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Protein

Phospholipase D3

Gene

PLD3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Probably involved in APP processing.By similarity

Catalytic activityi

A phosphatidylcholine + H2O = choline + a phosphatidate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei201 – 2011PROSITE-ProRule annotation
Active sitei203 – 2031PROSITE-ProRule annotation
Active sitei208 – 2081PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipase D3 (EC:3.1.4.4)
Short name:
PLD 3
Alternative name(s):
Choline phosphatase 3
Phosphatidylcholine-hydrolyzing phospholipase D3
Gene namesi
Name:PLD3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3838CytoplasmicSequence analysisAdd
BLAST
Transmembranei39 – 5921Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini60 – 490431LumenalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490Phospholipase D3PRO_0000280325Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi132 – 1321N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ2KJJ8.
PRIDEiQ2KJJ8.

Interactioni

Subunit structurei

Interacts with APP.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000041666.

Structurei

3D structure databases

ProteinModelPortaliQ2KJJ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini196 – 22328PLD phosphodiesterase 1PROSITE-ProRule annotationAdd
BLAST
Domaini411 – 43727PLD phosphodiesterase 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the phospholipase D family.Curated
Contains 2 PLD phosphodiesterase domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3603. Eukaryota.
ENOG410XQZ4. LUCA.
GeneTreeiENSGT00390000009798.
HOGENOMiHOG000293407.
HOVERGENiHBG052880.
InParanoidiQ2KJJ8.
KOiK16860.
OMAiPRFLSTY.
OrthoDBiEOG70KGP9.
TreeFamiTF313378.

Family and domain databases

InterProiIPR032803. PLDc_3.
IPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
PfamiPF00614. PLDc. 1 hit.
PF13918. PLDc_3. 1 hit.
[Graphical view]
SMARTiSM00155. PLDc. 2 hits.
[Graphical view]
PROSITEiPS50035. PLD. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2KJJ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPKLMYQEL KVPAEEPASE LPMNEIEAWK AAEKKARWVL LVLILAVVGF
60 70 80 90 100
GALMTQLFLW EYGDLHLFGP NQRPAPCYDP CEAVLVESIP EGLDFPNAST
110 120 130 140 150
SNPSTSQAWL GLLAGAHSSL DIASFYWTLT NNDTHTQEAS AQQGEEVLRQ
160 170 180 190 200
LQTLAPRGVK VRIAVSKPNG PQPQADLQAL LQSGAQVRMV DMQKLTHGVL
210 220 230 240 250
HTKFWVVDQT HFYLGSANMD WRSLTQVKEL GVVMYNCSCL ARDLTKIFEA
260 270 280 290 300
YWFLGQAGSS IPSTWPRPYD TRYNQETPME ICLNGTPALA YLASAPPPLC
310 320 330 340 350
PSGRTPDLKA LLNVVDNARS FIYIAVMNYL PIMEFSHPRR FWPAIDDGLR
360 370 380 390 400
RAAYERGVKV RLLISCWGHS DPSMRAFLLS LAALRDNHTH SDIQVKLFVV
410 420 430 440 450
PADDAQARIP YARVNHNKYM VTERATYIGT SNWSGSYFTE TAGTSLLVTQ
460 470 480 490
NGRGGLRSQL EAVFLRDWDS PYSHDLDAAA DSVGNACRLL
Length:490
Mass (Da):54,619
Last modified:March 7, 2006 - v1
Checksum:i8D5F78A548AD3BE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105309 mRNA. Translation: AAI05310.1.
RefSeqiNP_001071509.1. NM_001078041.2.
XP_005219060.1. XM_005219003.3.
XP_005219061.1. XM_005219004.3.
XP_005219062.1. XM_005219005.2.
UniGeneiBt.16204.

Genome annotation databases

EnsembliENSBTAT00000044153; ENSBTAP00000041666; ENSBTAG00000019150.
GeneIDi613932.
KEGGibta:613932.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105309 mRNA. Translation: AAI05310.1.
RefSeqiNP_001071509.1. NM_001078041.2.
XP_005219060.1. XM_005219003.3.
XP_005219061.1. XM_005219004.3.
XP_005219062.1. XM_005219005.2.
UniGeneiBt.16204.

3D structure databases

ProteinModelPortaliQ2KJJ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000041666.

Proteomic databases

PaxDbiQ2KJJ8.
PRIDEiQ2KJJ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000044153; ENSBTAP00000041666; ENSBTAG00000019150.
GeneIDi613932.
KEGGibta:613932.

Organism-specific databases

CTDi23646.

Phylogenomic databases

eggNOGiKOG3603. Eukaryota.
ENOG410XQZ4. LUCA.
GeneTreeiENSGT00390000009798.
HOGENOMiHOG000293407.
HOVERGENiHBG052880.
InParanoidiQ2KJJ8.
KOiK16860.
OMAiPRFLSTY.
OrthoDBiEOG70KGP9.
TreeFamiTF313378.

Miscellaneous databases

NextBioi20898846.

Family and domain databases

InterProiIPR032803. PLDc_3.
IPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
PfamiPF00614. PLDc. 1 hit.
PF13918. PLDc_3. 1 hit.
[Graphical view]
SMARTiSM00155. PLDc. 2 hits.
[Graphical view]
PROSITEiPS50035. PLD. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiPLD3_BOVIN
AccessioniPrimary (citable) accession number: Q2KJJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 7, 2006
Last modified: April 13, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.