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Protein

AFG3-like protein 2

Gene

AFG3L2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Putative ATP-dependent protease.By similarity

Cofactori

Zn2+CuratedNote: Binds 1 zinc ion per subunit.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi575 – 5751Zinc; catalyticBy similarity
Active sitei576 – 5761By similarity
Metal bindingi579 – 5791Zinc; catalyticBy similarity
Metal bindingi650 – 6501Zinc; catalyticBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi349 – 3568ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Protein family/group databases

MEROPSiM41.016.

Names & Taxonomyi

Protein namesi
Recommended name:
AFG3-like protein 2 (EC:3.4.24.-)
Gene namesi
Name:AFG3L2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 24

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei144 – 16421HelicalSequence analysisAdd
BLAST
Transmembranei252 – 27221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 805805AFG3-like protein 2PRO_0000260448Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei118 – 1181N6-succinyllysineBy similarity

Proteomic databases

PaxDbiQ2KJI7.
PRIDEiQ2KJI7.

Interactioni

Subunit structurei

Homooligomer. Interacts with SPG7; the interaction is required for the efficient assembly of mitochondrial complex I.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000030993.

Structurei

3D structure databases

ProteinModelPortaliQ2KJI7.
SMRiQ2KJI7. Positions 306-549.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

In the N-terminal section; belongs to the AAA ATPase family.Curated
In the C-terminal section; belongs to the peptidase M41 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0731. Eukaryota.
COG0465. LUCA.
GeneTreeiENSGT00840000129814.
HOGENOMiHOG000217277.
HOVERGENiHBG050184.
InParanoidiQ2KJI7.
KOiK08956.
OMAiFPTENTD.
OrthoDBiEOG7NW68F.
TreeFamiTF105004.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_01458. FtsH.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR005936. FtsH.
IPR027417. P-loop_NTPase.
IPR011546. Pept_M41_FtsH_extracell.
IPR000642. Peptidase_M41.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF06480. FtsH_ext. 1 hit.
PF01434. Peptidase_M41. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01241. FtsH_fam. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q2KJI7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHRCLLLWG RGACRPRGMP PMLLPGGRTG STERLYLRML YRYATTQAKT
60 70 80 90 100
SRNSLLTDVI AAYQRLCSRP PKGFEKYFPN GKNGKKTSEP KEVMGEKKEP
110 120 130 140 150
KPAAAPRPSG GGVGGGGKRG GKKDDSHWWS RFQKGDIPWD DKEFKMYFLW
160 170 180 190 200
TALFWGGFLF YFLFKSSGRE ITWKDFANNY LSKGVVDRLE VVNKRFVRVT
210 220 230 240 250
FTPGKTPVDG QYVWFNIGSV DTFERNLETL QQELGIEGEN RVPVVYIAES
260 270 280 290 300
DGSFLLSMLP TVLIIAFLLY TIRRGPAGIG RTGRGMGGLF SVGETTAKVL
310 320 330 340 350
KDEIDVKFKD VAGCEEAKLE IMEFVNFLKN PKQYQDLGAK IPKGAILTGP
360 370 380 390 400
PGTGKTLLAK ATAGEANVPF ITVSGSEFLE MFVGVGPARV RDLFALARKN
410 420 430 440 450
APCILFIDEI DAVGRKRGRG NFGGQSEQEN TLNQLLVEMD GFNTTTNVVI
460 470 480 490 500
LAGTNRPDIL DPALMRPGRF DRQIFIGPPD IKGRASIFKV HLRPLKLDST
510 520 530 540 550
LEKEKLARKL ASLTPGFSGA DVANVCNEAA LIAARHLSDS INQKHFEQAI
560 570 580 590 600
ERVIGGLEKK TQVLQPEEKK TVAYHEAGHA VAGWYLEHAD PLLKVSIIPR
610 620 630 640 650
GKGLGYAQYL PREQYLYTRE QLLDRMCMTL GGRVSEEIFF GRITTGAQDD
660 670 680 690 700
LRKVTQSAYA QIVQFGMNEK VGQISFDLPR QGDMVLEKPY SEATARLIDD
710 720 730 740 750
EVRILINDAY KRTVALLTEK KADVEKVALL LLEKEVLDKN DMVELLGPRP
760 770 780 790 800
FAEKSTYEEF VEGTGSLDED TSLPEGLKDW NREREGSEEP SGEKVTSPVQ

GAGPA
Length:805
Mass (Da):89,388
Last modified:March 7, 2006 - v1
Checksum:i850FF0D0D111F1BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105322 mRNA. Translation: AAI05323.1.
RefSeqiNP_001039676.1. NM_001046211.1.
UniGeneiBt.1657.

Genome annotation databases

EnsembliENSBTAT00000031029; ENSBTAP00000030993; ENSBTAG00000011250.
GeneIDi515757.
KEGGibta:515757.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105322 mRNA. Translation: AAI05323.1.
RefSeqiNP_001039676.1. NM_001046211.1.
UniGeneiBt.1657.

3D structure databases

ProteinModelPortaliQ2KJI7.
SMRiQ2KJI7. Positions 306-549.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000030993.

Protein family/group databases

MEROPSiM41.016.

Proteomic databases

PaxDbiQ2KJI7.
PRIDEiQ2KJI7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000031029; ENSBTAP00000030993; ENSBTAG00000011250.
GeneIDi515757.
KEGGibta:515757.

Organism-specific databases

CTDi10939.

Phylogenomic databases

eggNOGiKOG0731. Eukaryota.
COG0465. LUCA.
GeneTreeiENSGT00840000129814.
HOGENOMiHOG000217277.
HOVERGENiHBG050184.
InParanoidiQ2KJI7.
KOiK08956.
OMAiFPTENTD.
OrthoDBiEOG7NW68F.
TreeFamiTF105004.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_01458. FtsH.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR005936. FtsH.
IPR027417. P-loop_NTPase.
IPR011546. Pept_M41_FtsH_extracell.
IPR000642. Peptidase_M41.
[Graphical view]
PfamiPF00004. AAA. 1 hit.
PF06480. FtsH_ext. 1 hit.
PF01434. Peptidase_M41. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01241. FtsH_fam. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.

Entry informationi

Entry nameiAFG32_BOVIN
AccessioniPrimary (citable) accession number: Q2KJI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: March 7, 2006
Last modified: June 8, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.