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Protein

Cytospin-A

Gene

specc1l

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Cytospin-A
Alternative name(s):
SPECC1-like protein
Sperm antigen with calponin homology and coiled-coil domains 1-like
Gene namesi
Name:specc1l
Synonyms:cytsa
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-5937736. specc1l.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Gap junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002310261 – 1101Cytospin-AAdd BLAST1101

Proteomic databases

PaxDbiQ2KN96.

Interactioni

Subunit structurei

May interact with both microtubules and actin cytoskeleton.By similarity

Protein-protein interaction databases

STRINGi8364.ENSXETP00000009170.

Structurei

3D structure databases

ProteinModelPortaliQ2KN96.
SMRiQ2KN96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini995 – 1100Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST106

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili162 – 254Sequence analysisAdd BLAST93
Coiled coili373 – 427Sequence analysisAdd BLAST55
Coiled coili492 – 785Sequence analysisAdd BLAST294

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi344 – 349Poly-Ser6
Compositional biasi833 – 841Poly-Ala9
Compositional biasi902 – 969Ser-richAdd BLAST68

Sequence similaritiesi

Belongs to the cytospin-A family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4678. Eukaryota.
COG5069. LUCA.
HOVERGENiHBG056096.
InParanoidiQ2KN96.
OrthoDBiEOG091G01BX.

Family and domain databases

CDDicd00014. CH. 1 hit.
Gene3Di1.10.418.10. 1 hit.
InterProiView protein in InterPro
IPR001715. CH-domain.
IPR036872. CH_dom_sf.
PfamiView protein in Pfam
PF00307. CH. 1 hit.
SMARTiView protein in SMART
SM00033. CH. 1 hit.
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiView protein in PROSITE
PS50021. CH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q2KN96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKASRSVGA APKVPANNKS QATERSKSES SAPTASKVSR PGSSLSKAKS
60 70 80 90 100
NDDLLAGMAG GLPASNSVKV KKNSTTSYPN SGTAMSGQEG RTRSSAGSSS
110 120 130 140 150
NTKRSGSSGA KEVGSSRERL RERSRLTANK KPQGLGVGTG EVSAPSKRSR
160 170 180 190 200
GRTDSDMIRM SKSKSDNQIS DRAALEAKVK ELMNLAKNKD AEILLLRTEL
210 220 230 240 250
RDTRSQLGQD VSDKSPDDLP LIHLQEQNTT VCEELQQLKS ENRMLKDRLN
260 270 280 290 300
ALGFSLGQQP DDPDKLYGFQ SLGINPGSHS DCGGGTLTSS VEGSAPGSME
310 320 330 340 350
DLLSQDESTL TGERRSSSMD NLDSECSEVY QPLTSSDDAL DAPSSSSESE
360 370 380 390 400
GLPSTERSRK GSSGNASEVS VACLTERIHQ MEENQHSTAE ELQATLQELA
410 420 430 440 450
DLQQITQELN SENERLGEEK VILMDSLCQQ SDKLELFSRQ LEYAQALLDE
460 470 480 490 500
HHIAYSLDED LKSSRYLDLE QRYMDLAENG RFEREQLLGV QQHLSNSLKM
510 520 530 540 550
AEQDNKDAQD VIRALKERNH HMERIAEAEQ LSKQALAATL EEYKATLNSE
560 570 580 590 600
QGECARLKAL LEQEKQRVAE LYSIHSSGDA SHIQNLLESV RSDKEKAESL
610 620 630 640 650
ASSLQEELLH ARTDVNRMQD AFGKLEDEYR AFREEAQKQV SELTLALEKV
660 670 680 690 700
RHELEEKETE LSDMKETIFE LEDEVEQHRA VKLHDNLIIS DVENAVKKLQ
710 720 730 740 750
DQKHDMEREI KILNRKLREE SAEWRQFQAD LQTAVVIAND IKSEAQEEIG
760 770 780 790 800
ELKRQLQEAL EKNEKLAKEM ENATSRKQEE ERGRVYNYMN AVERDLAALR
810 820 830 840 850
QGMGLNRRSS TSSDPAPTVK TLIKSFDNAS SQAAAVAAAA ATPISRTPLS
860 870 880 890 900
PSPMKTPPAA AVSPMQRHSI SGPISVAKSL PGLSEKRPSY AEIPVQEHML
910 920 930 940 950
RSSSSSRSAA SLPRVPAIDN AKSISVSRRS SEELKRDISV PDGSSAPSLM
960 970 980 990 1000
VMTSPSPQLS LSSSSPTASV TPTARSRIRE ERKDPLAALA REYGGSKRNA
1010 1020 1030 1040 1050
LLKWCQKKTE GYPNIDITNF SSSWNDGLAF CALLHTYLPA HIPYQELTNQ
1060 1070 1080 1090 1100
DKRRNFTLAF QAAESVGIKS TLDINEMVRT ERPDWQCLMT YVTSIYKYFE

T
Length:1,101
Mass (Da):121,701
Last modified:March 7, 2006 - v1
Checksum:iF290C2ADE48B5272
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY884299 mRNA. Translation: AAX84190.1.
RefSeqiNP_001037875.1. NM_001044410.1.
UniGeneiStr.38067.

Genome annotation databases

GeneIDi733457.
KEGGixtr:733457.

Similar proteinsi

Entry informationi

Entry nameiCYTSA_XENTR
AccessioniPrimary (citable) accession number: Q2KN96
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: March 7, 2006
Last modified: February 28, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome