ID   CKS2_BOVIN              Reviewed;          79 AA.
AC   Q2KJI1;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   27-MAR-2024, entry version 106.
DE   RecName: Full=Cyclin-dependent kinases regulatory subunit 2;
DE            Short=CKS-2;
GN   Name=CKS2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds to the catalytic subunit of the cyclin dependent
CC       kinases and is essential for their biological function. {ECO:0000250}.
CC   -!- SUBUNIT: Forms a homohexamer that can probably bind six kinase
CC       subunits. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CKS family. {ECO:0000305}.
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DR   EMBL; BC105331; AAI05332.1; -; mRNA.
DR   RefSeq; NP_001106790.1; NM_001113319.2.
DR   AlphaFoldDB; Q2KJI1; -.
DR   SMR; Q2KJI1; -.
DR   STRING; 9913.ENSBTAP00000002522; -.
DR   PaxDb; 9913-ENSBTAP00000002522; -.
DR   Ensembl; ENSBTAT00000002522.4; ENSBTAP00000002522.3; ENSBTAG00000001938.4.
DR   GeneID; 767985; -.
DR   KEGG; bta:767985; -.
DR   CTD; 1164; -.
DR   VEuPathDB; HostDB:ENSBTAG00000001938; -.
DR   VGNC; VGNC:27388; CKS2.
DR   eggNOG; KOG3484; Eukaryota.
DR   GeneTree; ENSGT00950000182971; -.
DR   HOGENOM; CLU_140546_2_0_1; -.
DR   InParanoid; Q2KJI1; -.
DR   OMA; YERHAPE; -.
DR   OrthoDB; 204504at2759; -.
DR   TreeFam; TF101142; -.
DR   Proteomes; UP000009136; Chromosome 8.
DR   Bgee; ENSBTAG00000001938; Expressed in oocyte and 104 other cell types or tissues.
DR   GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IBA:GO_Central.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR   GO; GO:0061575; F:cyclin-dependent protein serine/threonine kinase activator activity; IBA:GO_Central.
DR   GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR   GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR   GO; GO:0043130; F:ubiquitin binding; IBA:GO_Central.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0048144; P:fibroblast proliferation; IEA:Ensembl.
DR   GO; GO:0007127; P:meiosis I; IEA:Ensembl.
DR   GO; GO:0044772; P:mitotic cell cycle phase transition; IEA:Ensembl.
DR   GO; GO:0007346; P:regulation of mitotic cell cycle; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   Gene3D; 3.30.170.10; Cyclin-dependent kinase, regulatory subunit; 1.
DR   InterPro; IPR000789; Cyclin-dep_kinase_reg-sub.
DR   InterPro; IPR036858; Cyclin-dep_kinase_reg-sub_sf.
DR   PANTHER; PTHR23415:SF49; CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT 2; 1.
DR   PANTHER; PTHR23415; CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7; 1.
DR   Pfam; PF01111; CKS; 1.
DR   PRINTS; PR00296; CYCLINKINASE.
DR   SMART; SM01084; CKS; 1.
DR   SUPFAM; SSF55637; Cell cycle regulatory proteins; 1.
DR   PROSITE; PS00944; CKS_1; 1.
DR   PROSITE; PS00945; CKS_2; 1.
PE   3: Inferred from homology;
KW   Acetylation; Cell cycle; Cell division; Reference proteome.
FT   CHAIN           1..79
FT                   /note="Cyclin-dependent kinases regulatory subunit 2"
FT                   /id="PRO_0000260447"
FT   MOD_RES         4
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:P33552"
SQ   SEQUENCE   79 AA;  9860 MW;  811B5927691EEC5C CRC64;
     MAHKQIYYSD KYFDEHYEYR HVMLPRELSK QVPKTHLMSE EEWRRLGVQQ SLGWVHYMIH
     EPEPHILLFR RPLPKDQQK
//