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Protein

Kinesin-like protein KIF26B

Gene

KIF26B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi546 – 553ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-HSA-983189. Kinesins.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF26B
Gene namesi
Name:KIF26B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:25484. KIF26B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi55083.
OpenTargetsiENSG00000162849.
PharmGKBiPA145148575.

Polymorphism and mutation databases

BioMutaiKIF26B.
DMDMi121948325.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003073011 – 2108Kinesin-like protein KIF26BAdd BLAST2108

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1855PhosphothreonineBy similarity1
Modified residuei1958PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation at Thr-1855 and Ser-1958 by CDKs, mainly CDK2 and CDK5, enhances the interaction with NEDD4, polyubiquitination, and subsequent proteasomal degradation. Phosphorylation occurs upon loss of interaction with microtubules (By similarity).By similarity
Polyubiquitinated by NEDD4, resulting in proteasomal degradation.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ2KJY2.
PaxDbiQ2KJY2.
PeptideAtlasiQ2KJY2.
PRIDEiQ2KJY2.

PTM databases

iPTMnetiQ2KJY2.
PhosphoSitePlusiQ2KJY2.

Expressioni

Gene expression databases

BgeeiENSG00000162849.
CleanExiHS_KIF26B.
ExpressionAtlasiQ2KJY2. baseline and differential.
GenevisibleiQ2KJY2. HS.

Organism-specific databases

HPAiHPA027709.
HPA028478.
HPA028561.
HPA028562.

Interactioni

Subunit structurei

Interacts with MYH10.By similarity

Protein-protein interaction databases

BioGridi120398. 24 interactors.
IntActiQ2KJY2. 14 interactors.
STRINGi9606.ENSP00000385545.

Structurei

3D structure databases

ProteinModelPortaliQ2KJY2.
SMRiQ2KJY2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini450 – 801Kinesin motorPROSITE-ProRule annotationAdd BLAST352

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi58 – 126Gly-richAdd BLAST69
Compositional biasi1649 – 1797Ser-richAdd BLAST149

