Q2KJJ8 (PLD3_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phospholipase D3
Short name=PLD 3
EC=3.1.4.4

Alternative name(s):
Choline phosphatase 3
Phosphatidylcholine-hydrolyzing phospholipase D3

Gene names

Name:

PLD3

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	490 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	A phosphatidylcholine + H2O = choline + a phosphatidate.
Subcellular location	Endoplasmic reticulum membrane; Single-pass type II membrane protein By similarity.
Post-translational modification	Glycosylated By similarity.
Sequence similarities	Belongs to the phospholipase D family. Contains 2 PLD phosphodiesterase domains.

Ontologies

Keywords
Biological process	Lipid degradation
Cellular component	Endoplasmic reticulum Membrane
Domain	Repeat Signal-anchor Transmembrane Transmembrane helix
Molecular function	Hydrolase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NAPE-specific phospholipase D activity Inferred from electronic annotation. Source: EC phospholipase D activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 490	490	Phospholipase D3		PRO_0000280325
Regions
	Topological domain	1 – 38	38	Cytoplasmic Potential
	Transmembrane	39 – 59	21	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	60 – 490	431	Lumenal Potential
	Domain	196 – 223	28	PLD phosphodiesterase 1
	Domain	411 – 437	27	PLD phosphodiesterase 2
Sites
	Active site	201	1	Potential
	Active site	203	1	Potential
	Active site	208	1	Potential
Amino acid modifications
	Glycosylation	132	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q2KJJ8 [UniParc]. Last modified March 7, 2006. Version 1. Checksum: 8D5F78A548AD3BE8	FASTA	490	54,619
	10 20 30 40 50 60 MKPKLMYQEL KVPAEEPASE LPMNEIEAWK AAEKKARWVL LVLILAVVGF GALMTQLFLW 70 80 90 100 110 120 EYGDLHLFGP NQRPAPCYDP CEAVLVESIP EGLDFPNAST SNPSTSQAWL GLLAGAHSSL 130 140 150 160 170 180 DIASFYWTLT NNDTHTQEAS AQQGEEVLRQ LQTLAPRGVK VRIAVSKPNG PQPQADLQAL 190 200 210 220 230 240 LQSGAQVRMV DMQKLTHGVL HTKFWVVDQT HFYLGSANMD WRSLTQVKEL GVVMYNCSCL 250 260 270 280 290 300 ARDLTKIFEA YWFLGQAGSS IPSTWPRPYD TRYNQETPME ICLNGTPALA YLASAPPPLC 310 320 330 340 350 360 PSGRTPDLKA LLNVVDNARS FIYIAVMNYL PIMEFSHPRR FWPAIDDGLR RAAYERGVKV 370 380 390 400 410 420 RLLISCWGHS DPSMRAFLLS LAALRDNHTH SDIQVKLFVV PADDAQARIP YARVNHNKYM 430 440 450 460 470 480 VTERATYIGT SNWSGSYFTE TAGTSLLVTQ NGRGGLRSQL EAVFLRDWDS PYSHDLDAAA 490 DSVGNACRLL

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Ileum.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC105309 mRNA. Translation: AAI05310.1.
IPI	IPI00711106.
RefSeq	NP_001071509.1. NM_001078041.1.
UniGene	Bt.16204.
3D structure databases
ProteinModelPortal	Q2KJJ8.
ModBase	Search...
Proteomic databases
PRIDE	Q2KJJ8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000044153; ENSBTAP00000041666; ENSBTAG00000019150.
GeneID	613932.
KEGG	bta:613932.
Organism-specific databases
CTD	23646.
Phylogenomic databases
eggNOG	maNOG12623.
GeneTree	ENSGT00390000009798.
HOVERGEN	HBG052880.
InParanoid	Q2KJJ8.
OrthoDB	EOG4M65HG.
Family and domain databases
InterPro	IPR001736. PLipase_D/transphosphatidylase. IPR013582. PLipase_D_envelope. [Graphical view]
Pfam	PF08371. PLD_envelope. 1 hit. PF00614. PLDc. 1 hit. [Graphical view]
SMART	SM00155. PLDc. 2 hits. [Graphical view]
PROSITE	PS50035. PLD. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PLD3_BOVIN

Accession

Primary (citable) accession number: Q2KJJ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	March 7, 2006
Last modified:	November 16, 2011
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program