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Protein

Cytospin-A

Gene

Specc1l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration (By similarity).By similarity

GO - Biological processi

  • actin cytoskeleton organization Source: MGI
  • cell adhesion Source: MGI
  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • cell migration Source: MGI
  • face morphogenesis Source: MGI
  • negative regulation of actin filament depolymerization Source: MGI
  • negative regulation of microtubule depolymerization Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Cytospin-A
Alternative name(s):
SPECC1-like protein
Sperm antigen with calponin homology and coiled-coil domains 1-like
Gene namesi
Name:Specc1l
Synonyms:Cytsa, Kiaa0376
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1921642. Specc1l.

Subcellular locationi

GO - Cellular componenti

  • actin cytoskeleton Source: MGI
  • cytoplasm Source: UniProtKB-KW
  • filamentous actin Source: MGI
  • gap junction Source: UniProtKB-SubCell
  • microtubule cytoskeleton Source: MGI
  • microtubule organizing center Source: MGI
  • spindle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Gap junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11181118Cytospin-APRO_0000231019Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei385 – 3851PhosphoserineCombined sources
Modified residuei386 – 3861PhosphoserineCombined sources
Modified residuei390 – 3901PhosphoserineCombined sources
Modified residuei869 – 8691PhosphoserineBy similarity
Modified residuei882 – 8821PhosphoserineBy similarity
Modified residuei888 – 8881PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ2KN98.
PaxDbiQ2KN98.
PeptideAtlasiQ2KN98.
PRIDEiQ2KN98.

PTM databases

iPTMnetiQ2KN98.
PhosphoSiteiQ2KN98.

Expressioni

Developmental stagei

At 9.5-10.5 dpc, expressed in the developing maxillary prominence and the lateral nasal process, as well as in the limbs and eye.1 Publication

Gene expression databases

BgeeiENSMUSG00000033444.
CleanExiMM_SPECC1L.
GenevisibleiQ2KN98. MM.

Interactioni

Subunit structurei

May interact with both microtubules and actin cytoskeleton.

Protein-protein interaction databases

IntActiQ2KN98. 1 interaction.
STRINGi10090.ENSMUSP00000045099.

Structurei

3D structure databases

ProteinModelPortaliQ2KN98.
SMRiQ2KN98. Positions 1015-1114.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1012 – 1114103CHPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili168 – 281114Sequence analysisAdd
BLAST
Coiled coili395 – 45056Sequence analysisAdd
BLAST
Coiled coili488 – 808321Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi45 – 484Poly-Ala
Compositional biasi858 – 8625Poly-Ala

Sequence similaritiesi

Belongs to the cytospin-A family.Curated
Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4678. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00760000118856.
HOGENOMiHOG000015307.
HOVERGENiHBG056096.
InParanoidiQ2KN98.
PhylomeDBiQ2KN98.
TreeFamiTF316716.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
InterProiIPR001715. CH-domain.
[Graphical view]
PfamiPF00307. CH. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiPS50021. CH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2KN98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKANRSAGS VPKVSGISKP QTVEKSKPEN SSSAPTGVKP VRPGAAAALS
60 70 80 90 100
KTKSNDDLLA GMAGGVNVTN GIKAKKSTCS SAAPSAPAPA MTISENKSKI
110 120 130 140 150
STGTSSSAKR STSAGNKESS STRERLRERT RLNQSKKLPS VSQGANDVAL
160 170 180 190 200
AKRSRSRTAA EGDIRMSKSK SDNQISDKAA LEAKVKDLLT LAKTKDVEIL
210 220 230 240 250
HLRNELRDMR AQLGISEDHC EGEDRSEVKE TIIAHQPTDV ESTLLQLQEQ
260 270 280 290 300
NTAIREELNQ LKNENRMLKD RLNALGFSLE QRLDNSEKLF GYQSLSPEIT
310 320 330 340 350
PGNQSDGGGT LTSSVEGSAP GSVEDLLSQD ENTLMDHQHS NSMDNLDSEC
360 370 380 390 400
SEVYQPLTSS DDALDAPSSS ESEGVPSIER SRKGSSGNAS EVSVACLTER
410 420 430 440 450
IHQMEENQHS TSEELQATLQ ELADLQQITQ ELNSENERLG EEKVILMESL
460 470 480 490 500
CQQSDKLEHF GRQIEYFRSL LDEHHISYVI DEDVKSGRYM ELEQRYMDLA
510 520 530 540 550
ENARFEREQL LGVQQHLSNT LKMAEQDNKE AQEMIGALKE RSHHMERIIE
560 570 580 590 600
SEQKGKAALA ATLEEYKATV ASDQIEMNRL KAQLENEKQK VAELYSIHNS
610 620 630 640 650
GDKSDIQDLL ESVRLDKEKA ETLASSLQED LAHTRNDANR LQDTIAKVED
660 670 680 690 700
EYRAFQEEAK KQIEDLNMTL EKLRSELEEK DTERSDMKET IFELEDEVEQ
710 720 730 740 750
HRAVKLHDNL IISDLENTVK KLQDQKHDME REIKTLHRRL REESAEWRQF
760 770 780 790 800
QADLQTAVVI ANDIKSEAQE EIGDLKRRLH EAQEKNEKLT KELEEIKSRK
810 820 830 840 850
QEEERGRVYN YMNAVERDLA ALRQGMGLSR RSSTSSEPTP TVKTLIKSFD
860 870 880 890 900
SASQVPNAAA AAIPRTPLSP SPMKTPPAAA VSPMQRHSIS GPISTSKPLT
910 920 930 940 950
ALSDKRSNYG ELPVQEHLLR TSSTSRPASL PRVPAMESAK TISVSRRSSE
960 970 980 990 1000
EMKRDISASE GASPASLMAM GTTSPQLSLS SSPTASVTPS TRSRIREERK
1010 1020 1030 1040 1050
DPLSALAREY GGSKRNALLK WCQKKTEGYQ NIDITNFSSS WNDGLAFCAL
1060 1070 1080 1090 1100
LHTYLPAHIP YQELNSQDKK RNFTLAFQAA ESVGIKSTLD INEMARTERP
1110
DWQNVMLYVT AIYKYFET
Length:1,118
Mass (Da):124,488
Last modified:March 7, 2006 - v1
Checksum:i1670E69840146D8F
GO

Sequence cautioni

The sequence BAC41420 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY884297 mRNA. Translation: AAX84188.1.
AB093236 mRNA. Translation: BAC41420.1. Different initiation.
CCDSiCCDS48599.1.
RefSeqiNP_001139298.1. NM_001145826.1.
NP_700455.3. NM_153406.3.
XP_006514315.1. XM_006514252.2.
XP_011241891.1. XM_011243589.1.
XP_011241892.1. XM_011243590.1.
UniGeneiMm.27716.

Genome annotation databases

EnsembliENSMUST00000105421; ENSMUSP00000101061; ENSMUSG00000033444.
GeneIDi74392.
KEGGimmu:74392.
UCSCiuc007fqe.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY884297 mRNA. Translation: AAX84188.1.
AB093236 mRNA. Translation: BAC41420.1. Different initiation.
CCDSiCCDS48599.1.
RefSeqiNP_001139298.1. NM_001145826.1.
NP_700455.3. NM_153406.3.
XP_006514315.1. XM_006514252.2.
XP_011241891.1. XM_011243589.1.
XP_011241892.1. XM_011243590.1.
UniGeneiMm.27716.

3D structure databases

ProteinModelPortaliQ2KN98.
SMRiQ2KN98. Positions 1015-1114.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ2KN98. 1 interaction.
STRINGi10090.ENSMUSP00000045099.

PTM databases

iPTMnetiQ2KN98.
PhosphoSiteiQ2KN98.

Proteomic databases

MaxQBiQ2KN98.
PaxDbiQ2KN98.
PeptideAtlasiQ2KN98.
PRIDEiQ2KN98.

Protocols and materials databases

DNASUi74392.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000105421; ENSMUSP00000101061; ENSMUSG00000033444.
GeneIDi74392.
KEGGimmu:74392.
UCSCiuc007fqe.2. mouse.

Organism-specific databases

CTDi23384.
MGIiMGI:1921642. Specc1l.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG4678. Eukaryota.
COG5069. LUCA.
GeneTreeiENSGT00760000118856.
HOGENOMiHOG000015307.
HOVERGENiHBG056096.
InParanoidiQ2KN98.
PhylomeDBiQ2KN98.
TreeFamiTF316716.

Miscellaneous databases

PROiQ2KN98.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033444.
CleanExiMM_SPECC1L.
GenevisibleiQ2KN98. MM.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
InterProiIPR001715. CH-domain.
[Graphical view]
PfamiPF00307. CH. 1 hit.
[Graphical view]
SMARTiSM00033. CH. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiPS50021. CH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYTSA_MOUSE
AccessioniPrimary (citable) accession number: Q2KN98
Secondary accession number(s): Q8CHF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: March 7, 2006
Last modified: September 7, 2016
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.