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIF26 subfamily.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4280. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00650000093360.
HOGENOMiHOG000081802.
HOVERGENiHBG108063.
InParanoidiQ2KJY2.
KOiK10404.
OMAiDHRNSHM.
OrthoDBiEOG091G0097.
PhylomeDBiQ2KJY2.
TreeFamiTF105235.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 2 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q2KJY2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNSVAGNKER LAVSTRGKKY GVNEVCSPTK PAAPFSPESW YRKAYEESRA
60 70 80 90 100
GSRPTPEGAG SALGSSGTPS PGSGTSSPSS FTGSPGPASP GIGTSSPGSL
110 120 130 140 150
GGSPGFGTGS PGSGSGGGSS PGSDRGVWCE NCNARLVELK RQALRLLLPG
160 170 180 190 200
PFPGKDPAFS AVIHDKLQVP NTIRKAWNDR DNRCDICATH LNQLKQEAIQ
210 220 230 240 250
MVLTLEQAAG SEHYDASPCS PPPLSNIPTL VGSRHVGGLQ QPRDWAFVPA
260 270 280 290 300
PCATSNYTGF ANKHGSKPSS LGVSNGAEKK SGSPTHQAKV SLQMATSPSN
310 320 330 340 350
GNILNSVAIQ AHQYLDGTWS LSRTNGVTLY PYQISQLMTE SSREGLTEAV
360 370 380 390 400
LNRYNADKPS ACSVPASQGS CVASETSTGT SVAASFFARA AQKLNLSSKK
410 420 430 440 450
KKHRPSTSSA AEPPLFATSF SGILQTSPPP APPCLLRAVN KVKDTPGLGK
460 470 480 490 500
VKVMLRICST LARDTSESSS FLKVDPRKKQ ITLYDPLTCG GQNAFQKRGN
510 520 530 540 550
QVPPKMFAFD AVFPQDASQA EVCAGTVAEV IQSVVNGADG CVFCFGHAKL
560 570 580 590 600
GKSYTMIGKD DSMQNLGIIP CAISWLFKLI NERKEKTGAR FSVRVSAVEV
610 620 630 640 650
WGKEENLRDL LSEVATGSLQ DGQSPGVYLC EDPICGTQLQ NQSELRAPTA
660 670 680 690 700
EKAAFFLDAA IASRRSHQQD CDEDDHRNSH VFFTLHIYQY RMEKSGKGGM
710 720 730 740 750
SGGRSRLHLI DLGSCVKALS KNREGGSGLC LSLSALGNVI LALVNGSKHI
760 770 780 790 800
PYKESKLAML LRESLGNMNC RTTMIAHISA AVGSYAETLS TIQIASRVLR
810 820 830 840 850
MKKKKTKYTS SSSGGESSCE EGRMRRPTQL RPFHTRATVD PDFPIAHLSS
860 870 880 890 900
DPDYSSSSEQ SCDTVIYIGP NGTALSDKEL TDNEGPPDFV PIVPALQKTR
910 920 930 940 950
GDSRPAEAGE AAAGKSERDC LKCNTFAELQ ERLDCIDGSE EPSSFPFEEL
960 970 980 990 1000
PAQFGPEQAS RGPRLSQAAG ASPLSESDKE DNGSEGQLTN REGPELPASK
1010 1020 1030 1040 1050
MQRSHSPVPA AAPAHSPSPA SPRSVPGSSS QHSASPLVQS PSLQSSRESL
1060 1070 1080 1090 1100
NSCGFVEGKP RPMGSPRLGI ASLSKTSEYK PPSSPSQRCK VYTQKGVLPS
1110 1120 1130 1140 1150
PAPLPPSSKD SGVASRESLL QPEVRTPPVG MSPQVLKKSM SAGSEGFPET
1160 1170 1180 1190 1200
PVDDEQQAAT PSESKKEILS TTMVTVQQPL ELNGEDELVF TLVEELTISG
1210 1220 1230 1240 1250
VLDSGRPTSI ISFNSDCSAR ALASGSRPVS IISSISEDLE CYSSTAPVSE
1260 1270 1280 1290 1300
VSITQFLPLP KMSLDEKAQD AGSRRSSISS WLSEMSAGSE GEQSCHSFIA
1310 1320 1330 1340 1350
QTCFGHGEAM AEPVASEFVS SLQNTAVVCR EKPKASPDNL LILSEMGDDS
1360 1370 1380 1390 1400
FNKAAPIKGC KISTVSKAMV TISNTANLSS CEGYIPMKTN ITVYPCIAMS
1410 1420 1430 1440 1450
PRNIQEPEAP TATPKAGPTL AQSRESKENS AKKEMKFEDP WLKREEEVKK
1460 1470 1480 1490 1500
ETAHPNEEGM MRCETATGPS NAETRAEQEQ DGKPSPGDRL SSSSGEVSAS
1510 1520 1530 1540 1550
PVTDNFRRVV DGCEMALPGL ATQSPVHPNK SVKSSSLPRA FQKASRQEEP
1560 1570 1580 1590 1600
DSLSYYCAAE TNGVGAASGT PPSKATLEGK VASPKHCVLA RPKGTPPLPP
1610 1620 1630 1640 1650
VRKSSLDQKN RASPQHSASG SGTSSPLNQP AAFPAGLPDE PSGKTKDASS
1660 1670 1680 1690 1700
SSKLFSAKLE QLASRSNSLG RATVSHYECL SLERAESLSS VSSRLHAGKD
1710 1720 1730 1740 1750
GTMPRAGRSL GRSAGTSPPS SGASPKAGQS KISAVSRLLL ASPRARGPSA
1760 1770 1780 1790 1800
STTKTLSFST KSLPQAVGQG SSSPPGGKHT PWSTQSLSRN RSSGLASKLP
1810 1820 1830 1840 1850
LRAVSGRISE LLQGGAGARG LQLRAGPEAE ARGGALAEDE PAAAHLLPSP
1860 1870 1880 1890 1900
YSKITPPRRP HRCSSGHGSD NSSVLSGELP PAMGKTALFY HSGGSSGYES
1910 1920 1930 1940 1950
VMRDSEATGS ASSAQDSTSE NSSSVGGRCR SLKTPKKRSN PGSQRRRLIP
1960 1970 1980 1990 2000
ALSLDTSSPV RKPPNSTGVR WVDGPLRSSP RGLGEPFEIK VYEIDDVERL
2010 2020 2030 2040 2050
QRRRGGASKE AMCFNAKLKI LEHRQQRIAE VRAKYEWLMK ELEATKQYLM
2060 2070 2080 2090 2100
LDPNKWLSEF DLEQVWELDS LEYLEALECV TERLESRVNF CKAHLMMITC

FDITSRRR
Length:2,108
Mass (Da):223,883
Last modified:March 7, 2006 - v1
Checksum:i18F9ED20A1E119E2
GO
Isoform 2 (identifier: Q2KJY2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-383: Missing.
     384-389: ASFFAR → MDWKAV

