA AAIPRTPLSP SPMKTPPAAA VSPMQRHSIS GPVSTSKPLT
910 920 930 940 950
ALSDKRSNYG EIPGQEHLLR TSSTSRPASL PRVPAMESAK TISVSRRSSE
960 970 980 990 1000
EMKRDISASE GASPASLMAM GTTSPQLSLS SSPTASVTPS TRSRIREERK
1010 1020 1030 1040 1050
DPLSALAREY GGSKRNALLK WCQKKTEGYQ NIDITNFSSS WNDGLAFCAL
1060 1070 1080 1090 1100
LHTYLPAHIP YQELNSQEKK RNFTLAFQAA ESVGIKSTLD INEMARTERP
1110
DWQNVMLYVT AIYKYFET
Length:1,118
Mass (Da):124,338
Last modified:March 7, 2006 - v1
Checksum:i063B4292C684D817
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY884296 mRNA. Translation: AAX84187.1.
RefSeqiNP_001034544.1. NM_001039455.1.
XP_006256401.1. XM_006256339.3.
UniGeneiRn.63017.

Genome annotation databases

EnsembliENSRNOT00000001764; ENSRNOP00000001764; ENSRNOG00000001303.
GeneIDi361828.
KEGGirno:361828.
UCSCiRGD:1309570. rat.

Similar proteinsi

Entry informationi

Entry nameiCYTSA_RAT
AccessioniPrimary (citable) accession number: Q2KN99
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: March 7, 2006
Last modified: March 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome