Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytospin-A

Gene

Specc1l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration (By similarity).By similarity

GO - Biological processi

  • actin cytoskeleton organization Source: MGI
  • cell adhesion Source: MGI
  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • cell migration Source: MGI
  • face morphogenesis Source: MGI
  • negative regulation of actin filament depolymerization Source: MGI
  • negative regulation of microtubule depolymerization Source: MGI

Keywordsi

Biological processCell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Cytospin-A
Alternative name(s):
SPECC1-like protein
Sperm antigen with calponin homology and coiled-coil domains 1-like
Gene namesi
Name:Specc1l
Synonyms:Cytsa, Kiaa0376
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1921642 Specc1l

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Gap junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002310191 – 1118Cytospin-AAdd BLAST1118

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei385PhosphoserineCombined sources1
Modified residuei386PhosphoserineCombined sources1
Modified residuei390PhosphoserineCombined sources1
Modified residuei869PhosphoserineBy similarity1
Modified residuei882PhosphoserineBy similarity1
Modified residuei888PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ2KN98
PaxDbiQ2KN98
PeptideAtlasiQ2KN98
PRIDEiQ2KN98

PTM databases

iPTMnetiQ2KN98
PhosphoSitePlusiQ2KN98

Expressioni

Developmental stagei

At 9.5-10.5 dpc, expressed in the developing maxillary prominence and the lateral nasal process, as well as in the limbs and eye.1 Publication

Gene expression databases

BgeeiENSMUSG00000033444
CleanExiMM_SPECC1L
ExpressionAtlasiQ2KN98 baseline and differential
GenevisibleiQ2KN98 MM

Interactioni

Subunit structurei

May interact with both microtubules and actin cytoskeleton.

Protein-protein interaction databases

BioGridi216715, 2 interactors
IntActiQ2KN98, 3 interactors
STRINGi10090.ENSMUSP00000045099

Structurei

3D structure databases

ProteinModelPortaliQ2KN98
SMRiQ2KN98
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1012 – 1117Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST106

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili168 – 281Sequence analysisAdd BLAST114
Coiled coili395 – 450Sequence analysisAdd BLAST56
Coiled coili488 – 808Sequence analysisAdd BLAST321

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi45 – 48Poly-Ala4
Compositional biasi858 – 862Poly-Ala5

Sequence similaritiesi

Belongs to the cytospin-A family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4678 Eukaryota
COG5069 LUCA
GeneTreeiENSGT00760000118856
HOGENOMiHOG000015307
HOVERGENiHBG056096
InParanoidiQ2KN98
PhylomeDBiQ2KN98
TreeFamiTF316716

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR001715 CH-domain
IPR036872 CH_dom_sf
PfamiView protein in Pfam
PF00307 CH, 1 hit
SMARTiView protein in SMART
SM00033 CH, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit

Sequencei

Sequence statusi: Complete.

Q2KN98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKANRSAGS VPKVSGISKP QTVEKSKPEN SSSAPTGVKP VRPGAAAALS
60 70 80 90 100
KTKSNDDLLA GMAGGVNVTN GIKAKKSTCS SAAPSAPAPA MTISENKSKI
110 120 130 140 150
STGTSSSAKR STSAGNKESS STRERLRERT RLNQSKKLPS VSQGANDVAL
160 170 180 190 200
AKRSRSRTAA EGDIRMSKSK SDNQISDKAA LEAKVKDLLT LAKTKDVEIL
210 220 230 240 250
HLRNELRDMR AQLGISEDHC EGEDRSEVKE TIIAHQPTDV ESTLLQLQEQ
260 270 280 290 300
NTAIREELNQ LKNENRMLKD RLNALGFSLE QRLDNSEKLF GYQSLSPEIT
310 320 330 340 350
PGNQSDGGGT LTSSVEGSAP GSVEDLLSQD ENTLMDHQHS NSMDNLDSEC
360 370 380 390 400
SEVYQPLTSS DDALDAPSSS ESEGVPSIER SRKGSSGNAS EVSVACLTER
410 420 430 440 450
IHQMEENQHS TSEELQATLQ ELADLQQITQ ELNSENERLG EEKVILMESL
460 470 480 490 500
CQQSDKLEHF GRQIEYFRSL LDEHHISYVI DEDVKSGRYM ELEQRYMDLA
510 520 530 540 550
ENARFEREQL LGVQQHLSNT LKMAEQDNKE AQEMIGALKE RSHHMERIIE
560 570 580 590 600
SEQKGKAALA ATLEEYKATV ASDQIEMNRL KAQLENEKQK VAELYSIHNS
610 620 630 640 650
GDKSDIQDLL ESVRLDKEKA ETLASSLQED LAHTRNDANR LQDTIAKVED
660 670 680 690 700
EYRAFQEEAK KQIEDLNMTL EKLRSELEEK DTERSDMKET IFELEDEVEQ
710 720 730 740 750
HRAVKLHDNL IISDLENTVK KLQDQKHDME REIKTLHRRL REESAEWRQF
760 770 780 790 800
QADLQTAVVI ANDIKSEAQE EIGDLKRRLH EAQEKNEKLT KELEEIKSRK
810 820 830 840 850
QEEERGRVYN YMNAVERDLA ALRQGMGLSR RSSTSSEPTP TVKTLIKSFD
860 870 880 890 900
SASQVPNAAA AAIPRTPLSP SPMKTPPAAA VSPMQRHSIS GPISTSKPLT
910 920 930 940 950
ALSDKRSNYG ELPVQEHLLR TSSTSRPASL PRVPAMESAK TISVSRRSSE
960 970 980 990 1000
EMKRDISASE GASPASLMAM GTTSPQLSLS SSPTASVTPS TRSRIREERK
1010 1020 1030 1040 1050
DPLSALAREY GGSKRNALLK WCQKKTEGYQ NIDITNFSSS WNDGLAFCAL
1060 1070 1080 1090 1100
LHTYLPAHIP YQELNSQDKK RNFTLAFQAA ESVGIKSTLD INEMARTERP
1110
DWQNVMLYVT AIYKYFET
Length:1,118
Mass (Da):124,488
Last modified:March 7, 2006 - v1
Checksum:i1670E69840146D8F
GO

Sequence cautioni

The sequence BAC41420 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY884297 mRNA Translation: AAX84188.1
AB093236 mRNA Translation: BAC41420.1 Different initiation.
CCDSiCCDS48599.1
RefSeqiNP_001139298.1, NM_001145826.1
NP_700455.3, NM_153406.3
XP_006514315.1, XM_006514252.3
XP_011241891.1, XM_011243589.2
XP_017169616.1, XM_017314127.1
UniGeneiMm.27716

Genome annotation databases

EnsembliENSMUST00000218766; ENSMUSP00000151322; ENSMUSG00000033444
GeneIDi74392
KEGGimmu:74392
UCSCiuc007fqe.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCYTSA_MOUSE
AccessioniPrimary (citable) accession number: Q2KN98
Secondary accession number(s): Q8CHF9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: March 7, 2006
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health