Note: No experimental confirmation available.
Show »
Length:1,725
Mass (Da):184,420
Checksum:iD33C1D29A934382E
GO

Sequence cautioni

The sequence AAH42481 differs from that shown. Probable cloning artifact.Curated
The sequence BAA91469 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC86076 differs from that shown. Aberrant splicing.Curated
The sequence BAC87614 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti83G → S in BAC86076 (PubMed:14702039).Curated1
Sequence conflicti108T → A in BAC86076 (PubMed:14702039).Curated1
Sequence conflicti243R → M in AAH35896 (PubMed:15489334).Curated1
Sequence conflicti1682L → P in BAA91469 (PubMed:14702039).Curated1
Sequence conflicti1746R → H in BAA91469 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0286871 – 383Missing in isoform 2. 1 PublicationAdd BLAST383
Alternative sequenceiVSP_028693384 – 389ASFFAR → MDWKAV in isoform 2. 1 Publication6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY923834 mRNA. Translation: AAY17361.1.
AK001019 mRNA. Translation: BAA91469.1. Different initiation.
AK125187 mRNA. Translation: BAC86076.1. Sequence problems.
AK128806 mRNA. Translation: BAC87614.1. Sequence problems.
BC035896 mRNA. Translation: AAH35896.1.
BC042481 mRNA. Translation: AAH42481.1. Sequence problems.
CCDSiCCDS44342.1. [Q2KJY2-1]
RefSeqiNP_060482.2. NM_018012.3. [Q2KJY2-1]
UniGeneiHs.143134.
Hs.368096.

Genome annotation databases

EnsembliENST00000407071; ENSP00000385545; ENSG00000162849. [Q2KJY2-1]
GeneIDi55083.
KEGGihsa:55083.
UCSCiuc001ibf.1. human. [Q2KJY2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY923834 mRNA. Translation: AAY17361.1.
AK001019 mRNA. Translation: BAA91469.1. Different initiation.
AK125187 mRNA. Translation: BAC86076.1. Sequence problems.
AK128806 mRNA. Translation: BAC87614.1. Sequence problems.
BC035896 mRNA. Translation: AAH35896.1.
BC042481 mRNA. Translation: AAH42481.1. Sequence problems.
CCDSiCCDS44342.1. [Q2KJY2-1]
RefSeqiNP_060482.2. NM_018012.3. [Q2KJY2-1]
UniGeneiHs.143134.
Hs.368096.

3D structure databases

ProteinModelPortaliQ2KJY2.
SMRiQ2KJY2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120398. 24 interactors.
IntActiQ2KJY2. 14 interactors.
STRINGi9606.ENSP00000385545.

PTM databases

iPTMnetiQ2KJY2.
PhosphoSitePlusiQ2KJY2.

Polymorphism and mutation databases

BioMutaiKIF26B.
DMDMi121948325.

Proteomic databases

MaxQBiQ2KJY2.
PaxDbiQ2KJY2.
PeptideAtlasiQ2KJY2.
PRIDEiQ2KJY2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000407071; ENSP00000385545; ENSG00000162849. [Q2KJY2-1]
GeneIDi55083.
KEGGihsa:55083.
UCSCiuc001ibf.1. human. [Q2KJY2-1]

Organism-specific databases

CTDi55083.
DisGeNETi55083.
GeneCardsiKIF26B.
HGNCiHGNC:25484. KIF26B.
HPAiHPA027709.
HPA028478.
HPA028561.
HPA028562.
MIMi614026. gene.
neXtProtiNX_Q2KJY2.
OpenTargetsiENSG00000162849.
PharmGKBiPA145148575.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4280. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00650000093360.
HOGENOMiHOG000081802.
HOVERGENiHBG108063.
InParanoidiQ2KJY2.
KOiK10404.
OMAiDHRNSHM.
OrthoDBiEOG091G0097.
PhylomeDBiQ2KJY2.
TreeFamiTF105235.

Enzyme and pathway databases

ReactomeiR-HSA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-HSA-983189. Kinesins.

Miscellaneous databases

ChiTaRSiKIF26B. human.
GenomeRNAii55083.
PROiQ2KJY2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162849.
CleanExiHS_KIF26B.
ExpressionAtlasiQ2KJY2. baseline and differential.
GenevisibleiQ2KJY2. HS.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 2 hits.
PfamiPF00225. Kinesin. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKI26B_HUMAN
AccessioniPrimary (citable) accession number: Q2KJY2
Secondary accession number(s): Q6ZQR9
, Q6ZUZ0, Q8IUN3, Q8IVR1, Q9NWB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 7, 2006
Last modified: November 2, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.