ID   PLD3_BOVIN              Reviewed;         490 AA.
AC   Q2KJJ8;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   24-MAR-2009, entry version 27.
DE   RecName: Full=Phospholipase D3;
DE            Short=PLD 3;
DE            EC=3.1.4.4;
DE   AltName: Full=Choline phosphatase 3;
DE   AltName: Full=Phosphatidylcholine-hydrolyzing phospholipase D3;
GN   Name=PLD3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: A phosphatidylcholine + H(2)O = choline + a
CC       phosphatidate.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass
CC       type II membrane protein (By similarity).
CC   -!- PTM: Glycosylated (By similarity).
CC   -!- SIMILARITY: Belongs to the phospholipase D family.
CC   -!- SIMILARITY: Contains 2 PLD phosphodiesterase domains.
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DR   EMBL; BC105309; AAI05310.1; -; mRNA.
DR   IPI; IPI00711106; -.
DR   RefSeq; NP_001071509.1; -.
DR   UniGene; Bt.16204; -.
DR   Ensembl; ENSBTAG00000019150; Bos taurus.
DR   GeneID; 613932; -.
DR   KEGG; bta:613932; -.
DR   HOVERGEN; Q2KJJ8; -.
DR   BRENDA; 3.1.4.4; 251.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070290; F:NAPE-specific phospholipase D activity; IEA:EC.
DR   GO; GO:0004630; F:phospholipase D activity; IEA:EC.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR013582; PLD_envelope.
DR   InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR   Pfam; PF08371; PLD_envelope; 1.
DR   Pfam; PF00614; PLDc; 2.
DR   SMART; SM00155; PLDc; 2.
DR   PROSITE; PS50035; PLD; 2.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Glycoprotein; Hydrolase; Lipid degradation;
KW   Membrane; Repeat; Signal-anchor; Transmembrane.
FT   CHAIN         1    490       Phospholipase D3.
FT                                /FTId=PRO_0000280325.
FT   TOPO_DOM      1     38       Cytoplasmic (Potential).
FT   TRANSMEM     39     59       Signal-anchor for type II membrane
FT                                protein (Potential).
FT   TOPO_DOM     60    490       Lumenal (Potential).
FT   DOMAIN      196    223       PLD phosphodiesterase 1.
FT   DOMAIN      411    437       PLD phosphodiesterase 2.
FT   ACT_SITE    201    201       Potential.
FT   ACT_SITE    203    203       Potential.
FT   ACT_SITE    208    208       Potential.
FT   CARBOHYD    132    132       N-linked (GlcNAc...) (Potential).
SQ   SEQUENCE   490 AA;  54619 MW;  8D5F78A548AD3BE8 CRC64;
     MKPKLMYQEL KVPAEEPASE LPMNEIEAWK AAEKKARWVL LVLILAVVGF GALMTQLFLW
     EYGDLHLFGP NQRPAPCYDP CEAVLVESIP EGLDFPNAST SNPSTSQAWL GLLAGAHSSL
     DIASFYWTLT NNDTHTQEAS AQQGEEVLRQ LQTLAPRGVK VRIAVSKPNG PQPQADLQAL
     LQSGAQVRMV DMQKLTHGVL HTKFWVVDQT HFYLGSANMD WRSLTQVKEL GVVMYNCSCL
     ARDLTKIFEA YWFLGQAGSS IPSTWPRPYD TRYNQETPME ICLNGTPALA YLASAPPPLC
     PSGRTPDLKA LLNVVDNARS FIYIAVMNYL PIMEFSHPRR FWPAIDDGLR RAAYERGVKV
     RLLISCWGHS DPSMRAFLLS LAALRDNHTH SDIQVKLFVV PADDAQARIP YARVNHNKYM
     VTERATYIGT SNWSGSYFTE TAGTSLLVTQ NGRGGLRSQL EAVFLRDWDS PYSHDLDAAA
     DSVGNACRLL
//